Hyaluronic acid microspheres capable of regulating and controlling filling bubbles and preparation method of hyaluronic acid microspheres
A technology of hyaluronic acid and hyaluronate, which is used in cosmetic filling materials, medical drug sustained release and targeted drug delivery, and can solve the problems of high hyaluronic acid price and increased production cost of hyaluronic acid microspheres. Achieve the effects of increasing productivity, reducing costs and saving raw materials
Active Publication Date: 2022-03-25
上海玮沐医疗科技有限公司
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Problems solved by technology
[0004]Although the hyaluronic acid microspheres obtained above have good biocompatibility and biodegradability, hyaluronic acid is expensive, and the hyaluronic acid microspheres are increased Therefore, it is necessary to provide a preparation method to reduce the cost while maintaining good compatibility and degradability
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[0029] Example
[0030] The embodiment provides a controllable bubble-filled hyaluronic acid microsphere and a preparation method thereof, wherein the microsphere includes a hyaluronic acid gel sphere and air bubbles inside the hyaluronic acid gel sphere. include:
[0031] Activation of hyaluronate: add 6.0g of hyaluronate into 44.0g, 2mol / L NaCl solution and mix, then add a mixed solution of 0.5751g of EDC and 0.3453g of NHS dissolved in 2ml of water in an ice-water bath, and adjust the pH value to 4-5, activate overnight at 4°C to obtain an activated hyaluronic acid solution;
[0032] Hyaluronic acid cross-linking: add 0.36g chitosan to 11.64g, 1wt% acetic acid aqueous solution to obtain an alkaline polysaccharide solution, mix the activated hyaluronic acid solution, alkaline polysaccharide solution, and air bubble regulator, as the water phase, add 600g oil phase (the oil phase is butyl acetate and cellulose acetate butyrate, wherein cellulose acetate butyrate accounts ...
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The invention relates to A61L, more specifically, the invention belongs to the field of medical drug sustained release and targeted drug delivery, also belongs to the field of cosmetic filling materials, and particularly relates to a hyaluronic acid microsphere capable of regulating and controlling filling bubbles and a preparation method thereof, and the microsphere comprises a hyaluronic acid gel ball and the bubbles located in the hyaluronic acid gel ball. Natural alkaline polysaccharide and sodium hyaluronate are coupled to prepare chemically cross-linked hydrogel, a regulator is added to regulate and control the number of bubbles in microspheres, finally, the microspheres obtained through oil-water suspension polymerization are filled with the bubbles, the use amount of hyaluronic acid can be reduced, meanwhile, the microspheres with the same particle size can be obtained, the cost is reduced, and the yield is increased. The method has the advantages that the reaction conditions are simple, the cross-linking agent is made of natural polymer materials, the gel is high in thermal stability and good in biocompatibility, raw materials are saved and the like, and the method can be applied to the fields of cosmetics, tissue filling and repairing, biological scaffolds, ophthalmology, drug sustained release, targeted drug delivery and the like.
Description
technical field [0001] The present invention relates to A61L. More specifically, the present invention belongs to the field of sustained-release and targeted drug delivery of medical drugs, and also belongs to the field of cosmetic filling materials. Specifically, it relates to hyaluronic acid microspheres that can be regulated and filled with air bubbles and a preparation method thereof. Background technique [0002] As an indispensable hyaluronic acid sodium salt in human tissues, hyaluronic acid has a high degree of water retention and plays an important role in the maintenance of the overall structure of the tissue and the transportation between cells. It was originally used clinically for Treatment of osteoarthritis and cataract surgery. Among them, hyaluronic acid is a natural polymer material that exists in animals, plants or the human body. It has good biocompatibility, almost all of which are degradable, and the low molecular products of degradation are non-toxic an...
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IPC IPC(8): A61L27/20A61L27/50A61L27/52A61L27/58A61L31/04A61L31/14A61K8/73A61Q19/00A61K9/06A61K47/36C08J3/24C08L5/08
CPCA61L27/20A61L27/50A61L27/52A61L27/58A61L31/042A61L31/14A61L31/145A61L31/148A61K8/735A61K8/736A61Q19/00A61K9/06A61K47/36C08J3/246C08J2305/08C08J2405/08A61L2300/412C08L5/08
Inventor 陈松解荡
Owner 上海玮沐医疗科技有限公司