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A kind of desonide cream and preparation method thereof

A technology of desonide and cream, applied in the field of medicine, can solve problems such as poor stability

Active Publication Date: 2022-07-05
FRONT PHARM PLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the defects of the prior art, the invention provides a kind of desonide emulsifiable paste and preparation method thereof, which overcomes the problem of poor stability of the desonide emulsifiable paste preparation, and obtains a long-term storage which can keep the paste uniform and stable, Desonide cream that can keep the paste properties and active ingredients stable under different environments (including temperature, humidity, and light), and is convenient for transportation and storage

Method used

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  • A kind of desonide cream and preparation method thereof
  • A kind of desonide cream and preparation method thereof
  • A kind of desonide cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024]

[0025]

[0026] Preparation:

[0027] 1) Preparation of aqueous phase: heat purified water to 70°C to 75°C, add buffered p-phosphate-sodium phosphate buffered pair (pH=5), dextrin, nonylphenol polyoxyethylene ether and methylparaben, and stir and mix. Evenly, keep warm and reserve;

[0028] 2) Preparation of oil phase: the oily base, including light liquid paraffin, cetostearyl alcohol, white vaseline, and beeswax, is heated to melting to obtain an oil phase material, which is kept at 70°C to 75°C for later use;

[0029] 3) Preparation of the main drug dispersion: desonide is dispersed in glycerol to obtain the main drug dispersion suspension;

[0030] 4) total mixing: mixing the oil phase material and the water phase material, adding the main drug dispersion suspension;

[0031] 5) Cooling: mix evenly and cool to room temperature to obtain desonide cream.

Embodiment 2

[0033] composition Dosage Denide 55.0g Citric Acid - Sodium Citrate 110.0g castor oil polyoxyethylene ether 1.1kg dextrin 22.0g methylparaben 110.0g glycerin 4.40kg cetostearyl alcohol 13.2kg White Vaseline 16.5kg purified water 74.5kg total 110kg

[0034] Preparation:

[0035] 1) Preparation of aqueous phase: heated purified water to 70°C to 75°C, add buffered p-citric acid-sodium citrate buffered pair (pH=5.5), dextrin, castor oil polyoxyethylene ether and paraben Stir and mix the ester, keep warm for later use;

[0036] 2) Preparation of oil phase: the oily base, including cetostearyl alcohol and white petrolatum, is heated to melting to obtain oil phase material, which is kept at 70°C to 75°C for later use;

[0037] 3) Preparation of the main drug dispersion: desonide is dispersed in glycerol to obtain the main drug dispersion suspension;

[0038] 4) total mixing: mixing the oil phase materi...

Embodiment 3

[0041] composition Dosage Denide 55.0g Citric acid-disodium hydrogen phosphate 220.0g oleyl alcohol polyoxyethylene ether 1.1kg Octylphenol polyoxyethylene ether 1.1kg dextrin 11.0g methylparaben 220.0g glycerin 6.60kg Light liquid paraffin 2.2kg cetostearyl alcohol 16.5kg White Vaseline 13.2kg beeswax 6.6kg purified water 62.2kg total 110kg

[0042] Preparation:

[0043] 1) Preparation of water phase: heat purified water to 70°C to 75°C, add buffered citric acid-disodium hydrogen phosphate buffered pair (pH=4.5), dextrin, oleyl alcohol polyoxyethylene ether, octylphenol Polyoxyethylene ether and methylparaben are stirred and mixed, and kept for later use;

[0044] 2) Preparation of oil phase: the oily base, comprising light liquid paraffin, cetostearyl alcohol, white vaseline, and beeswax, is heated to melting to obtain an oil phase material, which is kept at 70°C to 75°C for...

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Abstract

The invention provides a desonide cream and a preparation method thereof, comprising as active ingredients desonide, a polyoxyethylene ether emulsifier, a buffer pair, dextrin, glycerin, an antibacterial agent and an oily base; the buffer pair The pH range formed when dissolved in water is 4.5-5.5. The desonide cream has no obvious change in properties after high temperature and high humidity, low temperature, freezing and thawing and illumination, and the maximum single impurities and total impurities have no obvious increase, and can adapt to various environmental conditions encountered in storage and transportation. Meanwhile, the desonide cream disclosed by the invention has a simple preparation process and is easy to industrialize production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a desonide cream and a preparation method thereof. Background technique [0002] Topical glucocorticoids have the advantages of high efficacy, quick effect, good compliance, and easy acceptance by patients, and are one of the drugs commonly prescribed by dermatologists. Desonide is a weak hormone with anti-inflammatory, anti-allergic, antipruritic and anti-exudation effects, can reduce the response of tissue inflammation, eliminate congestion and edema caused by local inflammation, and has good safety and effectiveness. [0003] Currently, the approved dosage forms of desonide preparations are external preparations, especially cream dosage forms, which are widely used. Cream preparations are usually stored in a closed, cool place. The stability of cream formulations is also poorer than other solid formulations. Therefore, the cream preparation is prone to change i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/58A61K47/10A61P7/10A61P17/04A61P29/00A61P37/08
CPCA61K31/58A61K9/06A61K47/10A61K9/0014A61P29/00A61P37/08A61P17/04A61P7/10Y02A50/30
Inventor 陈俊宁杰刘营营
Owner FRONT PHARM PLC
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