Externally-applied glucosamine chondroitin nano-preparation and preparation method thereof

A nano-formulation, chondroitin technology, applied in nano-technology, nano-technology, nano-drugs and other directions, can solve the problems of active ingredients staying on the surface of the stratum corneum of the skin, unable to reach the depths of joints, poor transdermal absorption, etc., to save production Cost, less usage, pain relief effect

Pending Publication Date: 2022-02-11
杭州拾珍医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to solve the problem that the transdermal absorption of glucosamine chondroitin products in the prior art is poor, the active ingredients can only stay on the surface of the stratum corneum of the skin, and cannot reach the deep joints, etc. The glucosamine chondroitin product has smaller particle size, high skin penetration rate, less active ingredient usage, and saves production costs. Glucosamine and chondroitin can quickly penetrate into joints, lubricate joints, repair cartilage, and quickly relieve pain. Glucosamine chondroitin nano preparation and preparation method thereof

Method used

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preparation example Construction

[0018] A glucosamine chondroitin nano-preparation for external use and a preparation method thereof, comprising nanoliposomes and an inner material; the inner material includes the following components in mass percentages: glycerin 4-6%, propylene glycol 3-6%, N-acetyl-D-glucosamine 5-12%, humectant 2-4%, penetration enhancer 8-10%, shark bone chondroitin sulfate 2-8%, bovine osteochondroitin 1-3%, lipid material 8-12%, stearyl alcohol 2-6%, cetyl alcohol 2-6%, mineral oil 8-10%, silicone oil 2-4%, emulsifier 2-4%, preservative 1.2-1.6%, the rest is Deionized water.

[0019] As a preferred technical solution, the humectant is one or more mixtures of glycerin, propylene glycol, butylene glycol, and the like.

[0020] As a preferred technical solution, the described penetration enhancer is one or more mixtures of menthol, borneol, peppermint oil and the like.

[0021] As a preferred technical solution, the lipid material is a mixture of hydrogenated lecithin and egg yolk lecit...

Embodiment 1

[0026] Embodiment 1, the present invention relates to an externally applied glucosamine chondroitin nano-preparation for relieving pain and inflammation of osteoarthritis, repairing cartilage tissue, including nanoliposomes and inner materials; the inner materials include the following mass percentages The components: glycerin 4%, propylene glycol 3%, N-acetyl-D-glucosamine 5%, humectant 2%, penetration enhancer 8%, shark bone chondroitin sulfate 2%, bovine osteochondroitin 1%, Lipid material 8%, stearyl alcohol 2%, cetyl alcohol 2%, mineral oil 8%, silicone oil 2%, emulsifier 2%, preservative 1.2%, deionized water 48.8%.

[0027] The present invention also relates to a preparation method for external application of glucosamine chondroitin nano preparations, comprising the following steps:

[0028] 1) Mix the lipid material, stearyl alcohol, cetyl alcohol, mineral oil, silicone oil, and emulsifier, heat to 75°C, stir and disperse to form an oil phase;

[0029] 2) Add glycerin...

Embodiment 2

[0032]Embodiment 2, the present invention relates to an externally applied glucosamine chondroitin nano-preparation for relieving pain and inflammation of osteoarthritis and repairing cartilage tissue, including nanoliposomes and inner material; the inner material includes the following mass percentages The components: glycerin 5%, propylene glycol 5%, N-acetyl-D-glucosamine 10%, humectant 4%, penetration enhancer 8%, shark bone chondroitin sulfate 3%, bovine osteochondroitin 1.5%, Lipid material 8%, stearyl alcohol 2%, cetyl alcohol 2%, mineral oil 8%, silicone oil 2%, emulsifier 2%, preservative 1.2%, deionized water 38.3%.

[0033] The present invention also relates to a preparation method for external application of glucosamine chondroitin nano preparations, comprising the following steps:

[0034] 1) Mix the lipid material, stearyl alcohol, cetyl alcohol, mineral oil, silicone oil, and emulsifier, heat to 75°C, stir and disperse to form an oil phase;

[0035] 2) Add glyc...

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Abstract

The invention discloses an externally-applied glucosamine chondroitin nano-preparation and a preparation method thereof. The externally-applied glucosamine chondroitin nano-preparation comprises a nano-liposome and an inner material, the inner material comprises the following components in percentage by mass: 4-6% of glycerol, 3-6% of propylene glycol, 5-12% of N-acetyl-D-glucosamine, 2-4% of a humectant, 8-10% of a penetration enhancer, 2-8% of shark bone chondroitin sulfate, 1-3% of bovine bone chondroitin, 8-12% of a lipid material, 2-6% of stearyl alcohol, 2-6% of cetyl alcohol, 8-10% of mineral oil, 2-4% of silicone oil, 2-4% of an emulsifier, 1.2-1.6% of a preservative and the balance of deionized water. The particle size is smaller, the transdermal rate is high, the usage amount of effective components is small, the production cost is saved, and glucosamine and chondroitin can rapidly permeate into joints to lubricate the joints, relieve osteoarthritis pain and inflammation and repair cartilage tissue.

Description

technical field [0001] The invention relates to a nano-glucosamine chondroitin preparation for external application and a preparation method thereof. Background technique [0002] Osteoarthritis is a degenerative disease of bones and joints, most of which are knee joints. Osteoarthritis is also one of the diseases with a high disability rate, and it is extremely harmful to society. Modern medicine has found that the most fundamental cause of bone and joint diseases is the wear and tear of articular cartilage and the loss of bone and joint synovial fluid, which has a lot to do with the lack of ammonia and chondroitin in the body. [0003] Glucosamine, whose chemical name is N-acetyl-D-glucosamine, is regarded by the medical community as the only substance that can fundamentally improve bone and joint diseases. Glucosamine has a very high affinity for articular cartilage and can penetrate into the cartilage matrix. Exogenous supplementation of glucosamine can not only stimul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61K31/7008A61K9/127A61P29/00B82Y5/00B82Y40/00
CPCA61K31/737A61K31/7008A61K9/127A61K9/0014A61K47/34A61P29/00B82Y5/00B82Y40/00A61K2300/00
Inventor 罗金凤王稹
Owner 杭州拾珍医疗器械有限公司
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