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High density microchannel

A technology of microchannels and channels, applied in the direction of microorganisms, separation methods, prostheses, etc., can solve the problems of hydrogel lack of directionality and neuron guidance ability

Pending Publication Date: 2022-03-01
SPIDERWORT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydrogels often lack directionality and neuronal guidance

Method used

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  • High density microchannel
  • High density microchannel
  • High density microchannel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-

[0470] Preparation of embodiment 1-high density microchannel (HDMC) and its biocompatibility analysis

[0471] Described herein are methods for isolating and decellularizing individual vascular bundles or vascular tissue of any suitable plant while aiming at avoiding or minimizing the introduction of treatment residues or contaminants. Bundling / densification of these vascular channels or tissues by various glues and sealants, including natural-sourced and / or synthetic glues, was studied. The generation of a custom mold technique is described that provides the gluing of vascular bundles (or generally any plant microchannel structure) arranged in 3D without substantially disrupting or introducing impurities.

[0472] In the present study, transport structures present in plant vascular bundles (ie, xylem and phloem channels) were used to prepare bundles of high-density microchannels (HDMCs) for various applications. In plants, xylem and phloem channels mainly transport water and...

Embodiment 2

[0496] Example 2 - Example of a standard operating procedure (SOP) developed for the extraction and isolation of plant or fungal (ie AS) vascular bundles (VB)

[0497] Examples of standard operating procedures (SOPs) developed for the extraction and isolation of plant or fungal vascular bundles and / or microchannels are described below. This SOP was used to extract and isolate vascular bundles from AS sources.

[0498] Safety statement

[0499] Prevent accidental incisions by maintaining awareness of the surgical blade position and the sides of the microtome blade. Reference to all applicable MSDSs. Wear appropriate personal protective equipment such as plastic gloves, lab coat, and goggles.

[0500] the solution

[0501] Dulbecco's Phosphate Buffered Saline

[0502] DPBS (Hyclone, catalog number no. 350-000-CL) bottle 500ml

[0503] Store at 4°C protected from light.

[0504] Do not use after expiration date.

[0505] program

[0506] Choice of asparagus

[0507]...

Embodiment 3

[0556] Example 3 - Example of a standard operating procedure (SOP) developed for the extraction and isolation of plant or fungal (ie CL) vascular bundles (VB)

[0557] Examples of standard operating procedures (SOPs) developed for the extraction and isolation of plant or fungal vascular bundles and / or microchannels are described below. This SOP was used to extract and isolate vascular bundles from CL sources.

[0558] Safety statement

[0559] Prevent accidental incisions by maintaining awareness of the surgical blade position and the sides of the microtome blade. Reference to all applicable MSDSs. Wear appropriate personal protective equipment such as plastic gloves, lab coat, and goggles.

[0560] the solution

[0561] Dulbecco's Phosphate Buffered Saline

[0562] DPBS (Hyclone, catalog number no. 350-000-CL) bottle 500ml

[0563] Store at 4°C protected from light.

[0564] Do not use after expiration date.

[0565] program

[0566] celery of choice

[0567] Ch...

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PUM

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Abstract

Provided herein are scaffold biomaterials comprising at least one bundle of microchannels having a plurality of decellularized microchannels isolated from a plant or fungal tissue, the decellularized microchannels arranged substantially parallel to each other within the bundle. Methods and uses of the scaffold biomaterials and bundles, as well as methods for producing the scaffold biomaterials and bundles, are also provided.

Description

technical field [0001] The present invention generally relates to scaffold biomaterials. More specifically, the present invention relates to high density decellularized microchannel bundles derived from plant tissue and their use as scaffold biomaterials. Background technique [0002] The biomaterials industry is estimated to have a market value of $90 billion and is driven by novel materials derived from natural sources, synthetic polymers, metals and ceramics. These materials can form stereoscopic high-porosity scaffolds with nanoscale / microscale structures that are biocompatible and promote the growth of living cells. For example, new biomaterials that support the invasion and proliferation of living cells are of great interest for their potential applications in tissue engineering and regenerative medicine. [0003] Biomaterial scaffolds have applications in several segments including dentistry and cosmetic surgery, clinical and medical therapies such as regenerative m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/04A61K47/46A61L27/50B01D11/02C08J5/12C09J5/00C12N1/14C12N5/00C12N5/07
CPCB01D11/0288B01D11/0257A61L2430/38A61L27/3637A61L27/3683A61L27/3804A61L27/54A01H4/002A61K47/46A61L27/38A61L27/3878C09K5/14C12N5/0068C12N5/04
Inventor M-A·费尔科C·柯里尔M·勒布朗·拉图尔S·汉森D·莫杜里维斯基A·E·佩林K·奥雷塞夫斯基
Owner SPIDERWORT INC