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Medical adhesive for lung trauma repair and use method thereof

A wound repair and adhesive technology, applied in surgical adhesives, applications, medical science, etc., can solve problems such as difficult to achieve lung wound closure, low adhesive strength, secondary damage, etc., to achieve comfortable and convenient implementation, Good biocompatibility effect

Pending Publication Date: 2022-01-21
广州迅合医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The suture causes secondary damage to the tissue and it is difficult to seal the lung wound, and there may be a risk of opening the suture during breathing
The existing medical adhesives that can be used for visceral bonding mainly include fibrin glue and PEG-based ester adhesives, which have low adhesive strength and "pneumothorax" phenomenon caused by insufficient closure of lung wounds in clinical practice

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The first step, the preparation of aliphatic polyurethane prepolymer: add 4.76gLDI (95%, 20mmol) and 10.1gPEG1000 (99.9%, 10mmol) accordingly in heating, stirring, closed container, react for a certain period of time so that -OH is completely Consumption; then add 0.473g glycerol (99.9%, 5.13mmol) to react for a certain period of time so that -OH is completely consumed, filter impurities to obtain aliphatic polyurethane prepolymer (component A), and add trace phosphoric acid therein as a stabilizer.

[0019] The second step, the preparation of aliphatic modified secondary amine curing agent: add 0.63g 1,5-pentanediamine (98%, 6mmol) and 1.74g diethyl maleate (99%, 10mmol) successively in a stirring and closed container ), and then add 0.1% mass fraction of ammonium cerium nitrate therein, after reacting for 24 hours, the product is further purified by column chromatography to obtain the aliphatic modified secondary amine curing agent (component B).

[0020] When in use,...

Embodiment 2

[0022] The first step, the preparation of aliphatic polyurethane prepolymer: add 9.52gLDI (95%, 40mmol) and 20.2gPEG2000 (99.9%, 10mmol) accordingly in heating, stirring, closed container, react for a certain period of time so that -OH is completely Consumption; add 0.62g glycerol (99.9%, 6.67mmol) subsequently and react for a certain period of time so that -OH is completely consumed, filter impurities to obtain aliphatic polyurethane prepolymer (component A), add a small amount of benzoyl chloride therein as a stabilizer agent.

[0023] The second step, preparation of aliphatic modified secondary amine curing agent: add 0.69g1,6-hexamethylenediamine (99%, 6mmol) and 0.85g methyl acrylate (99%, 10mmol) successively in stirring, closed container, then Add 0.1% yttrium nitrate by mass fraction therein, react for 24 hours, and further purify the product by column chromatography to obtain aliphatic modified secondary amine curing agent (component B).

[0024] When in use, mix com...

Embodiment 3

[0026] The first step, the preparation of aliphatic polyurethane prepolymer: add 4.76gLDI (95%, 20mmol) and 15.2gPEG1500 (99.9%, 10mmol) accordingly in heating, stirring, closed container, react for a certain period of time so that -OH is completely Consumption; then add 0.475g glucose (99.9%, 2.67mmol) to react for a certain period of time so that -OH is completely consumed, filter impurities to obtain aliphatic polyurethane prepolymer (A component), and add trace phosphoric acid therein as a stabilizer.

[0027] The second step, preparation of aliphatic modified secondary amine curing agent: add 0.89gN'N-bis(3-aminopropyl)methylamine (98%, 6mmol) and 1.74g maleic acid di Ethyl ester (99%, 10mmol), then add the ceric ammonium nitrate of 0.1% mass fraction thereinto, after reacting for 24 hours, the product is further purified by column chromatography separation to obtain aliphatic modified secondary amine curing agent (B component) .

[0028] When in use, mix components A an...

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Abstract

The invention discloses a medical adhesive for lung trauma repair and a use method thereof. The medical adhesive comprises a component A and a component B, the component A is an aliphatic polyurethane prepolymer based on long-chain polyethylene glycol and micromolecular polyol, and the component B is an aliphatic modified secondary amine curing agent; the component A is prepared by the following steps: reacting long-chain polyethylene glycol, namely long-chain PEG, with L-lysine diisocyanate, namely LDI, to obtain an intermediate, and adding a micromolecular polyol chain extender to obtain an aliphatic polyurethane prepolymer; and and the component B is prepared by the following steps: reacting aliphatic diprimary amine with an alpha, beta-unsaturated carbonyl compound according to a functional group molar ratio of-NH2:-C=C at 1.2:1 under a catalysis of a transition metal with a mass percentage of 0.1%, and obtaining an aliphatic modified secondary amine curing agent through a column chromatography separation. The prepared medical adhesive is free of biotoxicity, has good flexibility, equivalence to a lung elasticity modulus and a high adhesive strength and is suitable for blocking and repairing wounds after a clinical local lung operation.

Description

technical field [0001] The invention relates to the technical field of three types of medical devices, in particular to a medical adhesive for lung trauma repair and its application method. Background technique [0002] Existing means of repairing lung trauma: surgical suture, PEG medical glue. The sutures cause secondary damage to the tissue and it is difficult to seal the lung wound, and there may be a risk of opening the sutures during breathing. Existing medical adhesives that can be used for visceral adhesion mainly include fibrin glue and PEG-based ester adhesives, which have low adhesive strength, and there is a phenomenon of "pneumothorax" caused by insufficient closure of lung wounds in clinical practice. Contents of the invention [0003] The purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art, and propose a medical adhesive for lung trauma repair and its application method. The medical adhesive has good biosafety, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/00
CPCA61L24/046A61L24/001C08L75/08
Inventor 施雪涛宣承楷张照国廖佳宁
Owner 广州迅合医疗科技有限公司
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