Preparation method of water-soluble antibacterial quaternized chitosan/Ag nano composite microspheres

A technology of quaternized chitosan and nano-composite, which is applied in the field of preparation of water-soluble antibacterial quaternized chitosan/Ag nanocomposite microspheres, which can solve the problems that limit the wide application of Ag nanoparticles and the easy aggregation of Ag nanoparticles , Insufficient to meet the antibacterial needs and other issues, to achieve excellent structural stability and antibacterial performance, good water dispersibility, and improve the effect of bonding fastness

Pending Publication Date: 2021-11-05
ZHEJIANG TONGJI VOCATIONAL COLLEGE OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial ability of unmodified chitosan is often weak, which is not enough to meet the complex and changeable antibacterial requirements. The water solubility and antibacterial performance of chitosan modified by quaternization can be significantly improved【Carbohydrate Polymers, 2020, 247,116754−116765.]
Ag nanoparticles are favored because of their broad-spectrum, high-efficiency, and low-drug-resistance antibacterial properties, but Ag nanoparticles are prone to agglomeration and difficult to process, which limits the wide application of Ag nanoparticles to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 2.5 g of nanoparticles (an average size of 18 nm) were added to a mixed solvent of 250 g of water and 250 g of ethylene glycol, and the ultrasonic treatment was administered at 300 W for 20 min, and Ag nanoparticle dispersion was produced, followed by The temperature was adjusted to 30 Oc, adding 3.85 mg of 2-aminethic alcohol solution, reaction 2 h, prepared surface amino-modified Ag nanoparticles, and the product was purified, and the dry was processed. The amino-modified Ag nanoparticles were again dispersed in deionized water, and at the power of 300 W, the ultrasonic treatment was obtained from 20 min to obtain an amino-modified Ag nanoparticle water dispersion.

[0036] The 0.0125 G emulsifier P (E / B) -PEO was sung, dissolved in 12.5 G isometylene alkane (ISOPAR M, Exxon Mobil) to give an emulsifier solution. 0.3 g of quaternized chitosan and 5 mg NaBF4 were dissolved in the Ag nanoparticle water dispersion of 2 g (where the amino-modified Ag nanoparticle content wa...

Embodiment 2

[0041] 0.5 g of nanoparticles (an average size of 15 nm) were added to 250 g of water and 250 g of ethylene glycol, and 10 min was tested at 450 W, and the Ag nanoparticle dispersion was obtained, and then the temperature was adjusted to 30 OC, an ethylene glycol solution containing 1 mg of 2-aminolpropionic acid is added, and the reaction 12 h, the obtained surface amino-modified Ag nanoparticles is added, and the product is purified, and after drying. The amino-modified Ag nanoparticles were again dispersed in deionized water, and at the power of 450 W, the ultrasonic treatment was obtained from the amino-modified Ag nanoparticle water dispersion.

[0042] 1.5 G emulsifier Tween 80 and 1.5 G Sp pan-80, dissolved in 30 g of toluene to give an emulsifier solution. 0.42 g of quaternized chitosan and 8.3 mg NaBF4 were dissolved in 2.5 g of purified Ag nanoparticle water dispersion (where the amino-modified Ag nanoparticle content was 15 mg), the resulting dispersion was added to the...

Embodiment 3

[0047] 0.75 g of nanoparticles (an average size of 20 nm) were added to 250 g of water and 250 g of dimethyl sulfoxide, and 10 min was tested at power of 500 W, and the Ag nanoparticle dispersion was produced, and the temperature was subsequently To 30 OC, a dimethyl sulfoxide solution containing 1.5 mg 2-aminoethiciol was added, and 10 h was added, and the surface amino-modified Ag nanoparticles were added, and the product was purified, and after drying. The amino-modified Ag nanoparticles were again dispersed in deionized water, and at the power of 500 W, the ultrasonic treatment was obtained from the amino-modified Ag nanoparticle water dispersion.

[0048]It is weighed 0.255 G emulsifier P (E / B) -PEO, dissolved in 25.5 g of n-hexadecane to obtain an emulsifier solution. 0.37 g of quaternized chitosan and 8.0 mg Na2SO4 were dissolved in 2.0 g of purified Ag nanoparticle water dispersion (where the amino-modified Ag nanoparticle content was 15 mg), the resulting dispersion was...

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Abstract

The invention discloses a preparation method of a water-soluble antibacterial quaternized chitosan / Ag nano composite microsphere. The method comprises the following steps: carrying out surface amino functionalization modification on Ag nano particles, and carrying out ultrasonic treatment to prepare a uniform Ag nano particle dispersion liquid; adjusting the mass ratio of 2,3-epoxypropyl trimethyl ammonium chloride to chitosan to obtain quaternized chitosan; dissolving a non-polar emulsifier solution, hydrophilic metal salt and quaternized chitosan in the amino-modified Ag nanoparticle aqueous dispersion liquid, and pre-emulsifying to obtain a crude emulsion; and after ice-bath ultrasonic treatment, dropwise adding a cross-linking agent, and reacting under the protection of nitrogen to prepare the water-soluble antibacterial quaternized chitosan / Ag nano composite microspheres. According to the quaternized chitosan / Ag nano composite microspheres and the preparation method thereof disclosed by the invention, a Schiff base structure is formed by reacting aldehyde groups with quaternized chitosan molecules and amino groups on the amino-modified Ag nanoparticles, so that the quaternized chitosan / Ag nano composite microspheres with good colloidal stability and excellent antibacterial performance is prepared.

Description

Technical field [0001] The present invention relates to a preparation method of water-soluble antibacterial quaternized chitosan / AG nanocomposite microspheres. Background technique [0002] There are a wide variety of pathogenic bacteria, and the occurrence of drug-resistant bacteria caused by antibiotic abuse seriously threatens human health and safety, so for safe and efficient, drug-free and degradable antibacterial materials is imminent. [0003] The chitosan has a wide source of sources, good biocompatibility, biodegradable, and is a potential antibacterial alternative material. Unremnivated chitosan antibacterial ability is often weaker, not enough to meet complex and variable antibacterial demand, the aqueous chitosan water solubility and antibacterial properties after quaternization can be significantly improved [Carbohydrate Polymers, 2020, 247, 116754-116765. The AG nanoparticles are favored by its broad spectrum, efficient, low-resistance antibacterial properties, bu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/12C08J3/24C08L5/08C08K9/04C08K3/08
CPCC08J3/12C08J3/24C08J2305/08C08K9/04C08K2003/0806C08K2201/011
Inventor 张梦如刘江湖王鑫杰叶灵涛周森莹欧景华
Owner ZHEJIANG TONGJI VOCATIONAL COLLEGE OF SCI & TECH
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