Preparation method of phenyl sulfide compound

Abstract

The invention discloses a preparation method of a phenyl sulfide compound, which comprises the following steps: by taking thiophenol and o-diiodobenzene as substrates, reacting in a solvent in the presence of a metal hydride to obtain iodine-containing phenyl sulfide; the iodine-containing phenyl sulfide can be subjected to intramolecular reaction to obtain a phenyl sulfide compound; or the iodine-containing phenyl sulfide can react with other raw materials to obtain the phenyl sulfide compound. The ortho-iodine compound prepared by the invention has great application value, can be further widely converted, can be subjected to coupling reaction with phenylboronic acid, thiophenol, phenylacetylene and the like under the catalysis of Pd to prepare various 2-substituted thiophenol, and has important significance in material science and pharmaceutical synthesis.

Description

technical field [0001] The invention belongs to organic synthesis, and in particular relates to a preparation method of phenylene sulfide compound. Background technique [0002] The phenylene sulfide structure widely exists in various active natural medicines and functional materials. The study of the synthesis of thioether compounds has always been the eternal goal of chemists, which is of great significance for the development of innovative drugs and the discovery of new materials. The existing technology uses transition metals to catalyze the coupling reaction, so that the C-S cross-coupling can be easily completed in one step. However, the transition metals are rare and expensive, and the metal reagents remain after the reaction, causing serious pollution problems. Obviously, metal-free C-S coupling synthesis of thioethers is more attractive to researchers; however, the existing schemes usually require harsh conditions such as strong base / high temperature, strong oxidizi...

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Problems solved by technology

The existing technology uses transition metals to catalyze the coupling reaction, so that the C-S cross-coupling can be easily completed in one step. However, the transition metals are rare and expensive, and the metal reagents remain after the reaction and the pollution problem is prominent.

Obviously, metal-free C-S coupling synthesis of thioethers is more attractive to researchers; however, the existing schemes usually require harsh conditions such as strong base / high temperature, strong oxidant, Grignard reagent, or pre-prepared diazonium salt, iodonium , sulfonium and other precursors, the operation is troublesome

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