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Application of diacerein and spleen--tonifying and dampness-removing medicines in preparation of medicines for treating osteoarthritis

A technology of invigorating the spleen and removing dampness and diacerein, which is applied in the field of medicine, can solve the problems of poor patient adaptability, high cost, and various medicinal flavors, and achieve the effect of reducing irritation and incidence

Inactive Publication Date: 2021-10-01
SUZHOU CHUNGHWA CHEM & PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional Chinese medicine compound usually requires a variety of different medicinal materials to be compatible with each other in order to relieve diarrhea, which has the problems of various medicinal flavors, low therapeutic effect, high cost, and poor patient adaptability.

Method used

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  • Application of diacerein and spleen--tonifying and dampness-removing medicines in preparation of medicines for treating osteoarthritis
  • Application of diacerein and spleen--tonifying and dampness-removing medicines in preparation of medicines for treating osteoarthritis

Examples

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Embodiment 1

[0030] This embodiment provides a pharmaceutical composition, including 50g of diacerein and 60g of Poria cocos extract.

[0031] This embodiment also provides a capsule, which includes the above pharmaceutical composition, and also includes 173 g of lactose (60 mesh), 15 g of croscarmellose sodium, and 2 g of magnesium stearate.

[0032] The preparation method of the above-mentioned capsules comprises the steps of: putting 60 meshes of lactose, poria cocos extract, diacerein and cross-linked carmellose sodium into a V-type mixer for premixing for 10 minutes, and then adding Magnesium stearate was mixed for 3 minutes, filled with a capsule filling machine by the specification of 0.3g / grain with No. 1 hard capsules, packing: check and remove defective capsules, and polish. Qualified capsules are packed in blisters of aluminum-plastic composite film.

Embodiment 2

[0034] This embodiment provides a pharmaceutical composition, including 50 g of diacerein and 60 g of poria cocos powder.

[0035] This embodiment also provides a capsule, which includes the above pharmaceutical composition, and also includes 173 g of lactose (60 mesh), 15 g of croscarmellose sodium, and 2 g of magnesium stearate.

[0036] The preparation method of the above-mentioned capsules comprises the steps of: putting 60 meshes of lactose, poria cocos powder, diacerein, and cross-linked carmellose sodium into a V-shaped mixer for premixing for 10 minutes, and then adding hard Magnesium fatty acid was mixed for 3 minutes, filled with No. 1 hard capsule by the specification of 0.3g / capsule with a capsule filling machine, packing: check and remove defective capsules, and polish. Qualified capsules are packed in blisters of aluminum-plastic composite film.

Embodiment 3

[0038] This embodiment provides a pharmaceutical composition, including 50 g of diacerein and 90 g of white lentil extract.

[0039] This embodiment also provides a capsule, which includes the above pharmaceutical composition, and also includes 143 g of lactose (60 mesh), 15 g of croscarmellose sodium, and 2 g of magnesium stearate.

[0040] The preparation method of the above-mentioned capsules comprises the steps of: putting 60 meshes of lactose, white lentil extract, diacerein, and cross-linked carmellose sodium into a V-type mixer for premixing for 10 minutes, and then Add magnesium stearate and mix for 3 minutes, fill with capsule filling machine according to the specification of 0.3g / granule with No. 1 hard capsule, pack: inspect and remove bad capsules, polish. Qualified capsules are packed in blisters of aluminum-plastic composite film.

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Abstract

The invention provides application of diacerein and spleen-tonifying and dampness-removing medicines in preparation of medicines for treating osteoarthritis. Researches find that the spleen-tonifying and dampness-removing medicines such as poria cocos, white hyacinth beans, coix seeds, poria cocos extract, white hyacinth bean extract and coix seed extract contain a large amount of polysaccharides which can be combined with rhein generated by metabolism of diacerein in intestinal tracts, so as to prevent the conversion of the rhein to the anthrone rhein. The irritation of the anthrone rhein to intestinal tracts is obviously reduced, the incidence rate of diarrhea is reduced, and the substances can also play a synergistic effect with the diacerein capsule, so that the effect of treating osteoarthritis is obviously improved.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of diacerein and spleen-invigorating and damp-reducing medicines in the preparation of medicines for treating osteoarthritis. Background technique [0002] Diarrhea is a common adverse effect associated with diacerein treatment. It is a type of drug-induced diarrhea that may occur without warning and escalate to severe diarrhea within hours. Even mild to moderate diarrhea can be life-threatening when complicated by vomiting, dehydration, or neutropenia. [0003] Although broad-spectrum antibiotics have been used to eliminate gut bacteria from the GI tract prior to chemotherapy treatment to reduce reactivation, this approach has several disadvantages. On the one hand, gut bacteria play a crucial role in the metabolism of carbohydrates, the production of vitamins, and the processing of bile acids, sterols, and xenobiotics. However, these broad-spectrum antibioti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/076A61K36/48A61K36/8994A61K36/284A61K31/222A61P1/12A61P19/02
CPCA61K36/076A61K36/48A61K36/8994A61K36/284A61K31/222A61P1/12A61P19/02A61K2300/00
Inventor 王蓉
Owner SUZHOU CHUNGHWA CHEM & PHARMA IND