Coating method of woven artificial blood vessel and artificial blood vessel

An artificial blood vessel and coating technology, which is applied in the field of medical devices, can solve the problems of uneven inner and outer surfaces of artificial blood vessels, expensive imported artificial blood vessels, and difficulty in uniform coating, so as to shorten the waiting time for surgery, protect elasticity and compliance , good adhesion effect

Active Publication Date: 2022-03-11
山东欣脉通生物科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Imported artificial blood vessels are not only expensive, but also have a long lead time
[0003] At present, coating technology is one of the main bottlenecks in the research and development of artificial blood vessels in China. There are many researches and developments in coatings for artificial blood vessels in China, but most of them are coated after texture, and the artificial blood vessels after texture are convex and concave. The spiral corrugated tube formed by alternate combination and rotation, from the perspective of the whole artificial blood vessel, there is a change in the inner diameter in the axial direction, the inner and outer surfaces of the artificial blood vessel are extremely uneven, and the surface tension of the coating solution is different at the peak and trough of the artificial blood vessel. It is difficult to achieve uniform coating, and there is no mature coating technology at present

Method used

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  • Coating method of woven artificial blood vessel and artificial blood vessel
  • Coating method of woven artificial blood vessel and artificial blood vessel
  • Coating method of woven artificial blood vessel and artificial blood vessel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 8mm diameter artificial vascular coating.

[0039] First, degrease the braided artificial blood vessels, refining agent 3g / L, NaHCO 3 5g / L, liquor ratio 1:10, 90℃, treatment for 30min. Wash with deionized water three times, then bake at 60°C for 20 minutes.

[0040] Then, the degreased braided blank tube is coated with a 5% mass fraction and a bio-grade polyurethane solution as an active ingredient. Pad coating is adopted, the pressure is 2Bar, the vehicle speed is 2m / min, and hot air drying is adopted, the drying temperature is 50°C, and the drying time is 1h.

[0041] After the braided blank tube is coated, texture is carried out. The blank tube after texture is made of albumin as the active ingredient, and ultrapure water is used as the solvent to prepare a solution with a concentration of 5%. Conduct chemical cross-linking with 0.05% acetaldehyde, and then put it into a vacuum drying oven for drying at a temperature of 45° C. and a drying time of 6 hours to obta...

Embodiment 2

[0046] 18mm diameter artificial vascular coating.

[0047] First, degrease the braided artificial blood vessels, refining agent 5g / L, NaHCO 3 9g / L, liquor ratio 1:10, 90℃, treatment for 30min. Wash with deionized water 4 times, then bake at 60°C for 30 minutes.

[0048] Then, the degreased braided blank tube is coated with a polyester solution with a mass fraction of 8% and an active ingredient of biological grade. Pad coating is adopted, the pressure is 2.5Bar, the vehicle speed is 2.5m / min, and hot air drying is adopted, the drying temperature is 60°C, and the drying time is 1h.

[0049] After the braided blank tube is coated, patterning is carried out. The blank tube after patterning uses grade heparin as the active ingredient, and uses ultrapure water as the solvent to prepare a solution with a concentration of 8%. Perform chemical cross-linking for 1% formaldehyde, and then put it into a vacuum drying oven for drying at a temperature of 35° C. and a drying time of 8 h...

Embodiment 3

[0052] 28mm diameter artificial vascular coating.

[0053] First, degrease the braided artificial blood vessels, refining agent 5g / L, NaHCO 3 10g / L, liquor ratio 1:10, 90℃, treatment for 30min. Wash with deionized water 3 times, then bake at 60°C for 40min.

[0054] Then, the degreased braided blank tube is coated with a 10% mass fraction and a bio-grade polyurethane solution as an active ingredient. Pad coating is adopted, the pressure is 3.0Bar, the vehicle speed is 3m / min, and hot air drying is adopted, the drying temperature is 50°C, and the drying time is 1h.

[0055] After coating the woven blank tube, it is textured. The textured blank tube uses biological grade silk fibroin as the active ingredient, and uses ultra-pure water as the solvent to prepare a solution with a concentration of 6%, and coats it by pouring the coating. Then use glutaraldehyde at a concentration of 0.1% for chemical cross-linking, and then put it into a vacuum drying oven for drying at a tempe...

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Abstract

The invention belongs to the technical field of medical instruments, and particularly relates to a coating method of a woven artificial blood vessel and the woven artificial blood vessel. According to the method, a step-by-step coating mode is adopted, the braided tube blank is firstly coated, and the coating is performed under the flat state of the tube blank, so that the contact surface tension of the coating solution and the artificial blood vessel is consistent, the uniformity of the coating is solved, and meanwhile, the water permeation amount of the artificial blood vessel is also effectively reduced; according to the artificial blood vessel and the preparation method thereof, the artificial blood vessel prepared by the method is uniform in coating, small in overall water permeation amount and good in biocompatibility, good elasticity and compliance of the artificial blood vessel are maintained, and the artificial blood vessel has the advantages of being simple in process, convenient to operate, low in cost and good in application prospect. The prepared artificial blood vessel is stored after sterilization, does not need to be pre-coagulated before implantation, and can be directly used for clinical transplantation after being soaked in normal saline.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a coating method of a braided artificial blood vessel and the artificial blood vessel. Background technique [0002] With the improvement of people's living standards, the incidence of cardiovascular diseases is also increasing, and the demand for artificial blood vessels is increasing year by year. At present, there are many domestic researches on artificial blood vessels, but clinically, imported artificial blood vessels are still the mainstay. Imported artificial blood vessels are not only expensive, but also have a long lead time. [0003] At present, coating technology is one of the main bottlenecks in the research and development of artificial blood vessels in China. There are many researches and developments in coatings for artificial blood vessels in China, but most of them are coated after texture, and the artificial blood vessels after texture are c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/34A61L27/22A61L27/54A61L27/20A61F2/06A61F2/07
CPCA61L27/507A61L27/50A61L27/34A61L27/227A61L27/54A61L27/20A61F2/06A61F2/07A61L2400/00A61L2430/22A61L2420/02C08L75/04C08L89/00C08L67/00C08L5/10
Inventor 刘玉杰房宽峻孙涵刘迪杨毅朱蕾李屹杭
Owner 山东欣脉通生物科技有限公司
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