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Method for removing protein from acarbose plate frame filtrate

A technology for acarbose and protein removal, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve problems affecting production efficiency, weakening resin adsorption capacity, and increasing environmental protection treatment pressure, etc., to achieve The effect of reducing the amount of regeneration acid and alkali and water consumption, reducing the content of viscous protein, and reducing production costs

Pending Publication Date: 2021-12-17
同舟纵横(厦门)流体技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Acarbose is produced by motile actinomycetes through fermentation, and the plate and frame filtrate obtained after the fermentation broth is filtered through the plate and frame is directly submitted to the subsequent resin adsorption treatment to extract acarbose; due to the poor filtration accuracy of the plate and frame, the plate and frame filtrate The quality is poor, and there are often a large amount of protein and suspended solids in the filtrate; resulting in the plate and frame filtrate directly entering the resin adsorption process, the resin adsorption capacity is weakened, the resin is often blocked, and a large amount of acid-base regeneration is required, which affects production efficiency while consuming acid-base. Increased wastewater discharge and increased pressure on environmental protection

Method used

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  • Method for removing protein from acarbose plate frame filtrate
  • Method for removing protein from acarbose plate frame filtrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1) Collect the acarbose plate and frame filtrate during the bio-fermentation production process of a certain pharmaceutical company in Hebei. The mass content of acarbose in the acarbose plate and frame filtrate is 2%-5%.

[0039] 2) The acarbose plate and frame filtrate obtained in step 1) is subjected to precision filtration (with a precision of 100 microns), then pressurized to 0.3 MPa, and the ceramic membrane is used to remove protein, and the temperature of the ceramic membrane to remove protein is 20-25°C , when the concentration ratio is 7:1, the ceramic membrane dialysate is obtained.

[0040] The obtained ceramic membrane dialysate can be further processed with resin.

[0041] According to the base of 80 tons of acarbose plate and frame filtrate per day, the use of the above-mentioned ceramic membrane filtration saves 80 tons of water per day, 5 tons of hydrochloric acid consumption, and 4 tons of sodium hydroxide consumption, which translates into a cost of ...

Embodiment 2

[0043] 1) Collect the acarbose plate and frame filtrate from the biological fermentation process of a pharmaceutical company in Guangzhou. The mass content of acarbose in the acarbose plate and frame filtrate is 2%-3%.

[0044] 2) The acarbose plate and frame filtrate obtained in step 1) is subjected to precision filtration (with a precision of 60 microns), then pressurized to 0.4 MPa, and the ceramic membrane is used to remove protein, and the temperature of the ceramic membrane to remove protein is 20-25°C , when the concentration ratio is 6:1, the ceramic membrane concentrate and the ceramic membrane dialysate are obtained.

[0045] 3) The ceramic membrane dialysate obtained above is further processed to produce resin. According to the base of 50 tons of acarbose plate and frame filtrate per day, 40 tons of water, 3 tons of hydrochloric acid and 2 tons of sodium hydroxide are saved every day, which translates into a cost of about 26,000 yuan.

[0046] The obtained ceramic m...

Embodiment 3

[0048] 1) Collect the acarbose plate and frame filtrate from the bio-fermentation process of a Zhuhai Pharmaceutical Co., Ltd. The mass content of acarbose in the acarbose plate and frame filtrate is 2%-3%.

[0049] 2) The acarbose plate and frame filtrate obtained in step 1) is subjected to precision filtration (with a precision of 50 microns), then pressurized to 0.5 MPa, and the ceramic membrane is used to remove protein. The temperature of the ceramic membrane to remove protein is 20-25°C , when the concentration ratio is 6:1, the ceramic membrane concentrate and the ceramic membrane dialysate are obtained.

[0050] 3) The ceramic membrane dialysate obtained above is further processed to produce resin. According to the base of 100 tons of acarbose plate and frame filtrate per day, 120 tons of water, 8 tons of hydrochloric acid, and 9 tons of sodium hydroxide are saved every day, which translates into a cost of about 76,000 yuan.

[0051] The obtained ceramic membrane con...

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Abstract

The invention provides a method for removing protein from acarbose plate frame filtrate, and belongs to the technical field of acarbose production. The method comprises the following steps that the acarbose plate frame filtrate is filtered through a ceramic membrane, and ceramic membrane filtrate is obtained; and the interception precision of the ceramic membrane is less than or equal to 50nm, and the filtering pressure is more than or equal to 0.3 MPa. After the acarbose plate frame filtrate is treated by the ceramic membrane, the protein in the acarbose plate frame filtrate is reduced, the yield of subsequent resin adsorption acarbose is improved, the acid-base amount and the water consumption amount of resin regeneration are reduced, and the whole acarbose refining process is improved.

Description

technical field [0001] The invention relates to the technical field of acarbose production, in particular to a method for removing protein from acarbose plate and frame filtrate. Background technique [0002] Acarbose (Acarbose) is an α-glucosidase inhibitor, which is a complex oligosaccharide with a structure similar to oligosaccharides. This non-oligosaccharide "pseudo-oligosaccharide" can be found in the brush border of upper small intestine cells. It competes with oligosaccharides to reversibly combine with α-glucosidase, inhibits the activity of various α-glucosidases such as maltase, isomaltase, glucoamylase and sucrase, and decomposes starch into oligosaccharides such as maltose ( disaccharides), maltotriose and dextrin (oligosaccharides), which slow down the rate of decomposition of glucose, and slow down the rate of decomposition of sucrose into glucose and fructose, thus slowing down the absorption of glucose in the intestinal tract, thereby alleviating postprandia...

Claims

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Application Information

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IPC IPC(8): C07H1/06C07H15/203
CPCC07H1/06C07H15/203
Inventor 康辉董海峰林雄水郑贤坤
Owner 同舟纵横(厦门)流体技术有限公司