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Silver ion controlled-release antibacterial dressing, and preparation method and application thereof

A silver ion and silver nitrate technology, applied in chemical instruments and methods, bandages, inorganic chemistry, etc., can solve the problems of reducing antibacterial efficiency, concentration dependence of silver ion antibacterial effect, silver ion consumption, etc.

Active Publication Date: 2021-09-14
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, silver nitrate and silver sulfadiazine are often used as antibacterial agents to deliver silver ions, but the antibacterial effect of silver ions has a strong concentration dependence
In fact, the real physiological environment contains a large amount of Cl - , S 2- As well as proteins with a strong chelating effect on metal ions, the presence of these substances will lead to a large consumption of silver ions, thereby reducing its antibacterial efficiency

Method used

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  • Silver ion controlled-release antibacterial dressing, and preparation method and application thereof
  • Silver ion controlled-release antibacterial dressing, and preparation method and application thereof
  • Silver ion controlled-release antibacterial dressing, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Weigh 12g of polyvinyl alcohol 124 into a beaker, add 88mL of deionized water, and stir at 95°C for 5 hours. After lowering the solution temperature to 45°C, add 0.06g K 13 Na[AgP 5 W 30 o 110], continue stirring for 4 hours. Stirring and heating were stopped, and after standing for 16 hours, the dressing was spread on a glass plate and dried at 55° C. for 3 hours to obtain the antibacterial dressing.

Embodiment 2

[0060] Weigh 12g of polyvinyl alcohol 1799 into a beaker, add 28mL of deionized water, and stir at 95°C for 5 hours. After lowering the solution temperature to 50°C, add 0.12g K 13 Na[AgP 5 W 30 o 110 ], continue stirring for 4 hours. Stirring and heating were stopped, and after standing for 12 hours, the dressing was spread on a glass plate and dried at 50° C. for 3 hours to obtain the antibacterial dressing.

Embodiment 3

[0062] Weigh 12g of polyvinyl alcohol 1799 into a beaker, add 88mL of deionized water, and stir at 95°C for 5 hours. After lowering the solution temperature to 50°C, add 0.36g K 13 Na[AgP 5 W 30 o 110 ], continue stirring for 4 hours. Stirring and heating were stopped, and after standing for 12 hours, the dressing was spread on a glass plate and dried at 50° C. for 3 hours to obtain the antibacterial dressing.

[0063] The antiseptic dressing that embodiment 1~3 makes is almost the same as the scanning electron micrograph of the antiseptic dressing that does not contain polyacid comparative example 1 gained antiseptic dressing (as Figure 5 Shown), it can be seen that the surface and cross section of the prepared antibacterial dressing are very smooth and even. Granular spots appeared on the surface of the antibacterial wound dressing prepared in Comparative Example 4, and cracks appeared in the cross section, indicating that when the amount of polyacid added reached more...

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PUM

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Abstract

The invention discloses a silver ion controlled-release antibacterial dressing, and a preparation method and application thereof. The antibacterial dressing is prepared from polyvinyl alcohol, polyacid K13Na [AgP5W30O110] and water, wherein the polyacid K13Na [AgP5W30O110] accounts for 0.5-3% of the dry weight of PVA, and the mass ratio of the polyvinyl alcohol to the water is (1: 99)-(30: 70). The antibacterial dressing disclosed by the invention has good antibacterial performance and mechanical performance and has a good percolate absorption capacity, meanwhile, controlled release of silver ions is achieved, too fast consumption of silver ion concentration due to substances such as chloride ions and the like is avoided, long-acting bacteriostasis is realized, the preparation way is simple, and the manufacturing scale can be enlarged according to the proportion.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an antibacterial dressing with controlled release of silver ions, a preparation method and application thereof. Background technique [0002] The coverage of wounds by antibacterial wound dressings can avoid the adverse effects of mechanical factors and pollutants on wound healing to a certain extent. Wound dressings have some absorbency for exudate. The traditional dry gauze loaded with silver salt or nano-silver as an antibacterial wound dressing is very easy to adhere to the wound, and the subsequent cleaning is easy to cause secondary damage, which brings pain and risk to the patient. An ideal antibacterial wound dressing should not only have good antibacterial activity to effectively prevent wound infection, but also have strong drug loading capacity and sustained release performance. At the same time, it should also take into account the problem of...

Claims

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Application Information

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IPC IPC(8): A61L15/24A61L15/18A61L15/46C01B25/45C01G41/00
CPCA61L15/24A61L15/18A61L15/46C01G41/006C01B25/45A61L2300/104A61L2300/404A61L2300/602C08L29/04C01G41/00A61L15/00Y02A50/30
Inventor 陈坤殷盼超许哲玮
Owner SOUTH CHINA UNIV OF TECH
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