Antibacterial coating as well as preparation method and application thereof

An antibacterial coating and coating technology, applied in coatings, pharmaceutical formulations, catheters, etc., can solve the problems of single composition of antibacterial coatings, uncontrolled drug release, bacterial resistance, etc., to achieve excellent antibacterial effect, maintain Effectiveness of bactericidal concentration time, excellent lubricating action

Active Publication Date: 2022-03-15
INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method of inhibiting bacterial biofilm is mainly based on different reagents and loading methods, and less attention is paid to the release curve of a single drug, that is, the drug release cannot be controlled.
The main reason is that the composition of the current antibacterial coating is relatively simple. The antibiotic coating currently used in clinical practice will release most of the drug in a short period of time when loaded with drugs, and the drug concentration cannot maintain the minimum bactericidal concentration for a long time, which is easy to promote The emergence of bacterial resistance

Method used

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  • Antibacterial coating as well as preparation method and application thereof
  • Antibacterial coating as well as preparation method and application thereof
  • Antibacterial coating as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] This embodiment has prepared a kind of silicone rubber that is coated with drug-loaded microsphere coating, and specific process is:

[0047]S1: Preparation of CHI-C solution: Chitosan (130 kDa, 3.25 mmol) and dihydroxyphenylpropionic acid (HCA, 6.49 mmol) were dissolved in PBS (50 mL, pH=5). Then EDC (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 6.49mmol) was added to the mixture, stirred at room temperature for 12 hours, after extensive dialysis (Mw: 3500) Afterwards, store the product in a centrifuge tube.

[0048] S2: Preparation of antibacterial coating: Take 1.8g of CHI-C solution, add 20mg of triclosan-loaded PLGA microspheres and 20mg of chlorhexidine-loaded PLGA microspheres, and stir on a magnetic stirrer at a stirring rate of 500rpm-1000rpm ;

[0049] S3: Preparation of silicone rubber: Spin-coat the mixed solution on the surface of the silicone rubber, and dry in an oven at 50°C.

Embodiment 2

[0051] This embodiment has prepared a kind of silicone rubber that is coated with drug-loaded microsphere coating, and specific process is:

[0052] S1: Preparation of CHI-C solution: Chitosan (130 kDa, 3.25 mmol) and dihydroxyphenylpropionic acid (HCA, 3.25 mmol) were dissolved in PBS (50 mL, pH=5). Then EDC (3.25 mmol) was added to the mixture, stirred at room temperature for 12 hours, and after extensive dialysis (Mw: 3500), the product was stored in a centrifuge tube.

[0053] S2: Preparation of antibacterial coating: take 1.8 g of CHI-C solution, add 40 mg of triclosan-loaded PLGA microspheres, and stir on a magnetic stirrer at a stirring rate of 500 rpm to 1000 rpm;

[0054] S3: The mixed solution was spin-coated on the surface of the silicone rubber, and dried in an oven at 50° C. to obtain the silicone rubber CHI-C+TMS.

Embodiment 3

[0056] This embodiment has prepared a kind of silicone rubber that is coated with drug-loaded microsphere coating, and specific process is:

[0057] S1: Preparation of CHI-C solution: Chitosan (130 kDa, 3.25 mmol) and dihydroxyphenylpropionic acid (HCA, 9.75 mmol) were dissolved in PBS (50 mL, pH=5). Then EDC (9.75 mmol) was added to the mixture, stirred at room temperature for 12 hours, and after extensive dialysis (Mw: 3500), the product was stored in a centrifuge tube.

[0058] S2: Preparation of antibacterial coating: take 1.8g of CHI-C solution, add 40mg of chlorhexidine-loaded PLGA microspheres, stir on a magnetic stirrer, and the stirring rate is 500rpm-1000rpm;

[0059] S3: The mixed solution was spin-coated on the surface of the silicone rubber, and dried in an oven at 50° C. to obtain the silicone rubber CHI-C+CMS.

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Abstract

The invention provides an antibacterial coating as well as a preparation method and application thereof, the antibacterial coating comprises a modified chitosan coating and polylactic acid-glycolic acid copolymer microspheres, and the polylactic acid-glycolic acid copolymer microspheres are loaded on the surface of the modified chitosan coating. The antibacterial coating can load at least one medicine, so that the synergistic effect among the medicines can be realized, the generation of the medicine resistance can be reduced, the effect of slowly releasing the medicines can be achieved through the PLGA microspheres, the medicine release time can be prolonged, the minimum bactericidal concentration time of the medicines can be maintained, and the catheter blockage time can be prolonged.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an antibacterial coating and a preparation method and application thereof. Background technique [0002] Urinary catheter is a common clinical medical device, which is a tubular device inserted into the bladder cavity through the urinary tract for the purpose of urinating and flushing the bladder. At present, the catheters used clinically are mainly silicone rubber, latex (including siliconized latex catheters), polyvinyl chloride, etc. The urinary tract infection caused by the catheter is mainly due to the long-term built-in of the catheter, which leads to external Bacteria can adhere and reproduce in a suitable environment, and then form a biofilm. The drug resistance of bacteria is enhanced and it is difficult to remove. Catheter-associated urinary tract infection is the most common cause of iatrogenic urinary tract infection, accounting for up to 80% of urina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/06A61L29/14A61L29/16
CPCA61L29/085A61L29/06A61L29/08A61L29/14A61L29/16A61L2300/404A61L2300/236A61L2300/602A61L2300/606A61L2400/18A61L2420/02A61L2420/06C08L67/04C08L5/08C08L83/04
Inventor 林承雄黄正宇王耀程赵瑞芳张锦
Owner INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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