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Thread bolt for manufacturing animal ischemic cerebral apoplexy model

A technology of ischemic stroke and model, which is applied in veterinary instruments, veterinary surgery, medical science, etc., can solve the problems of difficult modeling, low success rate, increased animal bleeding, etc., and improve the efficiency of modeling and success rate, improve the success rate of modeling, and the effect of simple structure

Pending Publication Date: 2022-04-01
BEIJING NEUROSURGICAL INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Secondly, in the process of modeling, it is best to control the insertion depth of the thread plug. When the insertion depth of the thread plug is insufficient, because the blood flow of the ACA cannot be completely blocked, it may lead to the realization of animals without obvious neurological deficits or symptoms. Light; when the insertion depth of the thread plug is too large, it may cause subarachnoid hemorrhage in experimental animals, which directly leads to increased bleeding or death of animals, and due to the differences in drug administration, growth cycle and individuals among model animals, even if Animals with the same body weight have different insertion depths when making models, which requires flexible control by the operator; in addition, because there are many bifurcations in the blood vessels in the brain, it is also necessary to pay attention to the depth of thread plugs during the advancement of the thread plugs. Propelling force to avoid puncturing blood vessels requires high operator experience
The above factors directly lead to the low success rate and difficulty of modeling in experimental animals.

Method used

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  • Thread bolt for manufacturing animal ischemic cerebral apoplexy model
  • Thread bolt for manufacturing animal ischemic cerebral apoplexy model
  • Thread bolt for manufacturing animal ischemic cerebral apoplexy model

Examples

Experimental program
Comparison scheme
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no. 1 example

[0036] Such as Figure 1-2 As shown, the following is the first embodiment of the present invention, specifically as follows:

[0037] A thread plug for making animal ischemic stroke models, comprising a head end 20 and a tail end 10, wherein the head end 20 and the tail end 10 have identical structures. Specifically, the ends of the head end 20 and the tail end 10 that are far away from each other are both set in a smooth round blunt shape, and the head end 20 and the tail end 10 both include a raw material line 21 located in the inner layer, a material line located in the raw material The outer coating layer 22 and the paint layer 23 of the wire 21 .

[0038] In this embodiment, the raw material line 21 is nylon material, the coating layer 22 is silica gel, and the coating layer 23 is a polyvinylpyrrolidone hydrophilic coating. Equal and both are 0.1mm-6mm. More specifically, the diameter of the raw material wire 21 is 0.15mm, and the thickness of the polyvinylpyrrolidone...

no. 2 example

[0043] Such as image 3 As shown, the following is the second embodiment of the present invention, specifically as follows:

[0044] A thread plug for making an animal ischemic stroke model, comprising a head end 20 and a tail end 10, the structure and length of the head end 20 and the tail end 10 are different, and the head end 20 and the tail end 10 are There is also a flexible segment 30 between them. Specifically, the end of the head end 20 away from the tail end 10 is set in a smooth rounded blunt shape, the diameter of the head end 20 is less than or equal to the diameter of the tail end 10, and the head end 20 has a diameter smaller than or equal to the diameter of the tail end 10. The length of the end 20 is greater than the length of the tail end 10, the tail end 10 can be taken, and the front end can be used as an insertion section for blocking blood vessels.

[0045] In this embodiment, the head end 20 and the tail end 10 both include a raw material wire 21 located...

no. 3 example

[0051] Such as Figure 4 Shown, the following is the third embodiment of the present invention, specifically as follows:

[0052] A thread plug for making an animal ischemic stroke model, comprising a tail end 10, a flexible section 30, a secondary tail end 40 and a head end 20 arranged in sequence, the lengths of the tail end 10 and the secondary tail end 40 and The structures are all the same and can be grasped. The head end 20 can be inserted into the blood vessel to block the blood vessel so as to establish a cerebral ischemia model.

[0053] In this embodiment, the ends of the head end 20 away from the tail end 10 are all set in a smooth blunt shape, and the diameter of the head end 20 is equal to the diameters of the tail end 10 and the secondary tail end 40 . Specifically, the head end 20 includes a raw material wire 21 located in the inner layer, a cladding layer 22 and a coating layer 23 located outside the raw material wire 21, wherein the raw material wire 21 is ma...

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Abstract

The invention relates to the technical field of animal experiment modeling instruments, in particular to a suture for manufacturing an animal ischemic cerebral apoplexy model, which comprises a head end and a tail end, the diameter of the head end is smaller than or equal to that of the tail end, and at least one flexible section is arranged between the head end and the tail end. And the diameter of the flexible section is smaller than that of the head end. The suture for manufacturing the animal ischemic cerebral apoplexy model is simple in structure and low in manufacturing cost, can effectively overcome the defects caused by insufficient experience of an operator, and greatly improves the success rate of modeling.

Description

technical field [0001] The invention relates to the technical field of animal experiment modeling instruments, in particular to a thread embolus for making animal ischemic stroke models. Background technique [0002] A stroke occurs due to interruption of blood supply to an area of ​​the brain and can result in death or permanent neurological deficits. Neurological deficits that occur after a stroke include balance problems, hemiplegia, loss of sensory and vibratory sensations, numbness, decreased reflexes, Ptosis, visual field defects, aphasia and apraxia, etc. According to the pathological basis, stroke can be divided into ischemic stroke or hemorrhagic stroke, and ischemic stroke accounts for a relatively high proportion of stroke. After ischemia, neuronal cells cannot maintain normal transmembrane ion gradient and balance, which leads to a series of cell death processes, including apoptosis, excitotoxicity, oxidative stress and inflammation, etc. These pathophysiologica...

Claims

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Application Information

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IPC IPC(8): A61D1/00A61B17/12
Inventor 刘爱华张宝瑞莫大鹏霍晓川宋光荣缪中荣吴中学刘浪夏赛德柴旭斌
Owner BEIJING NEUROSURGICAL INST