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A kind of micro-current unidirectional wet drug-carrying sustained-release fiber membrane and preparation method thereof

A technology of unidirectional moisture transfer and fiber membrane, which is applied in fiber processing, medical science, bandages, etc., can solve the problems of no sustained release effect, high cost of fiber membrane, and inability to export tissue fluid, etc., to achieve simple and easy to obtain raw materials, easy operation, Effects in simple steps

Active Publication Date: 2022-07-12
ANHUI POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Commonly used wound dressings are made of gauze or synthetic fibers, etc. During the treatment of skin surface wounds, tissue fluid seeps out continuously. Using existing dressing materials, tissue fluid can be absorbed by the dressing material, but the traditional dressing The side of the material close to the skin cannot export the tissue fluid out in time, resulting in the wound skin not being able to keep dry
[0004] In the prior art, some researchers use cellulose acetate to prepare cellulose acetate membrane, which has a certain moisture-conducting effect and can export interstitial fluid. However, cellulose acetate is used as raw material for cellulose acetate, and cellulose acetate needs to be prepared by itself, and the cost of the fiber membrane is relatively high. High, and found that this cellulose acetate membrane can only provide a certain protective effect, can not promote wound healing, and the drug action time is short, no sustained release effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] The present invention also provides the preparation method of the micro-current unidirectional moisture-conducting drug-carrying sustained-release fiber membrane described in the above scheme, comprising the following steps:

[0027] The polyvinyl alcohol-glutaraldehyde mixed aqueous solution is electrospinned, and the obtained fiber membrane is placed in an HCl atmosphere for cross-linking to obtain a hydrophilic fiber membrane;

[0028] Electrospinning the polyvinylidene fluoride solution containing the drug, and using the hydrophilic fiber membrane for receiving, so that the drug-loaded hydrophobic fiber membrane is deposited on the surface of the hydrophilic fiber membrane to obtain the microcurrent unidirectional wet-carrying drug-loaded sustained release fibrous membrane.

[0029] In the present invention, the polyvinyl alcohol-glutaraldehyde mixed aqueous solution is electrospinned, and the obtained fiber membrane is placed in an HCl atmosphere for cross-linking ...

Embodiment 1

[0034] The glutaraldehyde-polyvinyl alcohol mixed aqueous solution was used for electrospinning. The concentration of polyvinyl alcohol in the mixed aqueous solution was 10%, and the concentration of glutaraldehyde was 1.5%. Electrospinning parameters: the spinning voltage was 15kV, and the advancing speed was 0.8ml / h, the receiving distance is 20cm, the rotation speed of the drum is 60rpm, and the spinning time is 1h. The obtained fiber membrane had a water contact angle of 0°, a fiber diameter of 224 ± 35 nm, and a fiber membrane thickness of 75 ± 15 μm.

[0035] The fiber membrane obtained by electrospinning was placed in a vacuum reactor, and the fiber membrane was cross-linked with HCl vapor for 3 hours to obtain a cross-linked polyvinyl alcohol fiber membrane (ie, a hydrophilic fiber membrane), and a cross-linked polyethylene The water contact angle of the alcohol fiber membrane is 0°, and it is insoluble in water.

[0036] The cross-linked polyvinyl alcohol fiber film ...

Embodiment 2

[0041] The glutaraldehyde-polyvinyl alcohol mixed aqueous solution was used for electrospinning. The concentration of polyvinyl alcohol in the mixed aqueous solution was 13%, and the concentration of glutaraldehyde was 1.7%. Electrospinning parameters: the spinning voltage was 18kV, and the advancing speed was 1ml / h, the receiving distance is 20cm, the rotation speed of the drum is 60rpm, and the spinning time is 1h. The water contact angle of the obtained fiber membrane was 0°, the fiber diameter was 313 ± 41 nm, and the fiber membrane thickness was 81 ± 12 μm.

[0042] The fiber membrane obtained by electrospinning was placed in a vacuum reactor, and the fiber membrane was cross-linked with HCl vapor for 3 hours to obtain a cross-linked polyvinyl alcohol fiber membrane (ie, a hydrophilic fiber membrane), and a cross-linked polyethylene The water contact angle of the alcohol fiber membrane is 0°, and it is insoluble in water.

[0043] The cross-linked polyvinyl alcohol fiber...

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Abstract

The invention relates to the technical field of wound dressings, and provides a microcurrent unidirectional wet drug-carrying sustained-release fiber membrane and a preparation method thereof. The microcurrent unidirectional moisture-conducting drug-loaded sustained-release fiber membrane provided by the present invention is a double-layer membrane structure, including a hydrophilic fiber membrane and a drug-loaded hydrophobic fiber membrane; the hydrophilic fiber membrane is a polyvinyl alcohol-glutaraldehyde cross-linked membrane ; The material of the drug-loaded hydrophobic fiber membrane is polyvinylidene fluoride. The micro-current unidirectional moisture-conducting drug-carrying slow-release fiber membrane provided by the present invention is a double-layer membrane structure, wherein the drug-carrying hydrophobic fiber membrane is close to the skin, and can release the drug slowly to the wound on the skin surface; at the same time, the tissue fluid generated by the wound can pass through The hydrophobic fiber membrane conducts unidirectionally to the hydrophilic fiber membrane without reverse osmosis, which is beneficial to keep the skin near the wound dry; in addition, the drug-loaded hydrophobic fiber membrane close to the skin is made of polyvinylidene fluoride, which has frictional properties. Electrical properties, can generate micro-current when rubbed against the skin, which helps wound healing.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a microcurrent unidirectional moisture-carrying drug-carrying sustained-release fiber membrane and a preparation method thereof. Background technique [0002] Wound dressing is a product used to wrap wounds to cover the wound surface, absorb exudates, and provide protection for the wound surface. [0003] Commonly used wound dressings are made of gauze or synthetic fibers. When treating wounds on the skin surface, there is continuous exudation of tissue fluid. Using the existing dressing materials, the tissue fluid can be absorbed by the dressing material, but the traditional wrapping The side of the material close to the skin cannot export the tissue fluid out in time, resulting in the wound skin being unable to keep dry. [0004] In the prior art, researchers use cellulose acetate to prepare cellulose acetate membrane, which has a certain moisture-conducting effect and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/24A61L15/20A61L15/42A61L15/44D01D5/00D04H1/728
CPCA61L15/24A61L15/20A61L15/42A61L15/44D01D5/0015D01D5/0084D04H1/728A61L2300/602A61L2300/412C08L29/04C08L27/16
Inventor 王洪杰王赫曹秋云胡忠文孙冉吕明宏
Owner ANHUI POLYTECHNIC UNIV