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Heteropolyacid iron-based metal-organic framework and its application in xanthine detection

An organic framework and iron-based metal technology, applied in the field of biosensing, can solve the problems of high cost of large-scale application, high cost of raw materials, high degree of pollution, etc., and achieve the effect of reducing detection cost, fast synthesis speed and low price

Active Publication Date: 2022-12-02
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, among the polyacids currently used to detect xanthines, there are still high raw material costs, high pollution levels in the synthesis process, high cost for large-scale application, a large amount of waste water needs to be treated, and there are still needs in terms of detection activity and operability. Further improve

Method used

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  • Heteropolyacid iron-based metal-organic framework and its application in xanthine detection
  • Heteropolyacid iron-based metal-organic framework and its application in xanthine detection
  • Heteropolyacid iron-based metal-organic framework and its application in xanthine detection

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Experimental program
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Effect test

Embodiment 1

[0057] 7.8g ammonium molybdate ((NH 4 ) 6 Mo 7 o 24 4H 2 O, about 6.3mmol) was stirred and dissolved in 120mL boiling distilled water to obtain ammonium molybdate solution. Then 1.8gFe 2 (SO 4 ) 3 ·6H 2 O (about 4.65 mmol) was dissolved in 30 mL of distilled water and added dropwise to the above ammonium molybdate solution with stirring to obtain a dark orange solution which was cooled at room temperature and then filtered. Washed three times with ethanol and ether in the same volume ratio, and dried at room temperature to obtain brown crystals, which were iron-molybdenum heteropolyacids (NH 4 ) 3 [H 6 Fe(III)Mo 6 o 24 ] (sample FeMo 6 ). Carry out infrared spectrum test to iron molybdenum heteropolyacid, test result is as follows figure 1 As shown, FeMo 6 at 943cm -1 、892cm -1 and 649cm -1 The peaks at correspond to the stretching vibrations of Mo-O, Mo-O-Mo and Mo-O-Fe respectively. According to the literature (Nanoscale, DOI: 10.1039 / C8NR00925B), the obta...

Embodiment 2

[0059] 1.89g FeCl 3 ·6H 2 O, 3.15g FeMo 6 Dissolve in 50 mL of distilled water, then add 1.36 g of trimesic acid, and mix evenly to obtain a mixed solution. The mixed solution was charged into a polytetrafluoroethylene-lined stainless steel autoclave, and heated and reacted at 130° C. for three days. Cool to room temperature, filter to obtain an orange solid, filter and wash with an equal volume of ethanol and ether mixed solution, and dry at 70 ° C to obtain an iron-molybdenum heteropolyacid iron-based metal-organic framework material (sample FeMo 6 @MIL-100(Fe)).

experiment example 1

[0064] To the FeMo that makes in embodiment 1 6 , FeMo obtained in Example 26 @MIL-100(Fe) and the MIL-100(Fe) prepared in the comparative example carry out infrared spectrum test, and the test spectrogram is as figure 1 shown. Use Alpha Centaurt FT / IR infrared spectrometer to test, the measurement range is 400 ~ 4000cm -1 (KBr pellets).

[0065] from figure 1 It can be seen that FeMo 6 at 943cm -1 、892cm -1 and 649cm -1 The peaks at correspond to the stretching vibrations of Mo-O, Mo-O-Mo and Mo-O-Fe respectively, indicating that it has an Anderson structure; the vibration absorption of MIL-101(Fe) is located at 711cm -1 、760cm -1 、1380cm -1 、1450cm -1 、1580cm -1 and 1630cm -1 place; in addition, also found that FeMo 6 FeMo also appears in the infrared spectrum of @MIL-100(Fe) 6 and the characteristic peaks of MIL-100(Fe), which shows that FeMo 6 and MIL-100(Fe) were successfully compounded together and Anderson polyacid was not decomposed.

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Abstract

The invention provides a heteropolyacid iron-based metal organic framework material, which is prepared by reacting raw materials including iron-molybdenum heteropolyacid and iron salt I under heating and pressure-holding conditions. There is a good synergistic effect between the iron-molybdenum heteropolyacid and the iron-based metal-organic framework material, so that the heteropolyacid iron-based metal-organic framework material exhibits excellent peroxidase-like activity, and realizes rapid and accurate detection of xanthines. Moreover, the detection condition is easy to control, the operation is simple, and it is favorable for popularization and application.

Description

technical field [0001] The invention belongs to the technical field of biosensing, and in particular relates to a heteropolyacid iron-based metal organic framework material and a preparation method thereof, in particular to the use of the heteropolyacid iron-based metal organic framework material in biosensing for detecting xanthine Applications. Background technique [0002] Xanthine, the metabolic precursor of uric acid, is the most important indicator of abnormal purine profile. Studies have shown that the imbalance of xanthine levels in the human body can lead to various diseases, such as hyperuricemia, gout, xanthinuria, perinatal asphyxia, cerebral ischemia, tumor fever and pre-eclampsia. Therefore, for the sake of human health, detection means must be used to monitor the xanthine level in the body in time to keep it at a normal level. [0003] At present, a variety of methods for the detection of xanthine have been reported, such as electrochemistry, high performanc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/78G01N21/33
CPCG01N21/78G01N21/33
Inventor 汪思奇周晓华辛毅佟俊野刘宏岩侯天远
Owner JILIN UNIV