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New application of sagittaria sagittifolia extract, composition for delaying lens opacity and preparation method of composition

An extract and lens technology, applied in the application field of traditional Chinese medicine, can solve the problems of poor availability of cataract surgery, cost-effective surgery, etc., and achieve the effects of significantly delaying the lens opacity, significant therapeutic effect, and simple preparation method.

Active Publication Date: 2021-10-29
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the only effective way to treat ARC is surgical treatment, but surgery is cost-effective, and there is a huge economic burden, especially in remote and poor rural areas in developing countries where medical resources are scarce, cataract surgery is less accessible, and surgery itself is There are certain risks and complications. Therefore, it is of great significance to find non-surgical measures that are cost-effective and have few side effects to prevent the occurrence and development of ARC and to deal with the grim situation of population aging.

Method used

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  • New application of sagittaria sagittifolia extract, composition for delaying lens opacity and preparation method of composition
  • New application of sagittaria sagittifolia extract, composition for delaying lens opacity and preparation method of composition
  • New application of sagittaria sagittifolia extract, composition for delaying lens opacity and preparation method of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] In vitro cell experiments confirm that sagittarius extract (SSP) helps to protect HLEB3 damage in human lens epithelial cells induced by hydrogen peroxide

[0087] 1 Experimental materials

[0088] 1.1 Experimental cells

[0089] Human lens epithelial cell line HLEB3 cell line (gifted by the Second Affiliated Hospital of Zhejiang University School of Medicine). HLEB3 cells were inoculated in 10% fetal bovine serum, 100U·ml -1 Penicillin and 100U·ml -1Streptomycin in DMEM high glucose medium at 37°C, 5% CO 2 The cells were cultured statically in a saturated humidity cell incubator, digested and passaged with 0.25% trypsin, and the cells in the logarithmic growth phase were used for experiments.

[0090] 1.2 Experimental drugs

[0091] Sagittarius Extract

[0092] 1.3 Experimental reagents and instruments

[0093] 1.3.1 Experimental reagents

[0094] Hydrogen peroxide (H 2 o 2 ) (Beijing Suo Lai Bao Company), trypsin, penicillin streptomycin, PBS (Wuhan Saiweier...

Embodiment 2

[0127] Lens in vitro culture experiment confirms that Sagittarius quince extract helps to delay lens opacity induced by hydrogen peroxide

[0128] 1 Experimental materials

[0129] 1.1 Experimental organization

[0130] Rabbit lens (Japanese big-eared white rabbit, common grade, half male and half male), rat lens (SD rat, half male and half male). The obtained lens was placed in a solution containing 5k U·L -1 Penicillin, 50k U·L -1 Streptomycin M-199 medium, and incubate at 37 °C, 5% CO 2 Cultured statically in a saturated humidity cell incubator. After 24 hours of culture, the transparent lens was selected for subsequent experiments.

[0131] 1.2 Experimental drugs

[0132] Sagittarius Extract

[0133] 1.3 Experimental reagents and instruments

[0134] 1.3.1 Experimental reagents

[0135] Hydrogen peroxide (H 2 o 2 ) (Beijing Suo Laibao Company), carbon dioxide, penicillin streptomycin, PBS, eye fixation solution, (Wuhan Saiweier Biotechnology Co., Ltd.); Medium19...

Embodiment 3

[0178] A composition for delaying lens turbidity, the active ingredients of which are composed of arrowroot extract, rehmannia root extract, rehmannia root extract, wolfberry fruit extract, bletilla striata extract, scrophulariaceae extract, cohosh extract and Alisma extract . Among them, 60kg of Sagittarius extract, 10kg of Rehmannia glutinosa extract, 10kg of Rehmannia glutinosa extract, 10kg of Lycium barbarum extract, 10kg of Bletilla striata extract, 10kg of Radix Scrophulariae extract, 5kg of Cimicifuga extract and 5kg of Alisma extract.

[0179] The preparation method of the above-mentioned composition having the function of delaying lens turbidity, the specific preparation steps are as follows:

[0180] (1) Take Sagittarius extract, Rehmannia glutinosa extract, Rehmannia glutinosa extract, Lycium barbarum extract, Bletilla striata extract, Scrophulariaceae extract, Cimicifuga extract and Alisma extract as raw materials according to the amount of the recipe;

[0181] (...

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Abstract

The invention provides a new application of a sagittaria sagittifolia extract, a composition for delaying lens opacity and a preparation method of the composition. The sagittaria sagittifolia extract has a remarkable treatment effect in the aspects of delaying lens opacity and preventing and treating cataract, can be used for preparing a medicine for delaying lens opacity or preventing and treating cataract, and has important clinical application value. The effective components of the composition consist of the sagittaria sagittifolia extract, a radix rehmanniae preparata extract, a radix rehmanniae extract, a fructus lycii extract, a bletilla striata extract, a radix scrophulariae extract, a rhizoma cimicifugae extract and a rhizoma alismatis extract, all the components have a synergistic effect, and the effect of delaying lens opacity is remarkable. The preparation method is simple, convenient to use and suitable for the requirements of large-scale industrial production.

Description

technical field [0001] The invention relates to the application field of traditional Chinese medicine, in particular to the new use of the sagittarius quince extract, a composition for delaying lens turbidity and a preparation method thereof. Background technique [0002] China is the country with the largest number of cataract blindness. Age-related cataract (ARC) is the most common type of cataract, and its prevalence increases with age. If left untreated, it will eventually develop into severe visual impairment or even blindness, bringing huge health problems and economic burdens to society. [0003] At present, the only effective way to treat ARC is surgical treatment, but surgery is cost-effective, and there is a huge economic burden, especially in remote and poor rural areas in developing countries where medical resources are scarce, cataract surgery is less accessible, and surgery itself is Therefore, it is of great significance to find non-surgical measures that ar...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61K36/898A61K9/48A61K9/16A61P27/02A61P27/12
CPCA61K36/884A61K36/804A61K36/815A61K36/898A61K36/808A61K36/71A61K9/1623A61P27/12A61P27/02A61K2236/331A61K2236/53A61K2236/51A61K2300/00Y02A50/30
Inventor 廖艳刘文胜罗维早张烯
Owner BEIJING UNIV OF CHINESE MEDICINE
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