Preparation method of nano-particle rapamycin-loaded drug coating balloon

A nanoparticle and rapamycin technology, applied in coatings, catheters, etc., can solve the problems of sudden drug release and unstable release behavior, and achieve constant drug release in vitro, small particle size, and overcome negative effects Effect

Inactive Publication Date: 2021-12-21
孟繁宇
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, one of the difficulties in the preparation is the sudden release phenomenon and unstable release behavior of the drug

Method used

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Embodiment Construction

[0013] The technical solutions of the present invention will be further described in detail below in conjunction with specific embodiments.

[0014] Compared with organic polymer nanocarriers, inorganic nanoparticles have the advantages of good size and shape controllability and large specific surface area. At the same time, their unique optical, electrical and magnetic properties endow them with potential imaging development, targeted delivery and synergistic drug therapy. Therefore, in recent years, reports on inorganic nanomaterials as carriers of chemical drugs, DNA, and proteins have gradually increased. Among them, the development of hollow mesoporous silica nanoparticles (mesoporous silica nanoparticles) as a drug delivery system is very rapid. Mesoporous materials have a larger specific surface area than macroporous materials, and their pore diameters are also larger than microporous materials. Therefore, mesoporous materials have a wide range of applications in the fi...

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Abstract

The invention discloses a preparation method of a nano-particle rapamycin-loaded drug coating balloon, and belongs to the technical field of drug manufacturing. The surface of the balloon is coated with hollow mesoporous silica nano-particles (MSNs) loaded with Rapamycin (RPM) through polylactic acid-polyglycolic acid (PLGA). The polylactic acid-polyglycolic acid mixes the mesoporous silica nano-particles loaded with rapamycin into the surface of the balloon, the surface of the balloon is coated with the polylactic acid-polyglycolic acid, nano-particles are bridged to prepare the nano-particle rapamycin-loaded drug coating balloon which is excellent in histocompatibility, biodegradable, high in encapsulation efficiency, stable in drug loading capacity control, small in particle size and constant in-vitro drug release, the effective action concentration of the drug can be reached and maintained in local tissue under the condition that blood flow is affected as little as possible, the negative influence of a drug loading matrix on vascular repair can be overcome, and the anti-endometrial hyperplasia and anti-restenosis effects of rapamycin are improved. The inorganic nano-particles can be compounded with an up-conversion rare earth luminescent fluorescent agent, 4f electrons of a rare earth inner shell layer can emit light under laser irradiation, and therefore the nano-particle rapamycin-loaded drug coating balloon is used for simulating in-vitro conveying and expansion of the balloon in plasma and monitoring the concentration of the nano-particles left in the plasma and used for detecting the drug loading stability of the balloon in the early stage.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical manufacturing, in particular to a method for preparing a nanoparticle-loaded rapamycin drug-coated balloon. Background technique [0002] Most of the drug balloons currently available on the market are paclitaxel, and several studies have shown that rapamycin has a better anti-proliferation effect on coronary artery intima. The rapamycin is loaded on the hollow mesoporous silica nanoparticles, and the nanoparticles are alcoholized and wrapped on the ordinary balloon by polylactic acid-polyglycolic acid (PLGA). Nanoparticles of rapamycin are released on the vascular endothelium. Through the permeability and sustained release of nanoparticles, the loaded drugs are released sequentially to prolong the time of drug action, which can improve the anti-arterial intimal hyperplasia and anti-regeneration effects of rapamycin. Stenotic effect. [0003] Biodegradable materials are research hotspots ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/10A61L29/14A61L29/16
CPCA61L29/085A61L29/08A61L29/106A61L29/16A61L29/148A61L2300/216A61L2300/416A61L2300/606A61L2300/602C08L67/04
Inventor 孟繁宇
Owner 孟繁宇
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