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Antibacterial fiber loaded with metal organic framework nano enzyme and glucose as well as preparation method and application of antibacterial fiber

A metal-organic framework and organic framework technology, applied in fiber type, fiber treatment, animal fiber, etc., can solve the problems of low cascade reaction activity, limit the practical application of infected wounds, etc., and achieve the effect of high-efficiency antibacterial performance

Active Publication Date: 2021-09-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Metal-organic framework nanozymes are usually used directly in powder form, but the glucose content contained in skin tissue is low, making the cascade reaction activity of the material system low, This greatly limits its practical application in infected wounds

Method used

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  • Antibacterial fiber loaded with metal organic framework nano enzyme and glucose as well as preparation method and application of antibacterial fiber
  • Antibacterial fiber loaded with metal organic framework nano enzyme and glucose as well as preparation method and application of antibacterial fiber
  • Antibacterial fiber loaded with metal organic framework nano enzyme and glucose as well as preparation method and application of antibacterial fiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation of embodiment 1 polycaprolactone electrospun fiber membrane

[0050] Weigh 1.2g, 1.5g, 1.8g, and 2.1g of PCL (average molecular weight: 80,000) pellets and add them into 15mL of 2,2,2-trifluoroethanol, and stir at room temperature for 12 hours to obtain 8%, 10%, 12%, and 14 %PCL transparent spinning solution.

[0051] Since the solution concentration, electrospinning rate, voltage, receiving distance and humidity temperature will all affect the morphology of the fiber, it is necessary to prepare uniform and continuous fibers under the condition that the electrospinning solution is stable and the electrospinning process is carried out smoothly. One of the key issues of silk. After adjusting the external factors affecting spinning and other factors, the optimal spinning conditions were obtained: the spinning concentration was 14%, the voltage was 10kV, the receiving distance was 15cm, and the advancing rate was 2.0mL / h. Use a 10mL disposable syringe to e...

Embodiment 2

[0053] Example 2 Preparation of electrospun fiber membrane with polycaprolactone / gelatin / glucose sandwich multilayer structure

[0054] Weigh 1.0g of glucose and dissolve it in 1mL of deionized water at high temperature, continue to add 9mL of glacial acetic acid, stir well; add 5mL of 2,2,2-trifluoroethanol, mix well; add 1.5g of gelatin (glue strength is about 250gBloom), Stirring was continued for 2 hours to obtain a uniform 10%GE / 6.7%D-glu spinning solution. In addition, 2.1 g of PCL (average molecular weight: 80,000) was dissolved in 15 mL of 2,2,2-trifluoroethanol, and stirred evenly at room temperature overnight to obtain a uniform 14% PCL spinning solution.

[0055] Firstly, 1mL of GE / D-glu spinning solution was drawn out with a 10mL disposable syringe and placed on a syringe pump. Electrospinning was carried out by using a 21-gauge flat needle and adjusting the distance and voltage between the needle and the receiving plate. Spinning conditions: the voltage is 20kV, ...

Embodiment 3

[0057] The preparation of embodiment 3 polycaprolactone / gelatin / glucose blended fiber membrane (PCL / GE / D-glu)

[0058] Weigh 1.0g of glucose and dissolve it in 1mL of deionized water at high temperature; continue to add 9mL of glacial acetic acid and stir well; add 5mL of 2,2,2-trifluoroethanol and mix well; finally add 2.1g of polycaprolactone and 1.5g of gelatin (glue strength is about 250gBloom), continue to stir for 2h, obtain uniform yellow transparent solution, as Figure 4 shown. The solvent ratio (water / glacial acetic acid / 2,2,2-trifluoroethanol) in the final spinning solution is 1:9:5, and the solute fraction (polycaprolactone / gelatin / glucose) is 14%PCL / 10%GE / 6.7% D-glu.

[0059] Use a 10mL disposable syringe to extract 4mL of spinning solution and put it on a syringe pump. Use a No. 21 flat needle and adjust the distance and voltage between the needle and the receiving plate to carry out electrospinning. Spinning conditions: the voltage is 18kV, the receiving dis...

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Abstract

The invention discloses an antibacterial fiber loaded with metal organic framework nano enzyme and glucose as well as a preparation method and application of the antibacterial fiber. The method comprises the following steps that a spinning solution is prepared from glucose, a hydrophilic high-molecular compound and a hydrophobic high-molecular compound, and spinning is conducted to obtain a glucose-loaded fibrous membrane; glucose oxidase is modified on the surfaces of metal organic framework nano particles with catalytic activity similar to that of peroxidase through amido bond reaction to obtain glucose oxidase modified metal organic framework nano enzyme, then the glucose oxidase modified metal organic framework nano enzyme is deposited on the surface of a glucose-loaded fiber membrane, and air drying is performed to obtain the antibacterial fiber. The method is simple to operate and low in cost. The obtained antibacterial fiber, the glucose and the metal organic framework nano-enzyme have a cascade antibacterial characteristic, an in-situ antibacterial effect can be achieved without external supply, and the antibacterial fiber has efficient antibacterial performance on various bacteria, can be applied to treatment and repair of infected wounds and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of antibacterial medical materials, and in particular relates to an antibacterial fiber loaded with metal organic framework nano-enzymes and glucose, a preparation method and application thereof. Background technique [0002] Nanozyme is a kind of nanomaterial that can exhibit properties similar to natural enzymes (such as peroxidase, catalase, oxidase, etc.), and has the advantages of low preparation cost, easy synthesis and stable activity compared with natural enzymes. Metal-organic framework (MOF) nanozymes have attracted extensive attention due to their high porosity and specific surface area. In particular, metal-organic framework nanozymes with peroxidase (POD)-like characteristics can react with H at pH = 3-4 2 o 2 Hydroxyl radicals (·OH) are generated through the Fenton reaction, and the use of ·OH directly destroys the bacterial membrane structure to exert an effective antibacterial effect. Currently, a m...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/20A61L15/46A61L15/42A61L15/26D06M16/00D01F8/14D01F8/02D01F1/10D04H1/4382D04H1/728D01D5/00
CPCA61L15/32A61L15/20A61L15/46A61L15/42A61L15/26D06M16/003D01F8/14D01F8/02D01F1/10D04H1/43825D04H1/728D01D5/003D01D5/0092D01D5/0061A61L2300/404A61L2300/254A61L2400/12A61L2300/232A61L2300/602A61L2300/45D06M2101/32D06M2101/10C08L89/00C08L67/04Y02A50/30
Inventor 吴刚何王美
Owner SOUTH CHINA UNIV OF TECH
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