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Preparation method of W/O/W type temperature-sensitive embolization agent

A temperature-sensitive embolic agent and temperature-sensitive technology, applied in surgical adhesives, medical science, tissue regeneration, etc., can solve the problems of decreased fluidity, impact on embolization effect, decreased gel strength, etc. The effect of weakening the embolization effect and improving the developing ability

Active Publication Date: 2022-03-01
THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the actual operation process, the development ability is often improved by increasing the amount of developer; however, too much developer will increase the viscosity of the gel, reduce fluidity, and at the same time cause the gel strength to decrease and become soft, affecting Embolism effect

Method used

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  • Preparation method of W/O/W type temperature-sensitive embolization agent
  • Preparation method of W/O/W type temperature-sensitive embolization agent
  • Preparation method of W/O/W type temperature-sensitive embolization agent

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preparation example Construction

[0029] The embodiment of the present invention provides a preparation method of a W / O / W type thermosensitive embolic agent, comprising the following steps:

[0030] a) Provide temperature-sensitive nanogel, which is a poly-N-isopropylacrylamide polymer with a three-dimensional network structure, and disperse the temperature-sensitive nanogel and the first aqueous developer in water to obtain an outer surface water box;

[0031] b) providing an oil phase in which an oily developer is dispersed;

[0032] c) providing an internal water phase, mixing the internal water phase and the oil phase, and performing the first emulsification to obtain a W / O emulsion;

[0033] d) The W / O emulsion is mixed with the external water phase, and the second emulsification is carried out under ice bath conditions, and the second emulsification is intermittent emulsification to obtain a W / O / W type thermosensitive embolism.

[0034] It can be understood that the above-mentioned a), b), c), and d) d...

Embodiment 1

[0080] Example 1 of the present invention prepared a temperature-sensitive embolic agent according to the formula in Table 1. The temperature-sensitive nanogel is MBA-crosslinked PNIP, and its specific preparation method includes the following steps:

[0081] (1) The temperature-sensitive nanogel is poly(N-isopropylacrylamide) cross-linked by N,N'-methylenebisacrylamide, and its preparation method is as follows:

[0082] Add 2.263g of N-isopropylacrylamide, 0.032g of sodium lauryl sulfate, and 0.032g of MBA into a 250ml three-necked bottle equipped with a reflux condenser and a gas guiding device, and stir with 170ml of ultrapure water under magnetic force Dissolve under low temperature, then pass high-purity nitrogen into the above reaction system for 30min, heat the reaction system to 70°C, add 0.095g of initiator potassium persulfate, and 2 In the atmosphere, react at 70±1°C for 4.5h to obtain a white turbid suspension, dialyze and purify the suspension in ultrapure water, ...

Embodiment 2

[0091] Example 2 of the present invention prepared a temperature-sensitive embolic agent according to the formula in Table 2. The temperature-sensitive nanogel is poly(NIP-co-AA) cross-linked with N,N'-methylenebisacrylamide. The preparation method comprises the following steps:

[0092] (1) The temperature-sensitive nanogel is poly(NIP-co-AA) cross-linked by N,N'-methylenebisacrylamide, and its preparation method is as follows:

[0093] Add 2.263g of N-isopropylacrylamide, 0.032g of sodium lauryl sulfate, and 0.032g of N,N'-methylenebisacrylamide into a 250ml three-necked flask equipped with a reflux condenser and a gas guiding device 170ml of ultrapure water was used to dissolve under magnetic stirring, and high-purity nitrogen was passed into the above reaction system for 30 minutes, the reaction system was heated to 70°C, 0.095g of initiator potassium persulfate was added, and 2 In the atmosphere, react at 70±1°C for 0.5h, then add 0.27g of acrylic acid, and continue to r...

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Abstract

The invention provides a preparation method of a W / O / W type temperature-sensitive embolization agent, which comprises the following steps: dispersing temperature-sensitive nanogel and a first water-based developer in water to obtain an outer water phase; mixing the internal water phase and the oil phase dispersed with the oily developer, and performing primary emulsification to obtain W / O emulsion; and mixing the W / O emulsion with an external water phase, and carrying out secondary emulsification under an ice bath condition, namely intermittent emulsification, so as to obtain the W / O / W type temperature-sensitive embolization agent. According to the preparation method, intermittent emulsification is carried out under the ice bath condition, the stability of the prepared emulsion is guaranteed, the developing agent is dispersed in the outer water phase and the oil phase of the obtained W / O / W type temperature-sensitive embolic agent, the developing capacity of the embolic agent is guaranteed by adjusting the using amount of the developing agent, and due to the fact that the using amount of the developing agent in the outer water phase is adjustable, the stability of the embolic agent is guaranteed. Therefore, the embolism effect of the temperature-sensitive embolism agent is effectively ensured.

Description

technical field [0001] The invention relates to the technical field of embolization, and more specifically, relates to a preparation method of a W / O / W type thermosensitive embolism agent. Background technique [0002] Trans-Arterial Chemo-Embolization (TACE) is currently one of the most important treatments for advanced liver cancer, in which embolic agents play a pivotal role. The liquid embolic agent represented by lipiodol emulsion is currently the most widely used embolization material for hepatic tumor vessels, and the traditional chemoembolization based on lipiodol emulsion is called C-TACE (Convention-TACE). Lipiodol emulsion has good fluidity, can pass through microcatheter smoothly, and achieve tumor peripheral blood vessel embolization, but lipiodol emulsion has poor embolism, is easily washed away by blood and metabolized, and recanalization occurs. In this case, often It needs to be combined with solid embolic agents such as gelatin sponge (Gelation Sponge) and ...

Claims

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Application Information

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IPC IPC(8): A61L24/06A61L24/00
CPCA61L24/06A61L24/001A61L24/0015A61L24/0031A61L2430/36A61L2300/416
Inventor 李涵孙海霞刘宏杨祥良
Owner THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION