Application of dodecylmethylaminoethyl methacrylate (DMAMA) in preparation of medicine for inhibiting helicobacter pylori in oral cavity and stomach

A technology of Helicobacter pylori and tertiary amines, applied in the field of anti-Helicobacter pylori treatment, can solve problems such as lack of effective anti-Helicobacter pylori infection, reduce the probability of stomach and systemic diseases, reduce the risk of infection, and have strong anti-Helicobacter pylori resistance. Effects of Features

Active Publication Date: 2022-01-28
SICHUAN UNIV
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  • Abstract
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Problems solved by technology

Lack of research and development of new drugs effective against Helicobacter pylori infection

Method used

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  • Application of dodecylmethylaminoethyl methacrylate (DMAMA) in preparation of medicine for inhibiting helicobacter pylori in oral cavity and stomach
  • Application of dodecylmethylaminoethyl methacrylate (DMAMA) in preparation of medicine for inhibiting helicobacter pylori in oral cavity and stomach
  • Application of dodecylmethylaminoethyl methacrylate (DMAMA) in preparation of medicine for inhibiting helicobacter pylori in oral cavity and stomach

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Embodiment Construction

[0048] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0049] Aiming at the problems existing in the prior art, the present invention provides a novel material preparation method against Helicobacter pylori. The present invention will be described in detail below with reference to the accompanying drawings.

[0050] Those of ordinary skill in the industry can also use other steps to implement the novel material preparation method against Helicobacter pylori provided by the present invention, figure 1 The preparation method of the novel material against Helicobacter pylori provided by the present invention is only a specific example.

[0051] The invention provides a use of a n...

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Abstract

The invention belongs to the technical field of anti-helicobacter pylori treatment, and discloses application of DMAMA in preparation of a medicine for inhibiting helicobacter pylori in the oral cavity and the stomach. According to the invention, the minimum inhibitory concentration and the minimum bactericidal concentration of the medicine are determined through flat plate and bacterial suspension culture; the variation of bacterial quantities under the action of the medicine and the influence of the medicine on a bacterial toxicity level are determined; and cell safety detection is conducted. Aiming at the conditions that local drugs for effectively treating helicobacter pylori infection are lacked under existing conditions and the drug resistance rate of helicobacter pylori antibiotics is increased year by year, the pH sensitive characteristic of the DMAEM is combined for the first time, the DMAEM acts on the helicobacter pylori, and it is found that the DMAEM has a remarkable bactericidal effect on the helicobacter pylori and can effectively prevent and treat the helicobacter pylori infection. Meanwhile, the detection of the DMAEM has good biological safety. The DMAEM has relatively strong helicobacter pylori growth and proliferation resisting effects, so the adverse use of antibiotics is reduced, and the problems of antibiotic resistance and host flora disorder caused by antibiotic resistance are reduced.

Description

technical field [0001] The invention belongs to the technical field of anti-helicobacter pylori treatment, and in particular relates to the use of a tertiary amine monomer in the preparation of medicines for inhibiting oral and gastric helicobacter pylori. Background technique [0002] At present, Helicobacter pylori is a common infectious bacteria in humans, and its infection has become a global health problem. More than half of the people in the world are infected with Helicobacter pylori, and the infection rate in my country is 40-60%. Helicobacter pylori is a risk factor for many diseases such as chronic gastritis, gastric ulcer, gastric adenocarcinoma, and even mucosa-associated lymphoid tissue lymphoma. In 1994, the International Agency for Research on Cancer (IARC) of the World Health Organization listed Helicobacter pylori as a human I carcinogen. 67% to 80% of gastric ulcers and 95% of duodenal ulcers are caused by Helicobacter pylori, and about 39% of gastric canc...

Claims

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Application Information

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IPC IPC(8): A61K31/5375A61P31/04A61P1/02A61P1/04A61P35/00C12Q1/18C12Q1/06C12Q1/02C12Q1/689C12R1/01
CPCA61K31/5375A61P31/04A61P1/02A61P1/04A61P35/00C12Q1/18C12Q1/06C12Q1/689G01N33/5014G01N2333/195Y02A50/30
Inventor 程磊陈曦任彪周学东
Owner SICHUAN UNIV
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