Preparation method of gel dressing containing silk fibroin

Abstract

The invention discloses a preparation method of a gel dressing containing silk fibroin. The gel dressing is prepared from the following components in parts by weight: 2-10 parts of silk fibroin, 3-6 parts of earthworm protein, 2-4 parts of phycocyanin, 6-10 parts of N-acetyl-D-glucosamine, 1-4 parts of carbomer, 3-6 parts of hydroxyethyl cellulose, 3-7 parts of fatty acid, 2-5 parts of gelatin, 1-3 parts of sodium chloride, 2-5 parts of propylene glycol, 2-6 parts of hyaluronic acid, 1-6 parts of sodium benzoate, 2-8 parts of Tween-80, 1-3 parts of radix arnebiae seu lithospermi, 4-6 parts of herba menthae and 20-40 parts of purified water. By matching the silk fibroin with the earthworm protein, the phycocyanin, the N-acetyl-D-glucosamine, the carbomer and the hydroxyethyl cellulose, the effects of nutrient repair, tissue regeneration and biocompatibility can be fully exerted, so that the product provides a good microenvironment on the premise of inhibiting germs and promoting tissue repair and regeneration, a protective film is formed, pathogenic microorganisms are prevented from colonization, and the effects of nutrient repair of skin tissues, promotion of tissue growth, protection of wound surface microenvironment, environment cleaning, water locking, moisturizing and the like are achieved.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a preparation method of a gel dressing containing silk fibroin. Background technique [0002] Silk fibroin (SF) is a protein extracted from silk. It is similar to collagen in bones. It has certain biodegradability. The degradation products have no toxic and side effects, and have nutrition and repair effects on surrounding tissues. The source of the material is broad. Its basic structure is composed of tight and neat crystalline regions and loose and disordered non-crystalline regions, in which the crystalline regions are mainly residues of glycine, alanine and serine, and the non-crystalline regions are mainly composed of phenylalanine, tyrosine, Tryptophan and other amino acid residues. Silk protein contains a kind of "hydrophilic side chain amino acid", which can absorb sweat and water from the human body and remove it, so as to keep it dry and breathable. It has t...

AI Technical Summary

Problems solved by technology

Studies so far have fully proved that silk fibroin has good biocompatibility when used in wound dressings, which provides a solid foundation for its safe clinical application. Different types of wounds have different structures, physical and chemical properties and biological properties of dressings There are different requirements for performance. The research and development of silk fibroin dressings suitable for chronic and refractory wounds such as infection, ulcers, and diabetic feet needs to be further developed. On the basis of fully understanding the healing pathways and molecular mechanisms of different types of wounds, targeted The composition, structure, physical and chemical properties and biological activity design of silk fibroin wound dressings should be carried out carefully, so that silk fibroin wound dressings can also have the functions of accelerating wound healing speed and improving wound healing quality, which is the focus of future research and development