Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Plugging anti-adhesion membrane material and preparation method thereof

An anti-adhesion film and blocking technology, applied in the field of biomedical materials, can solve the problems of adhesion and easy loss of anti-adhesion, and achieve the effect of reducing the formation of thrombus, reducing platelet activation, and meeting clinical needs.

Pending Publication Date: 2022-03-15
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
View PDF7 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies of the above-mentioned prior art, the present invention provides a blocking anti-adhesion film material and a preparation method thereof. The technical problem that the sealant material with hemostatic function is easy to lose the anti-adhesion function when it adheres to the anti-adhesion film after completing the hemostatic function

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Plugging anti-adhesion membrane material and preparation method thereof
  • Plugging anti-adhesion membrane material and preparation method thereof
  • Plugging anti-adhesion membrane material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation method of the sealing anti-adhesion film material provided in this embodiment, the specific technical scheme is as follows:

[0033] (1) Preparation of anti-adhesion film by electrospinning

[0034] Prepare PLGA solution, PLGA (PLA / PGA=75 / 25, molecular weight 60,000) polymer content is 50% (w / v), add 5*10 -5 g / mLVEGF, the solvent is a mixed solution of DMF and acetone (volume ratio is 1 / 1). The solution was placed on a magnetic stirrer and stirred at room temperature for 3-5 hours, transferred into a syringe and then spun. The spinning temperature is about 25°C, the humidity is controlled at about 50%, the voltage is 15-20kv, and the propulsion rate is 20-50μL / min to obtain a fiber membrane with a thickness of 70-170μm and a fiber diameter of 1-2μm. Store in a vacuum oven at room temperature.

[0035] (2) Preparation of hemostatic gel

[0036] Remove water from polytetrahydrofuran under reduced pressure and vacuum at 120°C for 3 hours, cool to 40°C, ...

Embodiment 2

[0041] The preparation method of the sealing anti-adhesion film material provided in this embodiment, the specific technical scheme is as follows:

[0042] (1) Preparation of anti-adhesion film by electrospinning

[0043] A solution of PLGA and PCL (the mass ratio of the two is 90 / 10) is prepared, the total polymer content is 30% (w / v), and the solvent is a mixed solution of DMF and acetone (the volume ratio is 1 / 1). The solution was placed on a magnetic stirrer and stirred at room temperature for 3-5 hours, transferred into a syringe and then spun. The spinning temperature is about 20°C, the humidity is controlled at about 40%, the voltage is 15-20kv, and the propulsion rate is 20-50μL / min to obtain a fiber membrane with a thickness of 70-170μm and a fiber diameter of 1-2μm. Store in a vacuum oven at room temperature.

[0044] Dip the electrospun membrane into KMnO 4 H 2 SO 4 (1.2N) solution for oxidation treatment, followed by washing with HCl and pure water and drying ...

Embodiment 3

[0051] The preparation method of the sealing anti-adhesion film material provided in this embodiment, the specific technical scheme is as follows:

[0052] (1) Preparation of anti-adhesion film by electrospinning

[0053] A solution of PLA and PLGA (90 / 10 in mass ratio) was prepared, the total polymer content was 20% (w / v), and the solvent was a mixed solution of DMF and acetone (1 / 1 in volume ratio). The solution was placed on a magnetic stirrer and stirred at room temperature for 3-5 hours, transferred into a syringe and then spun. The spinning temperature is about 30°C, the humidity is controlled at about 55%, the voltage is 15-20kv, and the propulsion rate is 20-50μL / min to obtain a fiber membrane with a thickness of 70-170μm and a fiber diameter of 1-2μm. Store in a vacuum oven at room temperature.

[0054] The anti-blocking fibrous membrane was immersed in a 10% (v / v) solution of silane (APTES) dissolved in anhydrous hexane to covalently bond aminosilane chains to the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a plugging anti-adhesion membrane material and a preparation method thereof. According to the preparation method of the plugging anti-adhesion membrane material, provided by the invention, direct coating is combined, direct forming is realized, the forming method is simple, and the selected materials are safe, nontoxic and degradable materials, so that a guarantee is provided for the safety of the prepared plugging anti-adhesion membrane material. The endothelial cells play an important role in the aspects of anticoagulation, cell proliferation regulation and thrombus formation inhibition, anti-adhesion material surface endothelial cellularization can be achieved, thrombus formation and platelet activation can be reduced, and the obvious influence on material blood compatibility improvement is achieved. According to the plugging anti-adhesion membrane material, the degradation time of the hemostatic gel on the outer layer is different from that of the endothelialization electrostatic spinning anti-adhesion membrane on the inner layer, the hemostatic effect in the early stage is achieved, the anti-adhesion effect in the later stage is achieved, and clinical requirements are met.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a blocking anti-adhesion film material and a preparation method thereof. Background technique [0002] In recent years, with the rapid development of cardiovascular surgery at home and abroad, the number of cases of cardiac surgery is increasing day by day, and the proportion of patients requiring repeat cardiac surgery has also increased significantly. Bleeding is a common phenomenon in surgical operations. Commonly used materials for bleeding include hemostatic microspheres, hemostatic gauze, hemostatic sponge and hemostatic sealant, which can greatly reduce intraoperative bleeding and postoperative complications, thereby improving surgical results. Among them, the hemostatic sealant has high strength and certain tissue adhesion, and can complete hemostasis through physical sealing without being affected by anticoagulant drugs. [0003] Current medical...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/14A61L31/06A61L31/08A61L31/10D04H1/728
CPCD04H1/728A61L31/148A61L31/16A61L31/10A61L31/08A61L31/06A61L2300/418A61L2300/42A61L2300/252A61L2300/256A61L2300/414
Inventor 杨美平张诺滋马靖瑶王思宁李琦
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com