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A kind of fingerprint determination method of Xiaopihewei capsule

A fingerprint and detection method technology, applied in the field of quality analysis of traditional Chinese medicine, can solve the problems that the quality stability is difficult to guarantee and cannot reflect the quality level of traditional Chinese medicine compound

Active Publication Date: 2022-07-12
贵阳永乐药业有限公司
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Xiaopihewei Capsules are currently included in the National Drug Standards of the State Drug Administration, and its quality control method mainly uses the content determination of a single substance, but the determination and analysis methods for single drug components cannot reflect the overall quality level of the traditional Chinese medicine compound , and its quality stability is difficult to guarantee

Method used

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  • A kind of fingerprint determination method of Xiaopihewei capsule
  • A kind of fingerprint determination method of Xiaopihewei capsule
  • A kind of fingerprint determination method of Xiaopihewei capsule

Examples

Experimental program
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Embodiment 1

[0052] Embodiment 1 The establishment of standard fingerprint of Xiaopihewei capsule

[0053] 1. Instruments and materials

[0054] 1.1 Instruments

[0055] High performance liquid chromatograph (model: U3000, Thermo Fisher Scientific Co., Ltd.), electric heating constant temperature water bath (model: HH-S4A, Beijing Kewei Yongxing Instrument Co., Ltd.); XS105 electronic balance (Sartorius Scientific Instrument (Beijing) Co., Ltd.); Milli-Q ultrapure water purification system (Beijing Wuzhou Oriental Technology Co., Ltd.).

[0056] 1.2 Materials

[0057] Salicin (purity ≥98%, batch number Y12S6S1, Shanghai Yuanye Biotechnology Co., Ltd.), epicatechin (purity ≥98%, batch number 110878-201703, China National Institute for Food and Drug Control), 4-hydroxyacetophenone (purity ≥98%, batch number T21J6C1, Shanghai Yuanye Biotechnology Co., Ltd.), Panax notoginsenoside R1 (purity ≥98%, batch number 110745-201921, China National Institute for Food and Drug Control), ginsenoside R...

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Abstract

The invention discloses a high-performance liquid chromatography (HPLC) fingerprint determination method for Xiaopihewei capsules, which comprises the preparation of a reference solution, the preparation of a test solution, the determination of high-performance liquid chromatography conditions and the establishment of a fingerprint. The fingerprints of Xiaopi and Stomach Capsules obtained by the present invention have 17 common peaks, and 6 components (salicin, epicatechin, 4-hydroxyacetophenone, Panax notoginseng saponin R1, ginsenoside Rg1 and Ginsenoside Rb1). The method of the invention has good stability and good reproducibility, and the established fingerprint of Xiaopihewei capsule can provide a reference for the establishment of its overall quality standard.

Description

technical field [0001] The invention belongs to the technical field of quality analysis of traditional Chinese medicines, and in particular relates to a high-performance liquid chromatography (HPLC) fingerprint determination method for Xiaopihewei capsules. Background technique [0002] Xiaopi Hewei Capsule originated from the Miao nationality and is composed of Geshan Xiao, prickly pear leaves, switchgrass and Panax notoginseng. epigastric pain, vomiting acid water, fullness and noisy embolism. Clinically, it can also be used to treat gastrointestinal diseases such as gastric precancerous lesions and functional dyspepsia. Geshanxiao, also known as Baishouwu, belongs to the spleen, stomach, and kidney meridians, and has pharmacological activities such as digestion and accumulation, nourishing yin and tonifying deficiency, anti-aging, nourishing blood and improving qi. The main active ingredients in Geshanxiao include C21 steroidal saponins and acetophenone compounds, and 4...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/86
CPCG01N30/02G01N30/8686G01N30/8679Y02A50/30
Inventor 向前于泳孙毅坤刘润花
Owner 贵阳永乐药业有限公司
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