Winged bean-derived antibacterial and anti-inflammatory betel nut partner molecular capsule liquid and preparation method thereof

Abstract

The invention discloses a winged bean-derived antibacterial and anti-inflammatory capsule, which is prepared by the following steps: (1) soaking picked winged bean rhizomes and leaves in distilled water, cleaning, cutting, naturally airing, drying to constant weight, grinding into powder, and sieving to prepare an active substance microcapsule; (2) extracting functional active substances by an enzymolysis-ultrasonic coupling method; (3) purifying functional active ingredients; (4) embedding functional active substance molecules through polypeptide self-assembly; and (5) preparing the active substance microcapsule. The antibacterial and anti-inflammatory microcapsule disclosed by the invention is high in adhesion, is gel-shaped, can be applied to human skin and the interior of an oral cavity, can be well adhered to the skin and an infected part of the oral cavity, and can be retained in the oral cavity for at least 6 hours due to high anti-washing capacity, so that continuous and efficient anti-inflammatory and antibacterial effects are achieved. The problems of low bioavailability, poor adhesion performance and short retention time of active components in the oral cavity of oral medicines are solved.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to an antibacterial and anti-inflammatory betel nut chaperone molecule capsule liquid derived from four-lens beans and a preparation method thereof. Background technique [0002] Four-edge bean [Psophocarpus tetragonolobus (L.) DC.], also known as wing bean, Goa bean, Nila bean, emperor bean, and fragrant dragon bean, is an annual or perennial climbing herbaceous plant of the Fabaceae family, native to Africa and Southeast Asia It has been introduced to my country for more than 100 years in the tropical humid area. It is mainly distributed in Yunnan, Guangxi, Qiong, Guangdong and other southern provinces. It is mostly used as fresh vegetables and is called green gold vegetables. The aboveground part of the four-lens bean blooms and sets pods, and the underground grows tubers. Its seeds, roots, shoots, young leaves and flowers are all edible, rich in nutrition, and have certain medi...

AI Technical Summary

Problems solved by technology

Antibiotics are commonly used drugs to treat bacterial infections. The antibiotics and chemical bacteriostatic agents currently used to treat bacterial infections will interfere with the normal bacterial flora in the oral cavity and digestive tract. In addition, the continuous flushing effect of saliva makes it difficult to maintain an effective concentration of drugs in the oral cavity , so to improve the bioavailability and retention of antibacterial agents in biofilms, it is urgent to develop new delivery systems

Polymeric drug carriers can protect the stability and integrity of therapeutic molecules, deliver drugs to desired targets and release drugs, and reduce side effects on other organs. The development of oral bacterial infection treatment methods is still challenging.

Images