Anti-swelling biological adhesive as well as preparation method and application thereof

A bio-adhesive and anti-swelling technology, applied in the field of medical materials, can solve the problems of poor performance of bio-adhesives, achieve good anti-swelling performance, ensure adhesion stability, and good adhesion performance

Active Publication Date: 2021-11-19
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above deficiencies in the prior art, the object of the present invention is to provide an anti-swelling bioadhesive and its preparation method and application, aiming at solving the problem of poor performance of existing bioadhesives under extreme conditions

Method used

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  • Anti-swelling biological adhesive as well as preparation method and application thereof
  • Anti-swelling biological adhesive as well as preparation method and application thereof
  • Anti-swelling biological adhesive as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Hydrogel substrate preparation scheme optimization technical route:

[0051] The anti-swelling performance of the hydrogel substrate is the key, and the choice of acrylate plays a decisive role. This program takes hydroxyethyl methacrylate (HEMA) as a case example to illustrate the preparation method of the substrate hydrogel. After selecting the HEMA, N-vinylpyrrolidone (NVP) was introduced to adjust the mechanical properties of the hydrogel substrate and optimize the polymerization conditions. Mix HEMA and NVP according to the ratio shown in Table 1, and control the total weight to 20wt%. After mixing the small molecule monomers, add crosslinking agent (PEG(m)-DMA) and photoinitiator (both use 0.5wt% I2959) at one time, then use the rotation and revolution instrument to carry out further mixing and defoaming treatment, and pour Nitrogen gas was introduced into the mold before oxygen removal treatment. In the mold with a set thickness, the polymerization reaction was ...

Embodiment 2

[0060] The optimized technical route for the preparation of hydrogel substrates with bioadhesive properties:

[0061] In order to introduce the polymer with bioadhesive properties into the anti-swelling substrate, the present invention designs by enriching the photoinitiator on the film surface of the hydrogel substrate, and then soaking in the monomer solution dissolved with AA and AA-NHS, The PAA-NHS macromolecular polymer was prepared by ultraviolet light-induced polymerization, which was embedded in the hydrogel substrate through a penetrating method, and a layer of polymer brushes grew on its surface at the same time. The optimization of the photoinitiator, the ratio of AA and AA-NHS, and the optimization of the reaction time are designed in this technical route. Table 3 is the optimization of the photoinitiator BP; Table 4 is the optimization of the factors affecting the polymerization of AA and AA-NHS.

[0062] Table 3: Optimization of photoinitiator BP

[0063] ...

Embodiment 3

[0069] Bioadhesive water content and swelling rate test

[0070] The bioadhesive was cut into cubes 2 cm long, 2 cm wide, and 5 mm thick. Soak in PBS solution with pH 2.0, take them out at different times (8, 24, 72, 120 and 240 h), weigh them after removing the surface free water, and finally calculate their water content and swelling rate. Test results such as image 3 and shown in Table 5.

[0071] Table 5: Measurement results of bioadhesive swelling properties

[0072] Soaking time (h) Water content (wt%) Swelling rate (%) 0 0 100 8 69.9 302 24 75.7 412 72 77.3 441 120 77.6 447 240 78.1 451

[0073] The bioadhesive is soaked in an acidic buffer (pH 2.0), and remains stable after absorbing water within 24 hours to reach the swelling equilibrium, and continues to monitor for 10 days. The results show that when the adhesive reaches the swelling equilibrium, the water content is still lower than 80wt%. , is not free t...

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Abstract

The invention discloses an anti-swelling biological adhesive and a preparation method and an application thereof. The anti-swelling biological adhesive comprises a hydrogel substrate and a high-molecular polymer brush combined to the surface of the hydrogel substrate, the hydrogel substrate is prepared through a polymerization reaction of an acrylate compound and N-vinyl pyrrolidone, and the high-molecular polymer brush is prepared by carrying out polymerization reaction on acrylic acid and acrylic acid-N-succinimide ester. The anti-swelling biological adhesive provided by the invention has excellent comprehensive performance, and shows good adhesion performance, mechanical performance matched with tissues, good anti-swelling performance and biocompatibility in a wet environment. Therefore, the anti-swelling biological adhesive disclosed by the invention has wide biomedical prospects in the aspects of blocking and suturing wounds in extreme water environments such as gastrointestinal tracts and the like, tissue repair and the like.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an anti-swelling biological adhesive and its preparation method and application. Background technique [0002] Bioadhesive (including tissue adhesion, hemostatic agent and tissue sealant) is a biomedical material used to prevent tissue adhesion, hemostasis, and air and body fluid leakage during surgery. Compared with traditional sutures, rivets and other mechanical fixation materials, bioadhesives have the advantages of convenient use, easy operation, non-invasive closure, minimal surgical invasion, less pain, and inhibition of body fluid leakage in postoperative wound suture, tissue regeneration, and wound healing. And to a great extent avoid the secondary trauma caused by wound suture and other advantages. Therefore, its development caters to the development concept of modern medicine and surgical suture, and has broad application prospects in clinical use. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00C08F285/00C08F220/06C08F220/36C08F283/06C08F220/20C08F226/10
CPCC08F285/00C08F283/065A61L24/06A61L24/0031A61L24/001C08F220/06C08F220/365C08F220/20C08F226/10C08L33/14C08L39/06
Inventor 刘吉陈兴梅张俊薛羽林景森吴德成
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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