Method for synthesizing isononanal by using microchannel reaction device

A technology of microchannel reaction and microchannel reactor, which is applied in the direction of carbon monoxide reaction preparation, catalytic reaction, chemical instruments and methods, etc., can solve the problems of high equipment requirements, harsh reaction conditions, complicated process flow, etc., and achieve stable reaction system, The effect of improving reaction selectivity and improving reaction efficiency

Pending Publication Date: 2022-03-01
上海簇睿低碳能源技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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The reaction conditions of this process are harsh, the process f

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  • Method for synthesizing isononanal by using microchannel reaction device
  • Method for synthesizing isononanal by using microchannel reaction device
  • Method for synthesizing isononanal by using microchannel reaction device

Examples

Experimental program
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Effect test

Embodiment 1

[0071] 1-1) Rhodium dicarbonyl acetylacetonate, organophosphine ligand (formula (I-1)), toluene and diisobutylene mixture (2,4,4-trimethyl-1-pentene: 2,4,4 -trimethyl-2-pentene=81:19) is mixed with raw material liquid and adds in the liquid phase tank 1, wherein the concentration of dicarbonyl acetylacetonate rhodium in the solution is 100ppm, dicarbonyl acetylacetonate rhodium and organophosphine ligand ( The mol ratio of formula (I-1)) is 1:20;

[0072] 1-2) Feed the raw material liquid and the syngas into the Y-type microchannel mixer 2 simultaneously to obtain a gas-liquid mixed liquid, control and mix the mol ratio of diisobutylene and rhodium to be 5000:1, and the volume ratio of the raw material liquid to the syngas is 1:5, CO and H in syngas 2 The molar ratio is 1:1;

[0073] 1-3) Send the gas-liquid mixture into the microchannel reactor 3, and react at a reaction temperature of 80° C. and a reaction pressure of 1.0 MPa;

[0074] 1-4) The obtained crude product ente...

Embodiment 2

[0078] 2-1) Rhodium dicarbonyl acetylacetonate, organophosphine ligand (formula (I-2)), toluene and diisobutylene mixture (2,4,4-trimethyl-1-pentene: 2,4,4 -trimethyl-2-pentene=81:19) is mixed with raw material liquid and adds in the liquid phase tank 1, wherein the concentration of dicarbonyl acetylacetonate rhodium in the solution is 100ppm, dicarbonyl acetylacetonate rhodium and organophosphine ligand ( The mol ratio of formula (I-2)) is 1:20;

[0079] 2-2) Feed the raw material liquid and the syngas into the Y-shaped microchannel mixer 2 simultaneously to obtain a gas-liquid mixed liquid, control and mix the mol ratio of diisobutylene and rhodium to be 5000:1, and the volume ratio of the raw material liquid to the syngas is 1:5, CO and H in syngas 2 The molar ratio is 1:1;

[0080] 2-3) Send the gas-liquid mixture into the microchannel reactor 3, and react at a reaction temperature of 80° C. and a reaction pressure of 1.0 MPa.

[0081] 2-4) The product obtained enters t...

Embodiment 3

[0085] 3-1) Rhodium dicarbonyl acetylacetonate, organophosphine ligand (formula (I-3)), toluene and diisobutylene mixture (2,4,4-trimethyl-1-pentene: 2,4,4 -trimethyl-2-pentene=81:19) is mixed with raw material liquid and adds in the liquid phase tank 1, wherein the concentration of dicarbonyl acetylacetonate rhodium in the solution is 100ppm, dicarbonyl acetylacetonate rhodium and organophosphine ligand ( The mol ratio of formula (I-3)) is 1:20;

[0086] 3-2) Feed the raw material liquid and the syngas into the Y-shaped microchannel mixer 2 simultaneously to obtain a gas-liquid mixed liquid, control and mix the mol ratio of diisobutylene and rhodium to be 5000:1, and the volume ratio of the raw material liquid to the syngas is 1:5, CO and H in syngas 2 The molar ratio is 1:1;

[0087] 3-3) Send the gas-liquid mixture into the microchannel reactor 3, and react at a reaction temperature of 80° C. and a reaction pressure of 1.0 MPa;

[0088] 3-4) The obtained crude product en...

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Abstract

The invention discloses a method for synthesizing isononanal by a microchannel reaction device, which belongs to the technical field of organic chemical industry, and comprises the following steps: preparing a rhodium catalyst, an organic phosphine ligand and diisobutylene mixture into a raw material solution; the synthesis gas and the raw material liquid are pumped into the micro-channel mixer at the same time to be prepared into mixed liquid. Feeding the mixed solution into a micro-channel reactor for reaction to obtain a crude product, cooling the crude product by a cooler, feeding the crude product into a separation tank, emptying a gas phase, conveying a liquid phase to a liquid phase tank through a liquid phase pump for circular reaction, and obtaining a product after target reaction retention time is reached. According to the invention, the micro-channel reactor is adopted to synthesize isononanal, and the liquid-phase circulating system is adopted to reduce the large gas-liquid ratio required by isononanal synthesis to 20: 1 or below, so that the gas-liquid mixing effect is ensured, the reaction system is stable, the preparation time is shortened, and the production cost is reduced. In addition, proper types and proportions of the rhodium catalyst, the organic phosphine ligand and the diisobutylene mixture are matched and selected, so that the conversion rate reaches 90% or above, and the selectivity of isononanal reaches 90% or above.

Description

technical field [0001] The invention relates to the technical field of organic chemical industry, in particular to a method for synthesizing isononanal with a microchannel reaction device. Background technique [0002] As an important intermediate, isononanal (3,5,5-trimethylhexanal) can synthesize a variety of important organic compounds, such as isononanoic acid, isononanol, etc. Various fields and industries such as plasticizers, fragrances and surfactants. [0003] The hydroformylation reaction is an important reaction for the synthesis of aldehyde compounds. It has developed rapidly since it was discovered by Professor Otto Roelen in 1938 (Chem Abstr, 1994, 38-550), and has become the largest homogeneous catalytic reaction in industry. The catalysts for the hydroformylation reaction are mainly carbonyl complexes of Group VIII metals. Among them, rhodium-based catalysts have the best catalytic performance, and the catalytic performance of cobalt is only one-thousandth ...

Claims

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Application Information

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IPC IPC(8): B01J19/00C07C45/50C07C47/02B01J31/22
CPCB01J19/0093C07C45/50B01J31/185B01J2231/321B01J2531/822C07C47/02
Inventor 孙予罕王慧王栋梁宋文越焦玉佩范晨阳
Owner 上海簇睿低碳能源技术有限公司
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