11results about How to "Strong support" patented technology

The invention discloses a preparation method of an arfamarana key intermediate, which comprises the following steps: carrying out nucleophilic addition reaction on a compound I and 1-[3-chloro-5-(trifluoromethyl) phenyl]-2, 2, 2-trifluoroethanone under the action of an organic solvent A and alkali to obtain a compound II; dissolving the compound II in an organic solvent B, adding concentrated sulfuric acid, carrying out intramolecular dehydration and cyanogen hydrolysis, and after the reaction is finished, cooling to room temperature for crystal growing to obtain a compound III; dissolving the compound III in an organic solvent C, carrying out intramolecular cyclization and ester hydrolysis reaction on the compound III and hydroxylamine hydrochloride under the action of a certain amount of sodium hydroxide aqueous solution, and after the reaction is finished, collecting a water phase and adjusting the pH value of the water phase, so as to obtain the key intermediate of arfampanaga. The reaction in each step has a high conversion rate, the purity of the prepared arfamarin intermediate is high, and powerful support and guarantee are provided for preparation of high-purity arfamarin.

The utility model relates to the technical field of steel pipe processing, and discloses a sectional type seamless steel pipe quenching device which comprises a base, a fixed seat is fixedly connected to the front end of the top of the base, a flexibly-adjusted quenching assembly is arranged above the base and comprises a quenching box, electric push rods are fixedly connected to the two sides of the bottom end of the quenching box, and the electric push rods are fixedly connected to the two sides of the bottom end of the quenching box. The bottom end of the electric push rod is fixedly connected with the top end of the base, and the rear end of the top of the base is fixedly connected with a fixing plate. According to the sectional type seamless steel pipe quenching device, by arranging the fixing plate, the electric push rod, the movable base, the quenching box and the sliding rail, heating and cooling sectional treatment is achieved, the working efficiency of equipment is improved, the situation that the quenching box shakes due to insufficient stabilizing force during cooling is avoided, and the problem that due to the fact that the distance between the heating function and the cooling function of the quenching device is long is solved. The service efficiency of the device is reduced due to the fact that segmented treatment cannot be conducted, and meanwhile the machining effect is affected due to the low adaptability of the device.

The invention discloses a pharmaceutical composition for enhancing the killing power of CIK cells to tumor cells and application, and belongs to the technical field of biological medicine. The pharmaceutical composition is composed of a PD-1 monoclonal antibody and a protein phosphatase PP2A inhibitor, the PD-1 monoclonal antibody is Pembrolizumab, the protein phosphatase PP2A inhibitor is LB100, and the mass ratio of the PD-1 monoclonal antibody to the protein phosphatase PP2A inhibitor is (100-10): 1. Through combined use of the PD-1 monoclonal antibody and the protein phosphatase PP2A inhibitor LB100, by adjusting related signal channels in the CIK cells, immunosuppression of tumor cells on the CIK cells is relieved, the killing activity of the CIK cells on the tumor cells is remarkably improved, more powerful immune cell support is provided for tumor treatment, and good clinical application prospects are achieved.

The utility model discloses a kind of anticorrosive structures of concrete pool, the anticorrosive structure includes a concrete pool main body and a anticorrosive structure main body being set in the concrete pool main body, the anticorrosive structure main body includes sequentially connected from bottom to top: a reinforced concrete component layer being fixedly connected at the bottom of the concrete pool main body;A waterproof layer;A first vinyl resin layer;A glass fiber short-cut felt layer;A second vinyl resin layer;A first glass fiber layer;A third vinyl resin layer;A second glass fiber layer;A fourth vinyl resin layer;A third glass fiber layer;And a fifth vinyl resin layer.The utility model effectively solves the problem that the anticorrosive force of existing concrete pool is limited, and corrosion failure is likely to occur during long-term use, and concrete pool is also likely to crack and permeate, which affects normal use.

The utility model relates to hyperbolic aluminum veneer technical field discloses the special-shaped hyperbolic aluminum veneer for outer wall decoration, including special-shaped hyperbolic aluminum veneer, the surface fixedly connected with the installation branch board of special-shaped hyperbolic aluminum veneer, the inner wall fixedly connected with the fixed support machine of special-shaped hyperbolic aluminum veneer, the inside of fixed support machine is inserted with the reinforcing branch board, the inside screw thread connection with the installation screw rod of reinforcing branch board, the surface screw thread connection with the limiting board of installation screw rod, the top sliding connection with the lifting shell of special-shaped hyperbolic aluminum veneer. The utility model discloses through setting up the lifting gear in the inside of special-shaped hyperbolic aluminum veneer, and the rotating handle is located in the inside of special-shaped hyperbolic aluminum veneer, and the surface of rotating handle is contacted with the surface of lifting shell, so that the user can easily control the rotation of lifting gear through rotating handle, thereby realizes the up and down movement of lifting pillar, and the operation is simple and convenient, makes the support stability after special-shaped hyperbolic aluminum veneer installation.

The present application relates to a kind of interactive supervision method of new intent discovery in human-computer conversation system, belong to natural language processing technical field.The present application solves the problem that existing method cannot be well combined parameter clustering and representation learning.Its implementation steps are as follows: (1) obtain data set;(2) the original data is divided into marked known intent data and unmarked unknown intent data, and the data set is preprocessed;(3) pretraining of known intent data, capture the nature of known intent data;(4) unknown intent data clustering is carried out by interactive learning;(5) representation learning is improved by parameter clustering;(6) representation learning is used to improve parameter clustering.By using semantic similarity from representation learning branch to regularize parameter clustering branch, the method of the present application can more accurately identify unknown intent, improve the performance and efficiency of new intent discovery task.

The utility model provides an eight-layer high-frequency circuit board. The laminated board sequentially comprises a first solder mask layer, a first copper layer, a first prepreg layer, a second copper layer, a first core board layer, a third copper layer, a second prepreg layer, a fourth copper layer, a middle layer, a fifth copper layer, a third prepreg layer, a sixth copper layer, a second core board layer, a seventh copper layer, a fourth prepreg layer, an eighth copper layer and a second solder mask layer from top to bottom, the middle layer comprises a third core plate, a heat dissipation ceramic frame and a fourth core plate, a hollow cavity is formed in the position, close to a high heat area of the circuit board, of the heat dissipation ceramic frame, a first aluminum-based heat dissipation sheet is embedded and fixed in the hollow cavity, and the upper surface of the first aluminum-based heat dissipation sheet is in contact with the third core plate in an attached mode; the lower surface of the first aluminum-based radiating fin is attached to and contacted with the fourth core plate; a plurality of embedding grooves are formed in the side face, corresponding to the first aluminum-based cooling fins, of the first core plate layer, and second aluminum-based cooling fins are arranged in the embedding grooves in an embedded mode. And the overall heat dissipation efficiency of the circuit board is improved.

The invention discloses an application of ginsenoside Ro in preparation of a medicine for treating cerebral ischemia-reperfusion injury. According to the application disclosed by the invention, by preparing a middle cerebral artery occlusion / reperfusion (MCAO) mouse model, the ginsenoside Ro is found to be capable of reducing the cerebral infarction volume of the model mouse, improving the pathological injury of brain tissues and increasing the cerebral blood flow at the ischemic side. Meanwhile, the ginsenoside Ro up-regulates the expression of brain tissue tight junction proteins ZO-1 and Occludin, inhibits the expression of matrix metalloproteinase MMP-9 / 2, reduces the leakage amount of Evans blue, and improves the blood brain barrier (BBB) dysfunction. Besides, by preparing an oxygen glucose deprivation / reperfusion (OGD / R) induced mouse brain microvascular endothelial cell line 3 (bEnd.3) cell model, it is found that the ginsenoside Ro can improve the damage of the barrier function of the bEnd.3 cell induced by the OGD / R, it is proved that the ginsenoside Ro can be used for the novel medical application of treating the cerebral arterial thrombosis, and the ginsenoside Ro has a wide application prospect.

The utility model relates to the technical field of supporting structures, in particular to a formwork supporting frame capable of precisely adjusting elevation, which comprises a supporting pipe, a supporting rod, a connecting rod, a connecting rod and a connecting rod. The supporting rod is inserted into the supporting pipe, bolt holes are formed in the supporting rod at intervals, part of the supporting rod extends out of a pipe opening in the top end of the supporting pipe, a threaded connection section is arranged at the end, extending out of the supporting pipe, of the supporting rod, the length of the threaded connection section is larger than the distance between every two adjacent bolt holes, and the length of the extending part of the supporting rod is adjustable; the positioning plug pins can be inserted into the inserting holes in the supporting pipes and the corresponding plug pin holes in the supporting rods; the adjusting sleeve is in threaded connection with the threaded connection section, a template supporting surface is arranged at the top, and the adjusting sleeve can move up and down relative to the supporting rod by rotating the adjusting sleeve. The formwork supporting frame has two height adjusting modes, the adjusting range can be widened, and the supporting strength of the formwork supporting frame is guaranteed.

The application relates to a local-global time sequence interaction network for unilateral directional motor imagery electroencephalogram decoding, and belongs to the technical field of brain-computer interfaces. The method comprises the following steps: a shallow CNN module is used to extract a localized time-frequency representation from an original EEG signal; a multi-scale time sequence feature extraction and compression module is used to extract complementary features through four parallel time sequence processing paths of a short time sequence convolution kernel, a long time sequence convolution kernel, an average pooling layer and a step convolution layer; a multi-scale fusion feature is reduced in dimension based on a deep separable convolution; a local-global time attention module is used to replace fixed position coding with learnable position coding in an encoder, model global time sequence dependence, perform adaptive average pooling on a segmentation length based on a time pyramid pooling module, and output multi-scale local features and splice. The organic fusion of multi-scale local features and global time sequence dependence features is realized, and the decoding performance of unilateral directional motor imagery electroencephalogram signals is effectively improved.

This invention provides a vehicle trajectory prediction method, apparatus, electronic device, and storage medium. The method includes: predicting first driving state information of the first vehicle when it is no longer detected by a target radar; the first driving state information indicates whether the first vehicle tends to remain stationary or move laterally away after disappearing from the target radar's detection results; if the first driving state information indicates that the first vehicle tends to remain stationary, then determining first motion state information of the first vehicle; the first motion state information indicates the first position and first speed of the first vehicle queuing in the target lane when it begins to disappear from the target radar's detection results; and predicting second motion state information of the first vehicle based on the first motion state information for trajectory tracking prediction. This solution addresses the problem of low vehicle detection rate when starting in queuing scenarios at intersections.