Application of berberine hydrochloride in improving early brain injury after subarachnoid hemorrhage

A technology of berberine hydrochloride and subarachnoid space is applied in the application field of berberine hydrochloride in improving early brain injury after subarachnoid hemorrhage, and can solve problems such as the regulation of energy metabolism that is poorly understood.

Pending Publication Date: 2022-03-18
陈罡
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Problems solved by technology

Studies have shown that berberine hydrochloride can participate in acetylation by upregulating SIRT3 and promote cellular glycolysis in the pancreas, but little is known about the regulation of energy metabolism in the central nervous system

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  • Application of berberine hydrochloride in improving early brain injury after subarachnoid hemorrhage
  • Application of berberine hydrochloride in improving early brain injury after subarachnoid hemorrhage
  • Application of berberine hydrochloride in improving early brain injury after subarachnoid hemorrhage

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Embodiment Construction

[0028] Subarachnoid hemorrhage is a common hemorrhagic cerebrovascular disease with high mortality and disability. Tumor necrosis factor receptor-associated protein 1 (TRAP1) in mitochondria plays a role in metabolic mode switching of aerobic oxidation and glycolysis. Acetylation is an important post-translational modification process. However, it remains unclear how TRAP1 and acetylated TRAP1 regulate energy metabolism after SAH. Berberine hydrochloride, an isoquinoline alkaloid in traditional Chinese medicine, regulates the expression of sirtuins 3 (SIRT3). In our experiments, we performed western blotting, metabolite assays, TUNEL staining, and behavioral tests to explore the metabolic mode switch after subarachnoid hemorrhage and the effect of TRAP1 acetylation after berberine hydrochloride intervention.

[0029] The results showed that after subarachnoid hemorrhage, the content of adenosine triphosphate, glucose and pyruvate decreased, but the content of lactate increas...

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Abstract

The invention discloses application of berberine hydrochloride in improvement of early brain injury after subarachnoid hemorrhage. According to the invention, western blotting, metabolite determination, TUNEL staining and behavior testing are carried out to research the energy metabolism process after subarachnoid hemorrhage. It is speculated that berberine hydrochloride can promote deacetylation of TRAP1 protein by increasing mitochondrial deacetylase SIRT3; the berberine hydrochloride promotes glycolysis of neurons, provides energy for the neurons, increases the activity of succinate dehydrogenase and reduces active oxygen after subarachnoid hemorrhage.

Description

technical field [0001] The invention relates to the application of berberine hydrochloride in improving early brain injury after subarachnoid hemorrhage. Background technique [0002] Subarachnoid hemorrhage is a serious cerebrovascular disease with high morbidity and mortality. Different causes can lead to subarachnoid hemorrhage, such as ruptured cerebral aneurysm, arteriovenous malformation, moyamoya disease, and cerebral amyloid angiopathy. Although significant progress has been made in surgical operation and clinical treatment, the mortality rate of subarachnoid hemorrhage is still between 25% and 35%. Evidence suggests that early brain injury is a major contributor to poor prognosis after subarachnoid hemorrhage. Adenosine triphosphate is an important energy substrate for physiological activities. In the central nervous system, neurons complete neurotransmitter conduction and electrical signal transmission by supplementing adenosine triphosphate. The synthesis of A...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P25/00
CPCA61K31/4375A61P25/00
Inventor 陈罡王宗启李海英王中
Owner 陈罡
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