Medical composition comprising adipose tissue-derived extracellular matrix and method for producing same

A kind of technology of adipose tissue and manufacturing method, which is applied in the fields of pharmaceutical formulation, medical science, drug delivery, etc., can solve the problems of volume maintenance, etc., and achieve the effect of improving viscoelastic properties and excellent volume maintenance in the body

Active Publication Date: 2022-03-18
爱恩斯生物科技(昆山)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as stated or The current medical product is a simple form of micronized human adipose tissue-derived extracellular matrix powder hydrated in sterile saline, so it has the disadvantage of being difficult to maintain volume in the body after use

Method used

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  • Medical composition comprising adipose tissue-derived extracellular matrix and method for producing same
  • Medical composition comprising adipose tissue-derived extracellular matrix and method for producing same
  • Medical composition comprising adipose tissue-derived extracellular matrix and method for producing same

Examples

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Embodiment approach

[0094] Hereinafter, the present invention will be described more specifically by way of examples. However, the scope of the present invention is not limited to the following examples, and those skilled in the art should understand that various variations, modifications, or applications can be made within the range derived from the ideas described in the claims without departing from the technical ideas.

Embodiment 1

[0096] Example 1. Medical composition in which human adipose tissue-derived extracellular matrix particles and chemically cross-linked biocompatible polymers are physically mixed

[0097] (1) Manufacture of extracellular matrix derived from human adipose tissue

[0098] Fat is removed by pulverizing human adipose tissue with a pulverizer. In order to remove undesorbed fat, a 16-hour degreasing process was performed using 40% to 60% isopropanol and 40% to 60% hexane. Cells were removed by treating fat-depleted tissue with 0.1 N sodium hydroxide (NaOH).

[0099] In order to clean and remove the extracellular matrix of fat and cells, centrifuge at 8000rpm for 10 minutes to remove the supernatant, and repeat the washing process 5 to 10 times. The scaffold is freeze-dried so that the moisture content of the human adipose tissue-derived extracellular matrix is ​​less than 10%, preferably 1% to 8%.

[0100] The human adipose tissue-derived extracellular matrix that has been freeze...

experiment example 1

[0108] Experimental example 1. Verification of dosage form maintenance ability when medical composition is sterilized by radiation

[0109] (1) method

[0110] The dosage form maintenance ability of the medical composition produced in Example 1 was verified.

[0111] After preparing the samples with the contents in Table 1 below (remainder: sterilized physiological saline), they were sterilized with 25 kGy gamma rays. The physical properties by the content ratio of each component are confirmed at the time of gamma sterilization.

[0112] 【Table 1】

[0113]

[0114]

[0115] On the one hand, the pressing force on each sample was measured. Regarding the extrusion force, the maximum load value N is measured by using a universal testing machine, that is, the sleeve (cannula) is fixed to the syringe with the contents, and the syringe is pressed at a test speed of 12mm / min, so that the syringe The maximum load value N when the contents in the casing are discharged to the o...

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Abstract

The present invention relates to: a medical composition comprising an adipose tissue-derived extracellular matrix powder; and a biocompatible polymer or a crosslinked product of a biocompatible polymer. The medical composition according to the present invention is still present in an excellent agglutination state after being transplanted into a body, and can maintain a volume for a certain period of time.

Description

technical field [0001] The present invention relates to a medical composition comprising an adipose tissue-derived extracellular matrix and a method for producing the same. More specifically, it relates to a medical composition including homogeneous and heterogeneous adipose tissue-derived extracellular matrix powder; and a biocompatible polymer or a cross-linked product of a biocompatible polymer, and a method for producing the same. Background technique [0002] The purpose of regenerative medicine is to replace or regenerate human cells, tissues and organs. Traumatic trauma that leads to tissue damage and loss of function, and new diseases brought about by the sophistication of society provide an inevitable motivation for the faster development of regenerative medicine. [0003] Medical substances used in the field of regenerative medicine should be carefully selected according to the type of tissue and organ to be applied, the type of disease or trauma, and the case of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/36A61L27/50A61L15/40A61L15/28A61L15/42
CPCA61L27/20A61L27/36A61L27/50A61L15/40A61L15/28A61L15/42A61L2400/06C08L5/08C08L1/286A61L27/3633A61L27/24A61L2430/40A61L27/26C08L5/04C08L1/28C08L89/06A61L15/225A61L15/34
Inventor 金相澈李基源金炯九李焕铁
Owner 爱恩斯生物科技(昆山)有限公司
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