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Bionic three-dimensional hierarchical micro-nano structure integrated micro device and preparation and application thereof

A technology of micro-nano structures and micro-devices, applied in the field of bionic structures, can solve few problems, and achieve the effects of easy modification, improved roughness, and simple manufacturing process and method.

Active Publication Date: 2022-02-08
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, many studies have reported that nanostructured substrates can enhance the capture efficiency of CTCs, but there are few studies on the construction of three-dimensional micro-nanostructured microdevices to enhance the capture and efficient release of CTCs in a simple way.

Method used

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  • Bionic three-dimensional hierarchical micro-nano structure integrated micro device and preparation and application thereof
  • Bionic three-dimensional hierarchical micro-nano structure integrated micro device and preparation and application thereof
  • Bionic three-dimensional hierarchical micro-nano structure integrated micro device and preparation and application thereof

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Embodiment 1

[0048] The fabrication method and application of the microdevice with three-dimensional micro-nano structure (hierarchical ZnO micro-nano structure) prepared by the rose petal template method will be described in detail below by way of examples.

[0049] Figure 4It is a schematic flowchart of a method for preparing a micro-device with a three-dimensional hierarchical micro-nano structure by using the petal template method of the present invention. Among them, 1 is a rose petal, 2 is a PDMS prepolymer, 3 is a PDMS template derived from a rose petal, 4 is ZnO, 5 is a ZnO-modified PDMS template, and 6 is a ZnO-modified PDMS template cut into a cylinder with a diameter of 1.1 cm 7 is the EpCAM aptamer, 8 is the EpCAM aptamer modified PDMS template, 9 is the EpCAM positive cancer cell, and 10 is the EpCAM positive cancer cell captured on the EpCAM aptamer modified PDMS template.

[0050] The specific steps are as follows:

[0051] (1) Stick the rose petals on the petri dish with...

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Abstract

The invention relates to a bionic three-dimensional hierarchical micro-nano structure integrated micro device and preparation and application thereof, and belongs to the technical field of bionic structures. A three-dimensional micro-nano structure on an inner wall of a rose petal is copied to a surface of the polymer to obtain a polymer template containing the three-dimensional micro-nano structure of the rose petal; hydrophilic treatment is carried out on the polymer template, then oxide nanoparticles grow on the surface of the three-dimensional micro-nano structure in situ, the oxide nanoparticles are used for enhancing the surface roughness of the three-dimensional micro-nano structure, and the micro device with the three-dimensional hierarchical micro-nano structure is obtained and used for high-sensitivity capture of circulating tumor cells (CTCs). The method is simple in processing and manufacturing process and low in cost. Different biomolecules, such as DNA and protein, are coupled on the surfaces of the nanoparticles, so that the bionic three-dimensional hierarchical micro-nano structure can be widely applied to separation and purification of pathogens.

Description

technical field [0001] The invention belongs to the technical field of bionic structures, and more specifically relates to a bionic three-dimensional hierarchical micro-nano structure integrated micro device and its preparation and application. Background technique [0002] Bionics is a science that studies the structure and properties of biological systems to provide new design ideas and working principles for engineering technology. Biomimetic technology studies the functional principles and mechanisms of various biological systems as biological models, and finally realizes new technical design and manufactures better new instruments and machinery. [0003] Meanwhile, efficient capture and release of circulating tumor cells (CTCs) is another research hotspot for CTC-associated cancer diagnosis and subsequent analysis. It is a great challenge to isolate and enrich CTCs with extremely low content from complex peripheral blood samples. Therefore, it is urgent to develop a fa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/40C12M1/00C12N5/09
CPCG01N1/40G01N1/405C12M47/04C12N5/0693C12N2509/00
Inventor 徐丽余旭王乐
Owner HUAZHONG UNIV OF SCI & TECH
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