Method for adjusting polarization state of macrophage

A macrophage, polarization state technology, applied in the field of biomedicine, can solve the problem of few macrophages, and achieve the effect of promoting function
CN113897337AInactive Publication Date: 2022-01-07SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
3 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
Publication Date
2022-01-07
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to the technical field of biological medicines and particularly discloses a method for adjusting a polarization state of a macrophage. The method comprises the step of adopting an over-expressed HIMF gene to infect the macrophage or adopting specific siRNA to knock down or integrally knock out an HIMF gene in the macrophage. Through the mode, the macrophage is infected by adopting the over-expressed HIMF gene or the HIMF gene in the macrophage is knocked down or integrally knocked out by adopting the specific siRNA, and functions of macrophages of different polarization types are influenced, so that the occurrence and development of inflammations are inhibited, and the occurrence of myocardial infarction is delayed.
Need to check novelty before this filing date? Find Prior Art

Description

Technical field

[0001] The present application relates to a biomedical field, and in particular, a method involving a state of regulating macrophages. Background technique

[0002] Macrophages are polarized by bone marrow progenitor cells into monocytes into blood, migrate to polarization of the tissue. The macrophages are divided into a classic (M1) and alternative (M2) depending on the difference in activation and function. Under bacterial toxin LPS or TH1 cytokines (TNFα, IFNγ), macrophages are activated into M1, expression, and release related markers gene and active oxygen, with kill pathogens, remove necrotic tissue and promote inflammation. The effect of the reaction occurs; with the induction of TH2 cytokines (IL-4, IL-13), macrophages are activated as M2 type, express anti-inflammatory factors (such as TGFβ, IL-10), with Formulating inflammation, promoting the role of tissue growth and repair.

[0003] The study found that two different polarized macrophages have importa...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More