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Surface-modified porous polyether-ether-ketone artificial bone and preparation method thereof

A polyetheretherketone and surface modification technology is applied in the field of surface-modified porous polyetheretherketone artificial bone and its preparation, which can solve the problems of low matching degree between artificial bone and human body and unsatisfactory implantation effect. To achieve the effect of improving adhesion and promoting division and growth

Active Publication Date: 2021-09-24
GUANGXI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In view of this, the present invention discloses a surface-modified porous polyetheretherketone artificial bone and its preparation method to solve the artificial The degree of matching between the bone and the human body is not high, and the implantation effect is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The three-period minimum surface equation is: (The value range of x is (-10,10), the value range of y is (-10,10), and the value range of z is (-10,10). Discrete points for small-valued surfaces. Using discrete point reverse modeling to obtain the artificial calf bone model, input the built artificial calf bone model into the fused deposition 3D printing equipment, select PEEK thermal fuse, and use the fused deposition technology to prepare the PEEK artificial calf bone;

[0047] Introduce dimethyl sulfoxide and sodium borohydride at a mass ratio of 50:50 into the reaction flask, stir and dissolve at 120° C. to obtain a sodium borohydride / dimethyl sulfoxide reaction solution with a mass concentration of 50%. The printed PEEK artificial calf bone artificial bone was immersed in the sodium borohydride / dimethyl sulfoxide reaction solution for 3 hours and then taken out, followed by washing with methanol, deionized water, dilute hydrochloric acid, deionized water and ab...

Embodiment 2

[0050] For three-period minimum surface equations (The value range of x is (-10,10), the value range of y is (-10,10), and the value range of z is (-10,10). Discrete points for small-valued surfaces. Using discrete point reverse modeling to obtain the artificial calf bone model, input the built artificial calf bone model into the laser powder sintering 3D printing equipment, select PEEK powder, and use the laser powder sintering process to prepare the PEEK artificial calf bone; the mass ratio is 60: 40 is introducing dimethyl sulfoxide and sodium borohydride into the reaction flask, stirring and dissolving at 140° C. to obtain a sodium borohydride / dimethyl sulfoxide reaction solution with a mass concentration of 40%. The printed PEEK artificial calf bone artificial bone was immersed in the sodium borohydride / dimethyl sulfoxide reaction solution for 5 hours and then taken out, followed by washing with methanol, deionized water, dilute hydrochloric acid, deionized water and ...

Embodiment 3

[0052] For three-period minimum surface equations (The value range of x is (-10,10), the value range of y is (-10,10), and the value range of z is (-10,10). Discrete points for small-valued surfaces. Use discrete point reverse modeling to obtain the artificial toe bone model, input the built artificial toe bone model into the fused deposition 3D printing device, select PEEK thermal fuse, and use the fused deposition technology to prepare the PEEK artificial toe bone; the mass ratio is 95: 5 dimethyl sulfoxide and sodium borohydride were introduced into the reaction flask, stirred and dissolved at 110°C to obtain a sodium borohydride / dimethyl sulfoxide reaction solution with a mass concentration of 5%. The printed PEEK artificial toe bone was immersed in the sodium borohydride / dimethyl sulfoxide reaction solution for 6 hours and then taken out, followed by washing with methanol, deionized water, dilute hydrochloric acid, deionized water and absolute ethanol. After rinsing,...

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Abstract

The invention discloses a preparation method of a surface-modified porous polyether-ether-ketone artificial bone, which comprises the following steps: establishing discrete points of a three-dimensional topological structure by adopting a three-period minimal curved surface method, carrying out reverse modeling by utilizing the discrete points to generate an artificial bone model, and preparing the porous polyether-ether-ketone artificial bone by adopting an additive manufacturing method according to the artificial bone model; converting carbonyl in a polyether-ether-ketone molecular structure on the surface of the artificial bone into hydroxyl by utilizing a chemical reaction, and respectively reacting high-activity isocyanate serving as an intermediate with the hydroxyl on the surface of polyether-ether-ketone and an amino-containing compound to obtain the surface-modified polyether-ether-ketone artificial bone. The surface-modified porous polyether-ether-ketone artificial bone prepared by the technical scheme of the invention not only has a gradient continuous change pore structure, but also can promote division and growth of cells by introducing enough bioactive substances on the surface, and improves the adhesion ability of cells on the surface of the bone.

Description

technical field [0001] The disclosure of the invention relates to the technical field of porous artificial bone manufacture, in particular to a surface-modified porous polyetheretherketone artificial bone and a preparation method thereof. Background technique [0002] Artificial bone refers to an artificial biomaterial that can replace human bone or repair bone tissue defects, and can also be used as an implantable scaffold structure material. Therefore, artificial bone must meet: (1) have good biocompatibility; (2) ) has suitable mechanical properties; (3) has suitable microporous structure, so that new bone tissue can grow inward; (4) is easy to process into required size and shape. Good biocompatibility can avoid the human body's rejection of artificial bone, so that the scaffold structure can be integrated into the human environment; a good pore structure is conducive to the growth of osteoblasts into the scaffold structure and the vascularization of the scaffold materia...

Claims

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Application Information

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IPC IPC(8): C08J9/40A61L27/56A61L27/54A61L27/50A61L27/18B29C64/386B33Y50/00C08L61/16
CPCC08J9/40A61L27/18A61L27/50A61L27/54A61L27/56B29C64/386B33Y50/00A61L2430/02A61L2400/18A61L2300/414A61L2300/252C08J2361/16C08L61/16
Inventor 陆春郑立高明覃再嫩齐文高智华
Owner GUANGXI UNIV FOR NATITIES
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