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Novel coating medical porous zinc material and preparation method thereof

A coating and a new type of technology, applied in the field of biomedical metal material design and preparation, can solve the problems of difficult to prepare medical porous zinc, poor pore connectivity, low porosity, etc., and achieve improved biocompatibility, high porosity, The effect of reducing the risk of necrosis

Pending Publication Date: 2022-01-04
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods generally have problems such as poor pore connectivity and low porosity, and it is difficult to prepare medical porous zinc with high pore structure requirements.

Method used

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  • Novel coating medical porous zinc material and preparation method thereof
  • Novel coating medical porous zinc material and preparation method thereof
  • Novel coating medical porous zinc material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Step 1, template preprocessing;

[0075] Step 11, sample preparation;

[0076] Cut the 50PPI polyurethane sponge to 50mm in length and 50mm in width to become the first sample;

[0077] Step 12, prepare chemical degreasing liquid;

[0078] The NaOH needed to prepare 1L of chemical degreasing solution is 35g, NaOH 2 CO is 25g, Na 3 PO 4 10g, OP emulsifier 0.5ml and the balance of deionized water.

[0079] The pH value of the degreasing solution is kept between 10 and 12.

[0080] Step 13, the degreasing treatment of organic solvent;

[0081] Immerse the first sample in absolute ethanol and repeatedly extrude and stir for 60 s to degrease the organic solvent, rinse it with distilled water for 5 minutes after taking it out, and obtain the second sample;

[0082] Step 14, chemical degreasing treatment;

[0083] Immerse the second sample in the chemical degreasing solution prepared in step 12, repeatedly squeeze and stir for 5 minutes to carry out chemical degreasing...

Embodiment 2

[0135] The difference between embodiment 2 and embodiment 1 is:

[0136] Step 1, template preprocessing;

[0137] The aperture of the polyurethane sponge selected in step 11 is 40PPI;

[0138] Step 4, electrodepositing zinc layer;

[0139] The temperature of the plating solution in step 42 is 30°C, and the deposition time is 1h;

[0140] Step five, sintering treatment;

[0141] The sintering time in step five is 1h.

[0142] Step six, coating loading;

[0143] Step 61, preparing a reaction solution;

[0144] The concentration of the reaction solution was 3 mmol of solute per 70 mL of solvent.

[0145] The solutes were 640 mg of magnesium nitrate hexahydrate and 160 mg of DHTA.

[0146] The solvent is 60 mL of DMF, respectively adding 4 mL of deionized water and 4 mL of absolute ethanol.

[0147] Step 62, hydrothermal reaction;

[0148] Hang the ninth sample vertically on the polytetrafluoroethylene lining of the hydrothermal kettle, add the reaction solution, put the ...

Embodiment 3

[0153] The difference between embodiment 3 and embodiment 1 is:

[0154] Step 1, template preprocessing;

[0155] The aperture of the polyurethane sponge selected in step 11 is 60PPI;

[0156] Step 4, electrodepositing zinc layer;

[0157] The temperature of the plating solution in step 42 is 40°C, and the deposition time is 1h;

[0158] Step five, sintering treatment;

[0159] The sintering heat preservation time in step five is 2h.

[0160] Step six, coating loading;

[0161] Step 61, preparing a reaction solution;

[0162] The concentration of the reaction solution was 3 mmol of solute per 70 mL of solvent.

[0163] The solutes were 638 mg of magnesium nitrate hexahydrate, 2 mg of copper nitrate hexahydrate and 160 mg of DHTA.

[0164] The solvent is 60 mL of DMF, respectively adding 4 mL of deionized water and 4 mL of absolute ethanol.

[0165] performance analysis

[0166] The porous zinc material obtained by the method of Example 3 has three-dimensionally connec...

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Abstract

The invention discloses a novel coating medical porous zinc material and a preparation method thereof. The preparation method mainly comprises the following steps of sequentially carrying out degreasing, coarsening film removal and conductive treatment on a porous template, then taking the porous template as a cathode and a pure zinc plate as an anode, switching on a direct current power supply, carrying out constant current electrodeposition in a zinc sulfate salt electroplating solution, uniformly depositing a zinc layer with a certain thickness on the surface of the template, putting the template into a vacuum resistance furnace for sintering treatment to remove the template, carrying out hydrothermal reaction on porous zinc obtained by sintering treatment in a hydrothermal kettle of a coating reaction solution, and loading a uniform coating on the surface of the porous zinc. The porous zinc prepared by the preparation method disclosed by the invention is uniform in pore diameter and communicated with one another, has the porosity of 95 percent or above, is good in biocompatibility, is suitable for the field of tissue engineering scaffolds such as bone defect filling and repairing, and has a wide application prospect.

Description

technical field [0001] The invention relates to a novel coated medical porous zinc material and a preparation method thereof. A porous zinc material with uniform pore size and high porosity is obtained by electrodepositing a pure zinc coating on the surface of a polyurethane sponge, and a Mg-based MOFs coating is loaded on the surface. The structure of this material is similar to that of cancellous bone, the pores are interconnected and the porosity is high, which is conducive to the formation of capillaries inside, providing various nutrients for bone regeneration, and has good biocompatibility, which can induce bone regeneration. The technical field of design and preparation of biomedical metal materials. Background technique [0002] Porous metal material, also known as metal foam, is a multifunctional material with excellent performance. It has been widely used in automobiles, environmental protection, aerospace and other fields, and it also shows great application prosp...

Claims

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Application Information

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IPC IPC(8): C25D5/54C25D3/22C25D5/00C25D5/50C25D21/10C25D21/12C23C26/00A61L27/56A61L27/54A61L27/50A61L27/30A61L27/28A61L27/04
CPCC25D5/54C25D3/22C25D5/00C25D21/10C25D5/623C25D5/50C23C26/00C25D21/12A61L27/56A61L27/50A61L27/047A61L27/306A61L27/28A61L27/54A61L2430/02A61L2300/102A61L2300/404
Inventor 顾雪楠王一凡汤红艳陈凯樊瑜波
Owner BEIHANG UNIV
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