Multi-dimensional lip-enlarging composition as well as preparation method and application thereof
A composition and multi-dimensional technology, applied in the direction of pharmaceutical formulations, dressing preparations, cosmetic preparations, etc., can solve the problem of lack of mild and long-lasting three-dimensional lip-enhancing products, so as to save product costs, reduce usage, and promote blood circulation. loop effect
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[0044] A multidimensional lip-enhancing composition, characterized in that the composition comprises the following parts by mass: 0.1-1 part of oil-soluble brown algae extract, 0.1-2 parts of dipalmitoyl hydroxyproline, and oil-soluble hyaluronic acid 0.1-5 parts of sodium, 0.02-0.1 parts of vanillyl butyl ether, and 4-16 parts of ester solvents.
[0045] The brown algae extract was prepared using the following steps:
[0046] Step 1, the root of the brown algae is broken and crushed, and soaked in 95% ethanol solution for 20 hours at a solid-to-liquid ratio of 1:1.2g / ml to obtain a mixed solution;
[0047] Step 2, adding the mixed solution into the extraction kettle, feeding supercritical carbon dioxide into the extraction kettle, controlling the temperature at 36°C, controlling the pressure at 40Mpa, and the time is 2.5 hours;
[0048] The third step is to introduce the carbon dioxide fluid containing the brown algae extract flowing out of the extraction kettle into the sep...
experiment example 1
[0058] Experimental example 1. Zebrafish test
[0059] Zebrafish and human genes have a high homology of 87%. As a model organism, the advantage is very prominent, and it is an important experimental animal.
[0060] Divide the zebrafish into several groups, the blank control group without any treatment, the negative control group quantitatively added PEG-60 hydrogenated castor oil to the fish water, and the experimental group quantitatively added the ingredients from Experimental Examples 1 to 10 and Comparative Example 1 to the fish water. ~5 The prepared lip plumping composition is dissolved in a 0.1% concentration solution of PEG-60 hydrogenated castor oil. After 24 hours, relevant indicators were measured.
[0061] Evaluation of blood microcirculation: The blood flow velocity of zebrafish in each group was analyzed and observed by a blood flow analyzer.
[0062] The result is as figure 1 Shown:
[0063] 1) It can be known from all the test results that, except capryli...
experiment example 2
[0074] Experimental example 2. Lip fullness test
[0075] Test sample: lip film prepared using 2% of the composition of Example 12, Comparative Examples 1-5, hyaluronic acid and collagen
[0076] Test equipment: Antera 3D (Miravex, Ireland)
[0077] Test objects: Female volunteers aged 20-40, 5 people in each group
[0078] testing method:
[0079] 1. Before using the product, use Antera 3D to measure the volume of the protruding part of the lip line;
[0080] 2. Use the product once a day in the morning and evening;
[0081] 3. Immediately and 28 days after the product is used, use Antera 3D to measure the volume of the protruding part of the lip, and calculate the average increase or decrease rate.
[0082] The result is as follows Figure 4 Shown:
[0083] From the test results, it can be seen that the lip-enhancing composition of the present invention has both immediate and long-lasting lip-enhancing effects significantly better than those of Comparative Examples 1-5...
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