Dextromethorphan hydrobromide oral solution

A technology of dextromethorphan hydrobromide and sodium bisulfite, which is applied in the directions of dispersion liquid delivery, inorganic inactive ingredients, and drug combination, etc., can solve the problems of easy precipitation and crystallization, poor oral compliance of patients, and poisoning of essences.

Active Publication Date: 2022-03-11
JIANGSU HANCHEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Yet existing dextromethorphan hydrobromide oral solution still has many disadvantages, such as dextromethorphan hydrobromide has bitter taste, and bitter taste causes poor oral compliance of patients, especially children, even if existing dextromethorphan hydrobromide is oral The solution increases the sweetness of the oral solution by adding sweeteners such as sucrose, glucose, etc., and improves the mouthfeel. However, even the addition of sweeteners still has the problem of bitterness and bitterness. In order to further overcome the bitterness of the oral solution, now Some dextromethorphan hydrobromide oral solutions usually cover the bitter taste by adding various essences such as orange essence, zest essence and lemon essence etc. to improve the taste and local flavor of the oral solution. problems, and the flavor has a toxic effect, which is not conducive to the health of the human body, especially for underdeveloped children
In addition, the stability of dextromethorphan hydrobromide oral solution is easily affected by various factors, especially factors such as light and heat, resulting in reduced co

Method used

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  • Dextromethorphan hydrobromide oral solution
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Examples

Experimental program
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Embodiment 1

[0164] Present embodiment 1 provides a kind of dextromethorphan hydrobromide oral solution, and the prescription of dextromethorphan hydrobromide oral solution is as shown in table 1 below:

[0165] The prescription composition of table 1 dextromethorphan hydrobromide oral solution (specification 1.5mg / ml)

[0166] components Dosage Dextromethorphan Hydrobromide 0.15g Sucralose 0.07g Hydroxyethyl cellulose 0.2g ethanol 2.0g glycerin 4.0g Xylitol 4.0g Sorbitol 6.0g fructose 8.0g sodium bisulfite 0.08g Disodium edetate 0.1g purified water up to 100ml

[0167] The preparation method of the dextromethorphan hydrobromide oral solution of present embodiment 1 is as follows:

[0168] (1) Boil the prescribed amount of purified water, keep it for 10 minutes, and set aside.

[0169] (2) After mixing 45% of the purified water of the prescribed amount, the glycerol of the prescribed amount and the ethanol o...

Embodiment 2

[0173] Present embodiment 2 provides a kind of dextromethorphan hydrobromide oral solution, and the prescription of dextromethorphan hydrobromide oral solution is as shown in table 2 below:

[0174] The prescription composition of table 2 dextromethorphan hydrobromide oral solution (specification 1.5mg / ml)

[0175] components Dosage Dextromethorphan Hydrobromide 0.15g Sucralose 0.07g ethanol 2.0g Xylitol 4.0g Sorbitol 6.0g fructose 8.0g sodium bisulfite 0.08g Disodium edetate 0.1g purified water up to 100ml

[0176] The preparation method of the dextromethorphan hydrobromide oral solution of present embodiment 2 is as follows:

[0177] (1) Boil the prescribed amount of purified water, keep it for 10 minutes, and set aside.

[0178] (2) After mixing 45% of the purified water of the prescribed amount and the ethanol of the prescribed amount, a mixed solvent is obtained, and the temperature of the mixed solven...

Embodiment 3

[0182] Present embodiment 3 provides a kind of dextromethorphan hydrobromide oral solution, and the prescription of dextromethorphan hydrobromide oral solution is as shown in table 3 below:

[0183] The prescription composition of table 3 dextromethorphan hydrobromide oral solution (specification 1.5mg / ml)

[0184] components Dosage Dextromethorphan Hydrobromide 0.15g Sucralose 0.07g Hydroxyethyl cellulose 0.2g ethanol 2.0g glycerin 4.0g Sorbitol 6.0g fructose 8.0g sodium bisulfite 0.08g Disodium edetate 0.1g purified water up to 100ml

[0185] The preparation method of the dextromethorphan hydrobromide oral solution of present embodiment 3 is as follows:

[0186] (1) Boil the prescribed amount of purified water, keep it for 10 minutes, and set aside.

[0187] (2) After mixing 45% of the purified water of the prescribed amount, the glycerol of the prescribed amount and the ethanol of the prescribed am...

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Abstract

The invention relates to a dextromethorphan hydrobromide oral solution. Specifically, the invention provides the pharmaceutical composition, and the pharmaceutical composition comprises dextromethorphan hydrobromide, a flavoring agent, a stabilizer, a complexing agent, an antioxidant and a solvent. The dextromethorphan hydrobromide oral solution disclosed by the invention has excellent mouth feel and stability.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a dextromethorphan hydrobromide oral solution. Background technique [0002] Dextromethorphan hydrobromide, the chemical name is 3-methoxy-17-methyl-(92,132,142) morphinan hydrobromide, the CAS number is 125-69-9, and the structural formula is as follows: [0003] [0004] Dextromethorphan Hydrobromide [0005] Dextromethorphan hydrobromide is often used as an antitussive for the central nervous system, mainly for dry cough, suitable for coughs caused by colds, acute or chronic bronchitis, bronchial asthma, pharyngitis, tuberculosis and other upper respiratory tract infections. [0006] Existing dextromethorphan hydrobromide preparations mainly include tablet, capsule, injection and oral solution. Among various dosage forms, tablets and capsules involve the dissolution of the drug, and the onset of action is slow. Tablets and capsules cannot guarantee the complete ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/485A61K47/26A61K47/38A61K47/10A61K47/02A61K47/18A61P11/14
CPCA61K9/0095A61K31/485A61K47/26A61K47/38A61K47/10A61K47/02A61K47/183A61P11/14
Inventor 孙先法顾姣姣何鹏华徐智阳
Owner JIANGSU HANCHEN PHARMA
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