Surface-modified porous polyether-ether-ketone artificial bone and preparation method thereof

A polyetheretherketone and surface modification technology is applied in the field of surface-modified porous polyetheretherketone artificial bone and its preparation, which can solve the problems of low matching degree between artificial bone and human body and unsatisfactory implantation effect. To achieve the effect of improving adhesion and promoting division and growth

Active Publication Date: 2021-09-24
GUANGXI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In view of this, the present invention discloses a surface-modified porous polyetheretherketone artificial bone and its preparation me

Method used

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Examples

Experimental program
Comparison scheme
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Example Embodiment

[0045] Example 1

[0046] Minimum period of three surface equation is: (Where x is in the range (-10,10), y is in the range (-10,10), Z is in the range of (-10,10)) analyzing, for three cycles electrode design met discrete little value surface. Obtaining discrete points using inverse modeling skeleton model artificial leg, the artificial leg skeleton model built good melt input 3D deposition printing apparatus, a thermal fuse select PEEK, PEEK prepared using fused deposition techniques artificial leg bone;

[0047] The mass ratio of 50:50 DMSO and sodium borohydride is introduced into the reaction flask, and dissolved with stirring at 120 deg.] C, to give a concentration of 50% by mass sodium boron hydride / dimethyl sulfoxide solution reaction. The artificial leg bones printed PEEK artificial bones, immersed in sodium boron hydride / dimethyl sulfoxide in the reaction solution was taken out after a reaction 3h, washed with methanol, deionized water, dilute hydrochloric acid, e...

Example Embodiment

[0049] Example 2

[0050] Minimum period of three surface equation (Where x is in the range (-10,10), y is in the range (-10,10), Z is in the range of (-10,10)) analyzing, for three cycles electrode design met discrete little value surface. Obtaining discrete points using inverse modeling skeleton model artificial leg, the artificial leg skeleton model built good input laser powder sintering 3D printing apparatus, select PEEK powder, a powder prepared using laser sintering PEEK artificial leg bone; mass ratio of 60: 40 of dimethyl sulfoxide, and the introduction of sodium borohydride the reaction flask, and dissolved with stirring at 140 deg.] C, to give a concentration of 40% by mass sodium boron hydride / dimethyl sulfoxide solution of the reaction. After the artificial leg bones printed PEEK artificial bones, immersed in sodium boron hydride / dimethylsulfoxide taken for 5h the reaction solution, washed with methanol, deionized water, dilute hydrochloric acid, ethanol and de...

Example Embodiment

[0051] Example 3

[0052] Minimum period of three surface equation (Where x is in the range (-10,10), y is in the range (-10,10), Z is in the range of (-10,10)) analyzing, for three cycles electrode design met discrete little value surface. Obtaining discrete points using inverse modeling toe artificial bone model, the bone model built good artificial toe 3D input fused deposition printing apparatus, a thermal fuse select PEEK, PEEK prepared using fused deposition techniques artificial bone toes; mass ratio of 95: dimethyl sulfoxide and sodium borohydride 5 introduced into the reaction flask, and dissolved with stirring at 110 deg.] C, to give a concentration of 5% by mass sodium boron hydride / dimethyl sulfoxide solution reaction. The printed PEEK artificial toe bones, immersed in sodium borohydride / dimethylsulfoxide 6h the reaction solution after the reaction taken, successively washed with methanol, deionized water, dilute hydrochloric acid, ethanol and deionized water ri...

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Abstract

The invention discloses a preparation method of a surface-modified porous polyether-ether-ketone artificial bone, which comprises the following steps: establishing discrete points of a three-dimensional topological structure by adopting a three-period minimal curved surface method, carrying out reverse modeling by utilizing the discrete points to generate an artificial bone model, and preparing the porous polyether-ether-ketone artificial bone by adopting an additive manufacturing method according to the artificial bone model; converting carbonyl in a polyether-ether-ketone molecular structure on the surface of the artificial bone into hydroxyl by utilizing a chemical reaction, and respectively reacting high-activity isocyanate serving as an intermediate with the hydroxyl on the surface of polyether-ether-ketone and an amino-containing compound to obtain the surface-modified polyether-ether-ketone artificial bone. The surface-modified porous polyether-ether-ketone artificial bone prepared by the technical scheme of the invention not only has a gradient continuous change pore structure, but also can promote division and growth of cells by introducing enough bioactive substances on the surface, and improves the adhesion ability of cells on the surface of the bone.

Description

technical field [0001] The disclosure of the invention relates to the technical field of porous artificial bone manufacture, in particular to a surface-modified porous polyetheretherketone artificial bone and a preparation method thereof. Background technique [0002] Artificial bone refers to an artificial biomaterial that can replace human bone or repair bone tissue defects, and can also be used as an implantable scaffold structure material. Therefore, artificial bone must meet: (1) have good biocompatibility; (2) ) has suitable mechanical properties; (3) has suitable microporous structure, so that new bone tissue can grow inward; (4) is easy to process into required size and shape. Good biocompatibility can avoid the human body's rejection of artificial bone, so that the scaffold structure can be integrated into the human environment; a good pore structure is conducive to the growth of osteoblasts into the scaffold structure and the vascularization of the scaffold materia...

Claims

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Application Information

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IPC IPC(8): C08J9/40A61L27/56A61L27/54A61L27/50A61L27/18B29C64/386B33Y50/00C08L61/16
CPCC08J9/40A61L27/18A61L27/50A61L27/54A61L27/56B29C64/386B33Y50/00A61L2430/02A61L2400/18A61L2300/414A61L2300/252C08J2361/16C08L61/16
Inventor 陆春郑立高明覃再嫩齐文高智华
Owner GUANGXI UNIV FOR NATITIES
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