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A kind of preparation method and use of cinnamic acid-modified hydroxypropyl chitosan derivative

A technology of hydroxypropyl chitosan and cinnamic acid, which is applied in the fields of botanical equipment and methods, chemicals for biological control, applications, etc., can solve the problems of not very common application, limited application value, low antibacterial activity, etc. , to achieve the effect of wide dissolution range, high substitution degree and yield, and improved water solubility

Active Publication Date: 2022-07-29
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cinnamic acid is insoluble in water, which greatly limits its application and potential value in the food industry
[0005] However, because chitosan is a natural macromolecular product, when used as a food antiseptic and antibacterial agent, compared with traditional chemical preservatives, it still has disadvantages such as low antibacterial activity and poor water solubility, so it is currently used in the food industry. not very common

Method used

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  • A kind of preparation method and use of cinnamic acid-modified hydroxypropyl chitosan derivative
  • A kind of preparation method and use of cinnamic acid-modified hydroxypropyl chitosan derivative
  • A kind of preparation method and use of cinnamic acid-modified hydroxypropyl chitosan derivative

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Effect test

Embodiment 1

[0041] The preparation method of cinnamic acid-modified hydroxypropyl chitosan derivative comprises the following steps:

[0042] 1. Preparation of Hydroxypropyl Chitosan

[0043] The chitosan with a molecular weight of 100kDa and a degree of deacetylation of 80% was selected.

[0044]Add 15 mL of 50% sodium hydroxide aqueous solution to 5 g of chitosan, stir at room temperature for 3 hours to make it evenly mixed, and place it in a -20 °C refrigerator for 24 hours to fully alkalize and expand the chitosan; thaw and transfer the mixture Put it into a three-necked flask containing 50 mL of isopropanol, stir vigorously for 30 min at room temperature, add 1 mL of 25% tetramethylammonium hydroxide and 50 mL of propylene oxide under stirring, continue to stir at room temperature for 1 hour, and reflux at 45°C for 6 hours, the reaction is complete Then, it was cooled to room temperature, purified by ultrapure water dialysis for 72h (the cut-off molecular weight of the dialysis bag ...

Embodiment 2

[0055] The preparation method of cinnamic acid-modified hydroxypropyl chitosan derivative comprises the following steps:

[0056] 1. Preparation of Hydroxypropyl Chitosan

[0057] The chitosan with a molecular weight of 100kDa and a degree of deacetylation of 80% was selected.

[0058] Add 15 mL of 50% sodium hydroxide aqueous solution to 5 g of chitosan, stir at room temperature for 3 hours to make it evenly mixed, and place it in a -20 °C refrigerator for 24 hours to fully alkalize and expand the chitosan; thaw and transfer the mixture Put it into a three-necked flask containing 50 mL of isopropanol, stir vigorously for 30 min at room temperature, add 1 mL of 25% tetramethylammonium hydroxide and 50 mL of propylene oxide under stirring, continue to stir at room temperature for 1 hour, and reflux at 45°C for 6 hours, the reaction is complete Then, it was cooled to room temperature, purified by ultrapure water dialysis for 72h (the cut-off molecular weight of the dialysis bag...

Embodiment 3

[0063] The preparation method of cinnamic acid-modified hydroxypropyl chitosan derivative comprises the following steps:

[0064] 1. Preparation of Hydroxypropyl Chitosan

[0065] The chitosan with a molecular weight of 100kDa and a degree of deacetylation of 80% was selected.

[0066] Add 15 mL of 50% sodium hydroxide aqueous solution to 5 g of chitosan, stir at room temperature for 3 hours to make it evenly mixed, and place it in a -20 °C refrigerator for 24 hours to fully alkalize and expand the chitosan; thaw and transfer the mixture Put it into a three-necked flask containing 50 mL of isopropanol, stir vigorously for 30 min at room temperature, add 1 mL of 25% tetramethylammonium hydroxide and 50 mL of propylene oxide under stirring, continue to stir at room temperature for 1 hour, and reflux at 45°C for 6 hours, the reaction is complete Then, it was cooled to room temperature, purified by ultrapure water dialysis for 72h (the cut-off molecular weight of the dialysis bag...

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Abstract

The invention discloses a preparation method and application of a cinnamic acid-modified hydroxypropyl chitosan derivative. The substitution degree of the cinnamic acid is 0.23-0.93. The preparation method of the cinnamic acid-modified hydroxypropyl chitosan derivative includes the following steps: , water-soluble chemical modification of chitosan, introduction of hydroxypropyl hydrophilic groups to obtain water-soluble hydroxypropyl chitosan, and then introduction of cinnamic acid into hydroxypropyl chitosan, cinnamic acid obtained after purification Modified hydroxypropyl chitosan derivatives. The preparation method of the invention is simple, the cost is low, the purification method is simple and the property is stable, and the obtained cinnamic acid-modified hydroxypropyl chitosan derivative has good water solubility and antibacterial activity, and has good resistance to Staphylococcus aureus and Escherichia coli. It has good application prospects in the fields of medicine, food, cosmetics and agriculture.

Description

technical field [0001] The invention belongs to the technical field of food additives, and in particular relates to a preparation method and application of a cinnamic acid-modified hydroxypropyl chitosan derivative. Background technique [0002] With the development of the food industry, in order to prolong the shelf life of food and inhibit the contamination of microorganisms, the traditional physical preservative methods no longer meet the demand. The method of adding preservatives has been quickly applied because of its simplicity, durability and lower cost. Due to the potential cumulative toxicity of chemical preservatives, misuse or overdose can pose food safety concerns. With the improvement of people's living standards and the enhancement of safety awareness, some safe, non-toxic and green natural preservatives are more favored by people. [0003] Chitosan is a natural preservative extracted from animal-related substances. It is widely distributed, easy to obtain, in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08A01N43/16A01P1/00A61P31/04
CPCC08B37/003A01N43/16A61P31/04Y02A50/30
Inventor 乐琳王敏赵玲玉彭池方王周平
Owner JIANGNAN UNIV
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