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Active polypeptide with ACE (angiotensin converting enzyme) inhibition effect and application thereof

A technology of inhibitory and active peptides, applied in the field of biomedicine, can solve the problems that there are no rabbit meat-derived ACE inhibitory peptides, research reports, etc., and achieve good potential and application prospects, good blood pressure lowering, and sustained and stable inhibitory effects

Pending Publication Date: 2022-03-01
CHONGQING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on rabbit meat at home and abroad mainly focuses on the nutritional value, and there is no research report on the ACE inhibitory peptide derived from rabbit meat and its mechanism of action

Method used

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  • Active polypeptide with ACE (angiotensin converting enzyme) inhibition effect and application thereof
  • Active polypeptide with ACE (angiotensin converting enzyme) inhibition effect and application thereof
  • Active polypeptide with ACE (angiotensin converting enzyme) inhibition effect and application thereof

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Experimental program
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Effect test

Embodiment

[0019] 1. Preparation of ACE inhibitory peptide Mince rabbit meat, adjust the concentration to 50 mg / mL with distilled water, and homogenize for 2 minutes with a tissue homogenizer. The homogenate was inactivated in a boiling water bath for 10 minutes. After cooling, use five different enzymes (alkaline protease: 50°C, pH7.0; pepsin: 37°C, pH2.0; trypsin: 37°C, pH8.0; complex protease: 50°C, pH7.0 ; Bromelain: 55°C, pH7.0) hydrolyzes for 2, 3, 4, 5 or 6 hours under optimal conditions, the mass ratio of enzyme to rabbit meat is 1:10. During the hydrolysis, the pH of the reaction mixture was maintained by adding 0.5N NaOH or 0.5N HCl. The mixture was then boiled for 10 minutes to terminate the reaction, cooled rapidly to room temperature, and adjusted to pH 7.0. Then use a TGL-20 centrifuge to centrifuge at 10,000r / min for 20min at 4°C. The supernatant was filtered with filter paper, and freeze-dried in a lyophilizer to obtain rabbit meat protein hydrolyzate (RMPH). The ACE ...

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Abstract

The invention discloses an active polypeptide with an ACE (Angiotensin Converting Enzyme) inhibition effect. The amino acid sequence of the active polypeptide is WAGP. The active polypeptide with the ACE inhibiting effect has a continuous and stable inhibiting effect on the activity of ACE and has a good blood pressure lowering effect, so that the active polypeptide can be used as an active component in food, health care products and blood pressure lowering drugs and has good potential and application prospects.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to an active polypeptide with ACE inhibitory effect and application thereof. Background technique [0002] Hypertension is one of the most common cardiovascular diseases and an important risk factor for stroke, coronary heart disease, heart failure and other diseases. According to the statistics of the World Health Organization in 2020, about 1.13 billion people in the world suffer from high blood pressure, which has seriously threatened human health. Angiotensin-I converting enzyme (ACE) is a dipeptide carboxyl metalloprotease, in the renin-angiotensin system (Renin-Angiotensin System, RAS) and kallikrein-kinin system (Kallikrein -Kinin System, KKS) plays an important regulatory role. ACE inhibitors can reduce blood pressure by inhibiting ACE activity, preventing the conversion of angiotensin I to angiotensin II, and maintaining the activity of angiotensin bradykin...

Claims

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Application Information

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IPC IPC(8): C07K5/117A61K38/07A61P35/00A23L33/18
CPCC07K5/1024A61P35/00A23L33/18A61K38/00A23V2002/00A23V2200/326A23V2250/55Y02A50/30
Inventor 和七一余晓东陈峻波
Owner CHONGQING NORMAL UNIVERSITY
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