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Palladium-silver nanoparticles and application and preparation method thereof

A silver nanoparticle and nanoparticle technology, applied in the field of antibacterial, can solve the problems of limiting the potential application scenarios and action efficiency of artificial peroxidase, the inability to add hydrogen peroxide, and biological toxicity, so as to reduce the possibility of drug resistance, Stable and long-lasting antibacterial effect with low cost

Active Publication Date: 2022-02-22
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Higher concentrations of hydrogen peroxide are known to be cytotoxic by themselves, and additional hydrogen peroxide is likely to cause biotoxicity
In addition, if the target application scenario of artificial peroxidase is the subcutaneous location of the organism, then it will not be possible to apply hydrogen peroxide
In summary, the requirement of additional hydrogen peroxide limits the potential application scenarios and efficiency of artificial peroxidase in the field of antibacterial

Method used

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  • Palladium-silver nanoparticles and application and preparation method thereof
  • Palladium-silver nanoparticles and application and preparation method thereof
  • Palladium-silver nanoparticles and application and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] 1. Add hydrogen chloride solution and 100 mg polyvinylpyrrolidone to sodium bisulfide (0.04 mg) ethylene glycol solution (10 mL), mix well, add 99.67 mg of silver trifluoroacetate to obtain silver nanoparticles. Silver nanoparticles have a hexahedral structure. The size of the silver nanoparticles is around 50 nanometers.

[0073] 2. Mix 0.50 mg of silver nanoparticles with polyvinylpyrrolidone aqueous solution, heat (50° C.) and mix (10 minutes), add 0.14 to 2.82 mg of potassium chloropalladate to obtain palladium silver nanocages.

[0074] figure 1 Microstructure diagram of the palladium-silver nanocage artificial oxidase prepared for this example.

[0075] It can be seen that the size of the palladium-silver nanocage is about 70 nanometers.

[0076] The molar content of palladium in the palladium-silver nanocages is detected by ICP-MS to be 10%-60%.

Embodiment 2

[0078] 1. Add hydrogen chloride solution and 300 mg polyvinylpyrrolidone to sodium bisulfide (0.04 mg) ethylene glycol solution (30 mL), mix well, add 99.67 mg of silver trifluoroacetate to obtain silver nanoparticles. Silver nanoparticles have a hexahedral structure. The size of the silver nanoparticles is around 60 nanometers.

[0079] 2. Mix 0.50 mg of silver nanoparticles with polyvinylpyrrolidone aqueous solution, heat (100° C.) and mix (30 minutes), add 0.14 to 2.82 mg of potassium chloropalladate to obtain palladium silver nanocages.

[0080] After testing, the size of the palladium-silver nanocage is about 70 nanometers. The molar content of palladium in the palladium-silver nanocage is 10%-60%.

Embodiment 3

[0082] 1. Hydrogen chloride solution and 200mg polyvinylpyrrolidone were added to a diethylene glycol solution (10mL) of sodium sulfide (0.04mg), mixed evenly, and silver nitrate 99.67mg was added to obtain silver nanoparticles. Silver nanoparticles have a hexahedral structure. The size of the silver nanoparticles is around 60 nanometers.

[0083] 2. Mix 0.50 mg of silver nanoparticles with polyvinylpyrrolidone aqueous solution, heat (80° C.) and mix (20 minutes), add 0.14 to 2.82 mg of potassium chloropalladate to obtain palladium silver nanocages.

[0084] After testing, the size of the palladium-silver nanocage is about 70 nanometers. The molar content of palladium in the palladium-silver nano cage is 10%-60%.

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Abstract

The invention provides a palladium-silver nanoparticle which is a palladium-silver alloy material with a hollow hexahedron structure. Silver with a high proportion is doped into palladium metal, the prepared palladium-silver nanoparticle artificial oxidase is of a hollow structure, the distance between palladium atoms is changed, the antibacterial performance of the artificial oxidase is improved, and cost is reduced. As an antibacterial agent, the palladium-silver nanoparticles are safe and efficient, can catalyze molecular oxygen to generate reactive oxygen species without additional auxiliary conditions (such as light, heat and the like) or additional auxiliary substances (such as hydrogen peroxide and the like), are safe and non-toxic, have no obvious toxic or side effect on mammalian cells, and significantly reduce the possibility that bacteria generate drug resistance. In the process of catalyzing oxygen to generate active oxygen to achieve the antibacterial function, palladium and silver (including silver ions) are not released, loss does not exist, and the antibacterial effect is more stable and lasting.

Description

technical field [0001] The invention relates to the field of antibacterial technology, in particular to a palladium-silver nano particle and a preparation method and application thereof. Background technique [0002] The emergence and rapid spread of bacterial resistance to antibiotics is a serious threat to global public health security. Currently, 700,000 people die each year due to bacterial resistance worldwide; according to estimates from the World Health Organization, this number will reach 10 million by 2050. Compared with the increasingly serious bacterial resistance, the traditional antibiotic-based antibacterial means lags behind in its research and development speed, and the new antibiotics approved for marketing are showing a downward trend year by year regardless of the type or quantity of drugs. Therefore, research and development of new antibacterial methods are of great significance. [0003] At present, a variety of antibacterial agents have been reported ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K33/38A61K47/69A61P31/04B82Y5/00B82Y30/00B82Y40/00
CPCA61K33/24A61K33/38A61K47/6949A61P31/04B82Y5/00B82Y30/00B82Y40/00Y02A50/30
Inventor 阳丽华熊宇杰高峰邵天一李明
Owner UNIV OF SCI & TECH OF CHINA
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