Gold porphyrin MOF nanosheet with ultrasonic stimulation response as well as preparation method and application of gold porphyrin MOF nanosheet

Abstract

The invention discloses a gold porphyrin MOF nanosheet with ultrasonic stimulation response as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing a DMF / ethanol solution of tetrapyridine-based gold porphyrin; (2) preparing a DMF / ethanol solution of copper nitrate, benzoic acid and PVP; and (3) adding the solution in the step (2) into the system in the step (1) under a stirring condition, ultrasonically conducting mixing uniformly, conducting heating at high temperature, and centrifugally conducting separating to obtain a precipitate, namely the gold porphyrin MOF nanosheet. According to the nanosheet, due to stimulation response of low-power ultrasound, the gold porphyrin is slowly released at a tumor part to play a role in chemotherapy; and meanwhile, the node Cu<2+> effectively consumes reduced glutathione (GSH) overexpressed in cells to generate hydroxyl free radicals (.OH) to induce tumor cell apoptosis, the chemotherapy effect is remarkably enhanced, and the problem of drug resistance is effectively solved while the dosage of chemotherapy drugs is reduced. The method is simple and efficient and can be used for large-scale preparation.

Description

technical field [0001] The invention belongs to the technical fields of material chemistry and bionano medicine, and in particular relates to a gold porphyrin MOF nanosheet with ultrasonic stimulus response, its preparation method and application. Background technique [0002] Cancer has become one of the major public health problems that threaten human life and health. Basic and clinical research on effective treatment of tumors is still very urgent. At present, many treatment methods such as surgical resection, chemotherapy, and radiotherapy have certain side effects. For example, surgical resection also removes part of the normal tissue while removing the tumor, and it is basically difficult to cure some gliomas; the radioactive elements used in radiotherapy cause large radiation to biological tissues, which seriously damages the health of the organism; Chemotherapy drugs are generally insoluble in water, have poor biocompatibility, short circulation time in the body, a...

AI Technical Summary

Problems solved by technology

For example, surgical resection also removes part of the normal tissue while removing the tumor, and it is basically difficult to cure some gliomas; the radioactive elements used in radiotherapy cause large radiation to biological tissues, which seriously damages the health of the organism; Chemotherapy drugs are generally insoluble in water, have poor biocompatibility, short circulation time in the body, and do not have the ability to specifically recognize tumor cells, and then kill tumor cells and normal tissues at the same time. The treatment cycle is long and drug resistance is prone to occur. Treatment effect is not significant

Images