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Method for preparing functionalized magnetic polymer microspheres by miniemulsion polymerization method using porous microspheres as template

A technology of miniemulsion polymerization and porous microspheres, which is applied in the field of preparation of magnetic polymer microspheres, can solve the problems of non-uniform particle size of magnetic polymer microspheres, differences in the coverage rate of magnetic substances, and uncontrollability, and achieve strong universal application properties, achieve particle size, and achieve the effect of functional group modification

Pending Publication Date: 2022-03-01
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method is not only cumbersome, but the particle size of the obtained magnetic polymer microspheres is not uniform and uncontrollable, and the coating ratio of magnetic substances in the microspheres also has great differences.

Method used

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  • Method for preparing functionalized magnetic polymer microspheres by miniemulsion polymerization method using porous microspheres as template
  • Method for preparing functionalized magnetic polymer microspheres by miniemulsion polymerization method using porous microspheres as template
  • Method for preparing functionalized magnetic polymer microspheres by miniemulsion polymerization method using porous microspheres as template

Examples

Experimental program
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Effect test

Embodiment 1

[0031] (1) Synthesis of polystyrene seed microspheres: First, add isopropanol and distilled water with a mass ratio of 3:2 into a 50 mL three-necked flask, and stir to make them evenly mixed. Then 0.375g of polyvinylpyrrolidone, 2.5mL of styrene and 0.04g of azobisisobutyronitrile were added thereto, and the stirring was continued to make them evenly mixed. Under the protection of nitrogen, the temperature of the reaction solution was raised to 75° C. for 12 h. Centrifuge and wash with deionized water several times, and vacuum-dry the product for 12 hours to obtain polystyrene seed microspheres with a particle size of about 1 μm.

[0032] (2) Synthesis and hydrolysis of porous polymer microspheres:

[0033] a. Synthesis: Add 0.6mL toluene and 1.8mL dibutyl phthalate to 30mL aqueous solution containing 0.05g sodium lauryl sulfate, and ultrasonically emulsify it fully. Add 0.1 g of the polystyrene seed microspheres prepared in the above step (1), and swell at room temperature ...

Embodiment 2

[0037] (1) Synthesis of polystyrene seed microspheres: First, add isopropanol and distilled water with a mass ratio of 3:2 into a 50 mL three-necked flask, and stir to make them evenly mixed. Then 0.375g of polyvinylpyrrolidone, 2.5mL of styrene and 0.04g of azobisisobutyronitrile were added thereto, and the stirring was continued to make them evenly mixed. Under the protection of nitrogen, the temperature of the reaction solution was raised to 75° C. for 12 h. Centrifuge and wash with deionized water several times, and vacuum-dry the product for 12 hours to obtain polystyrene seed microspheres with a particle size of about 1 μm.

[0038] (2) Synthesis of porous polymer microspheres: 0.6 mL of toluene and 1.8 mL of dibutyl phthalate were added to 30 mL of aqueous solution containing 0.05 g of sodium lauryl sulfate, and ultrasonically emulsified fully. Add 0.1 g of the polystyrene seed microspheres prepared in the above step (1), and swell at room temperature for 12 h. Simila...

Embodiment 3

[0041] (1) Synthesis of polystyrene seed microspheres: First, add isopropanol and distilled water with a mass ratio of 3:2 into a 50 mL three-necked flask, and stir to make them evenly mixed. Then 0.375g of polyvinylpyrrolidone, 2.5mL of styrene and 0.04g of azobisisobutyronitrile were added thereto, and the stirring was continued to make them evenly mixed. Under the protection of nitrogen, the temperature of the reaction solution was raised to 75° C. for 12 h. Centrifuge and wash with deionized water several times, and vacuum-dry the product for 12 hours to obtain polystyrene seed microspheres with a particle size of about 1 μm.

[0042] (2) Synthesis and hydrolysis of porous cross-linked polymer microspheres:

[0043] a. Synthesis: Add 0.6mL toluene and 1.8mL dibutyl phthalate to 30mL aqueous solution containing 0.05g sodium lauryl sulfate, and ultrasonically emulsify it fully. Add 0.1 g of the polystyrene seed microspheres prepared in the above step (1), and swell at room...

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Abstract

The invention discloses a method for preparing a functionalized magnetic polymer microsphere by a miniemulsion polymerization method using a porous microsphere as a template. The method comprises the following steps: synthesizing a porous template polymer microsphere; preparing a uniform and stable magnetic fluid; the magnetic fluid is dispersed into a water phase containing a surfactant, the porous template polymer microspheres and an initiator are added, and the magnetic polymer microspheres are prepared through a miniemulsion polymerization method. According to the method, multiple steps are changed into one step, so that the problem that magnetic substances in the magnetic polymer microspheres are easy to leak and subsequent additional encapsulation and functional modification steps are avoided. Meanwhile, the porous microspheres with uniform particle sizes are used as templates, so that the problems that the sizes of magnetic polymer microspheres are not uniform and uncontrollable, the content of magnetic substances in the microspheres is low, and the coating rate difference of the magnetic substances is relatively large are solved. The magnetic polymer microspheres with uniform and controllable particle size, high magnetic substance content and different functional surfaces can be prepared by using the method disclosed by the invention.

Description

technical field [0001] The invention belongs to a method for preparing magnetic polymer microspheres, and in particular relates to a method for preparing functionalized magnetic polymer microspheres by a miniemulsion polymerization method using porous microspheres as a template. Background technique [0002] Magnetic polymer microspheres not only have the non-toxic and superparamagnetic properties of magnetic inorganic nanoparticles, but also have the characteristics of polarity, biocompatibility and easy surface functionalization of polymers. They are used in many fields, especially in biological detection and in vitro Wide range of applications in diagnostic reagents. Magnetic microspheres used in diagnostic reagents require uniform particle size, fast magnetic response, good suspension, and low non-specific adsorption to biological macromolecules such as proteins and nucleic acids. [0003] There are four main methods for preparing magnetic polymer microspheres: monomer ...

Claims

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Application Information

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IPC IPC(8): C08F265/06C08F257/02C08F220/14C08F212/36C08F220/32C08K9/04C08K3/22
CPCC08F265/06C08F257/02C08K9/04C08K3/22C08K2003/2275C08K2201/011C08K2201/01C08F220/14C08F212/36C08F220/325
Inventor 姜勇满红聂莹芮王志飞汪洋张金泉
Owner SOUTHEAST UNIV
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