Preparation method and application of medical ultra-high molecular weight poly (p-dioxanone)
A technology of poly-p-dioxanone and p-dioxanone, which is applied in the field of medical material manufacturing, can solve the problems of waste of monomers, high proportion of catalysts, destruction of regularity, etc., so as to avoid solvent residues and achieve biocompatibility. High performance, preventing thermal degradation
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[0029] This embodiment discloses a preparation method of medical ultra-high molecular weight polydioxanone, comprising the following steps:
[0030] 1) purifying p-dioxanone;
[0031] Preferably, p-dioxanone is purified by solvent-free crystallization. Specifically, heat the p-dioxanone to make it liquid, and crystallize at 0-30° C. After the crystallization is completed, pour out the uncrystallized part to obtain purified p-dioxanone; Purity monomer, using stannous octoate with high biological safety as a catalyst, obtained ultra-high molecular weight polydioxanone, which meets the requirements for the mechanical strength of medical devices; solvent-free crystallization, the purity of the monomer after purification Higher, and avoid solvent residue, the prepared polymer biocompatibility is higher;
[0032] 2) Polymerization reaction: the reactor is heated and inert gas is poured into it, the purified p-dioxanone prepared in step 1) is added, and a catalyst and an alcohol in...
Embodiment 1
[0040] Monomer purification: heat p-dioxanone monomer until it becomes liquid completely, then crystallize at 15°C for 24 hours, and pour out the uncrystallized part;
[0041] Polymerization: Heat the reactor to 130°C, pump nitrogen to make the inside of the reactor an inert atmosphere, add 2000g of purified monomer, 0.786g of stannous octoate, and 0.365g of dodecanol to react for 4 hours, then raise the stirring rod, The reaction was continued for 24 hours at 80°C.
[0042] Discharge: Turn the stirring blade into plunger mode, push out the material and cool it with liquid nitrogen;
[0043] Pulverization: Use a pulverizer to pulverize the material into small particles;
[0044] Monomer removal: put the pulverized material in a vacuum container, and remove the monomer at 60°C;
[0045] Results: The molecular weight of the prepared polymer was 780,000.
Embodiment 2
[0047] Monomer purification: heat p-dioxanone monomer until it becomes liquid completely, then crystallize at 23°C for 48 hours, and pour out the uncrystallized part;
[0048] Polymerization: Heat the reactor to 120°C, pump nitrogen to make the inside of the reactor an inert atmosphere, add 2000g of purified monomer, 0.524g of stannous octoate, and 0.243g of dodecanol to react for 6 hours, then lift the stirring rod, Continue to react for 24 hours at 80°C;
[0049] Discharge: Turn the stirring blade into plunger mode, push out the material and cool it with liquid nitrogen;
[0050] Pulverization: Use a pulverizer to pulverize the material into small particles;
[0051] Monomer removal: put the pulverized material in a vacuum container, and remove the monomer at 60°C;
[0052] Results: The molecular weight of the prepared polymer was 950,000.
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