Preparation method of beta-nicotinamide mononucleotide

A single nucleotide, nicotinamide technology, applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of long production process, high organic impurity content, and high energy consumption, and achieves safety and reliability. The effect of improving environmental protection, reducing the content of organic impurities, and shortening the reaction process

Pending Publication Date: 2021-10-19
SHANGHAI CHANGFA NEW MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem solved by the present invention is to solve the long production process, long reaction time, low efficiency, many side reactions, low product yield and high content of organic impurities in the method for preparing β-nicotinamide mononucleotide in the prior art. , high energy consumption, and the defects of large equipment footprint, providing a preparation method for β-nicotinamide mononucleotide

Method used

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  • Preparation method of beta-nicotinamide mononucleotide
  • Preparation method of beta-nicotinamide mononucleotide
  • Preparation method of beta-nicotinamide mononucleotide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] in such as figure 1 Carry out following reaction or separation step in the reaction system shown:

[0071] S1: Condensation reaction

[0072] Mix 38 parts of nicotinamide, 48 parts of D-ribose and 400 parts of tetrahydrofuran in the feeding tank, and add 70 parts of triethylsilicon trifluoromethanesulfonate into another feeding tank, and the liquids in the two feeding tanks are respectively from The first feed port 12 and the second feed port 11 are driven into the first microchannel reactor 1, and the temperature of the first nine microchannel modules of the first microchannel reactor 1 is set to be 80° C., and the tenth microchannel The module temperature is 75°C, the total residence time is set to 2 minutes, and the material A is obtained through condensation reaction.

[0073] S2: thin film evaporator evaporation

[0074] Material A and triethyl phosphate are mixed in the mixer 2 at a mass ratio of 5:3, and then poured into the thin film evaporator 3 continuously...

Embodiment 2

[0080] S1: Condensation reaction

[0081] Mix 38 parts of nicotinamide, 48 parts of D-ribose and 500 parts of tetrahydrofuran in the feeding tank, and add 70 parts of triethylsilicon trifluoromethanesulfonate into another feeding tank, and the liquids in the two feeding tanks are respectively from The first feed port 12 and the second feed port 11 are driven into the first microchannel reactor 1, and the temperature of the first nine microchannel modules of the first microchannel reactor 1 is set to be 75° C., and the tenth microchannel The module temperature is 70°C, the total residence time is set to 4 minutes, and the material A is obtained through condensation reaction.

[0082] S2: thin film evaporator evaporation

[0083] Material A and triethyl phosphate were mixed in the mixer 2 at a mass ratio of 5:4 and then poured into the thin-film evaporator 3 continuously. Other steps were the same as S2 in Example 1.

[0084] Both S3 and S4 are the same as in Example 1.

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Abstract

The invention discloses a preparation method of beta-nicotinamide mononucleotide. The preparation method comprises the following steps: S1, in the presence of a catalyst and a first solvent, carrying out condensation reaction on nicotinamide and D-ribose in a first microchannel reactor to obtain a material A containing beta-nicotinamide-D-ribose; wherein the temperature of the condensation reaction is 51-90 DEG C, and the retention time of the condensation reaction is 0.5-10 minutes; S2, removing the first solvent from a mixture of the material A and a second solvent to obtain a material B; S3, carrying out phosphorylation reaction on the material B and a phosphorylation auxiliary agent to obtain a material C containing beta-nicotinamide mononucleotide. The preparation method disclosed by the invention can effectively shorten the reaction time, improve the production efficiency, reduce side reactions, improve the product yield, reduce the content of organic impurities in the product and reduce the occupied area of equipment; meanwhile, the steps of deacetylation and ammonolysis are reduced, and the reaction process is shortened.

Description

technical field [0001] The invention specifically relates to a preparation method of β-nicotinamide mononucleotide. Background technique [0002] β-nicotinamide mononucleotide (NMN) is a naturally occurring biologically active nucleotide, which can be synthesized in the human body and can also be ingested from daily vegetables and meat. It is closely related to human immunity and metabolism. The function of β-nicotinamide mononucleotide in the body is mainly reflected by nicotinamide adenine dinucleotide, which is widely distributed in all cells and participates in thousands of biocatalytic reactions. In recent years, the anti-aging effect of nicotinamide adenine dinucleotide has attracted widespread attention in the scientific community. A large number of animal experiments have shown that after increasing the content of nicotinamide adenine dinucleotide, the aging organs can be restored to their youthful state, while supplementing β-nicotinamide mononucleotide is the best...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/00C07H19/048
CPCC07H1/00C07H19/048
Inventor 施晓旦金霞朝郑小群
Owner SHANGHAI CHANGFA NEW MATERIAL CO LTD
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