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Controllable anti-inflammatory drug slow-release system based on nanofiber material

An anti-inflammatory drug and nanofiber technology, applied in the direction of anti-inflammatory agent, drug combination, fibrochemical characteristics, etc., can solve the problems of complex process, low efficiency of nanoparticles and vesicles, and low drug release efficiency, and achieve simple process, The effect of long drug-loaded release time and uniform release rate

Pending Publication Date: 2022-02-08
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The unsolved problems of polymer drug-loaded delivery systems include: low efficiency of preparing nanoparticles and vesicles, complicated process, low drug release efficiency, etc.
However, it requires long-term stable and slow release in order to achieve a more ideal clinical effect

Method used

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  • Controllable anti-inflammatory drug slow-release system based on nanofiber material
  • Controllable anti-inflammatory drug slow-release system based on nanofiber material
  • Controllable anti-inflammatory drug slow-release system based on nanofiber material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Polyurethane (PU) and methylprednisolone (MP) were used as raw materials for electrospinning, and N,N-dimethylformamide (DMF) and tetrahydrofuran (THF) were used as solvents.

[0046] Components in parts by weight:

[0047]

[0048] Wherein, the solvent is N,N-dimethylformamide (DMF) and tetrahydrofuran (THF), and the ratio is 1:1.

[0049] Weigh DMF / THF (1 / 1) = 4.725 g with an electronic balance, and place it in a clean glass stirring bottle as a solvent. Then weigh 0.5 g of PU and put it into a glass stirring bottle. Stir at 60°C for 3 hours in a digital display temperature-controlled heating stirrer to completely dissolve the PU, and finally obtain a uniform and stable spinning solution. Then electrospinning was carried out to prepare MP-loaded nanofibrous materials. Electrospinning parameters are as follows: temperature is 40.0°C, humidity is 23.1%, spinning distance is 11cm, liquid supply speed is 2mL / h, slide table speed is 15mm / s, drum speed is 300rad / min, ...

Embodiment 2

[0053] Polyurethane (PU), silver nitrate (AgNO 3 ), methylprednisolone (MP) was used as the raw material for electrospinning, and N,N-dimethylformamide (DMF) and tetrahydrofuran (THF) were used as solvents. Components in parts by weight:

[0054]

[0055] Wherein, the solvent is N,N-dimethylformamide (DMF) and tetrahydrofuran (THF), and the ratio is 1:1. Weigh DMF / THF (1 / 1)=4.7g with an electronic balance, and place it in a clean glass stirring bottle as a solvent. Then weigh 0.05g of AgNO 3 and 0.5g of PU into a glass stirring bottle. Stir at 60°C for 3 hours in a digital display temperature-controlled heating stirrer to completely dissolve the PU, and finally obtain a uniform and stable spinning solution. Electrospinning was performed to prepare MP-loaded nanofibrous materials. Electrospinning parameters are as follows: temperature is 40.0°C, humidity is 23.1%, spinning distance is 11cm, liquid supply speed is 2mL / h, slide table speed is 15mm / s, drum speed is 300rad / ...

Embodiment 3

[0059] Polyurethane (PU), silver nitrate (AgNO 3 ), graphene oxide (GO), methylprednisolone (MP) as raw materials for electrospinning, and N,N-dimethylformamide (DMF) and tetrahydrofuran (THF) as solvents. Components in parts by weight:

[0060]

[0061]

[0062] Wherein, the solvent is N,N-dimethylformamide (DMF) and tetrahydrofuran (THF), and the ratio is 1:1. Weigh DMF / THF (1 / 1)=4.6895g with an electronic balance, and place it in a clean glass stirring bottle as a solvent. Then weigh 0.05g of AgNO 3 and 0.003 g of GO in a glass stirring bottle. Then the glass bottle was placed in an ultrasonic cleaner and ultrasonicated for 60 min to completely disperse GO in the solution. Then 0.5 g of PU was added, and the total mass of the spinning solution was 10 g. Stir at 60°C for 3 hours in a digital display temperature-controlled heating stirrer to completely dissolve the PU, and finally obtain a uniform and stable spinning solution. Nanofibrous carrier materials were pr...

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Abstract

The invention discloses an controllable anti-inflammatory drug slow-release system based on a nanofiber material. A nanofiber material with electricity-strain dual stimulation responsiveness is prepared by taking polyurethane (PU) as a solute and N,N-dimethylformamide (DMF) and tetrahydrofuran (THF) as solvents, and then adding an electric conductor and an anti-inflammatory drug. The nanofiber carrier material has good conductivity and elastic deformation capability, namely, has electricity-strain dual stimulation responsiveness. After the material is used as a drug carrier, the release time of a loaded drug is prolonged, a release speed becomes more uniform, and the release efficiency of the loaded drug can reach 98.89%. In conclusion, the material can generate stable and fluctuating electrical stimulation signals, and a wider and more reliable experimental basis is provided for stimulation treatment. Moreover, a preparation method is simple in process and high in operability, and the prepared nanofiber material has excellent conductivity, mechanical property, wet stability and biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of material preparation, and relates to a controllable slow-release system of anti-inflammatory drugs based on a nanofiber material, in particular to a long-acting controllable slow-release nanofiber carrier material and a preparation method thereof with double electrical-strain stimulation response. Background technique [0002] 1. Commonly used biological materials loaded with drugs: [0003] With the development of material technology, more and more biomaterials are used in drug delivery system (DDS), so as to improve the targeting and water solubility of drugs, reduce the side effects of drugs, improve the therapeutic effect of drugs, and ultimately reduce the number of patients. pain of. Polymer materials are usually used as carrier materials for drug-loaded delivery systems, and can be divided into biodegradable materials and non-degradable materials according to their degradation properties. Biodegr...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/04A61K47/02A61K31/573A61P29/00D01F6/94D01F1/10D01F1/02D01F1/09
CPCA61K47/34A61K47/02A61K31/573A61P29/00D01F6/94D01F1/10D01F1/02D01F1/09
Inventor 冯建永郑沈怡杨晓园
Owner ZHEJIANG SCI-TECH UNIV