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Thermo-sensitive embolism microsphere and preparation method thereof

A technology for embolizing microspheres and temperature sensitivity, applied in the field of medical devices, can solve the problems of poor suspension, low shrinkage rate, inability to embolize microspheres, etc.

Active Publication Date: 2022-04-05
科睿驰(深圳)医疗科技发展有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this core-shell microsphere can only be used if it is designed to be nanoscale. Once the core-shell microsphere is designed into a micron-scale with a larger particle size, its shrinkage rate is very low, and its suspension is very poor, so it cannot be used as an embolism. Microsphere use

Method used

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  • Thermo-sensitive embolism microsphere and preparation method thereof
  • Thermo-sensitive embolism microsphere and preparation method thereof
  • Thermo-sensitive embolism microsphere and preparation method thereof

Examples

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preparation example Construction

[0043] The embodiment of the present application also provides a method for preparing the above-mentioned temperature-sensitive embolic microspheres, which includes the following steps:

[0044] (1) Prepare the oil phase system: add the oil-soluble dispersant to the oil phase solvent, stir and dissolve to form a uniform oil phase system.

[0045] Wherein, the oil-soluble dispersant is at least one of Span 20, Span 80, Tween 20, Tween 80, cellulose acetate, and cellulose acetate butyrate; the oil-soluble solvent is liquid paraffin, n-heptane, acetic acid At least one of ethyl ester and butyl acetate; the mass percentage of the oil-soluble dispersant in the oil phase is 1%-2%.

[0046] (2) Prepare the water phase system: first prepare the water-soluble polymer into a certain concentration of polymer aqueous solution; then dissolve the water-soluble monomer, cross-linking agent, and initiator in water to prepare a monomer aqueous solution; The aqueous solution and the monomer aq...

Embodiment 1

[0058] This example provides a series of temperature-sensitive embolic microspheres, which are prepared by reverse suspension polymerization. The specific preparation method is as follows:

[0059] (1) Preparation of oil phase system

[0060] Add 300mL of liquid paraffin into the four-necked bottle, measure 5mL of Span 80 into the four-necked bottle, stir and mix the liquid paraffin and Span 80 until a uniform oil phase system is formed.

[0061] (2) Preparation of water phase

[0062] First, prepare a 12% polyvinyl alcohol aqueous solution (containing about 12 g of polyvinyl alcohol) with a mass fraction of 12% under the condition of heating in a constant temperature water bath at 80°C; another 2 g of 2-acrylamido-2-methylpropanesulfonic acid (AMPS) was weighed , 3g of N-isopropylacrylamide (NIPAM), 0.02g of N,N-methylenebisacrylamide, 0.35mL of aminoacetaldehyde dimethyl acetal, 0.02g of ammonium persulfate, 0.04mL Tetramethylethylenediamine was added into 5mL of deionized...

Embodiment 2-5

[0077] This example provides a thermosensitive embolic microsphere respectively, the difference between the preparation method and Example 1 is that the mass percentage of NIPAM to the total amount of monomers is different, that is, the amount of NIPAM is different.

[0078] Test the particle size distribution width of the 300-500 μm embolic microspheres obtained by sieving in Example 2-5 at 37°C, and the particle size shrinkage relative to 25°C, the results are as follows Figure 4 and shown in Table 2.

[0079] Table 2 Effect of NIPAM dosage on particle size distribution of 300-500 μm embolic microspheres

[0080] group Example 2 Example 3 Example 4 Example 5 Dosage of NIPAM 5％ 10％ 20％ 30％ Particle size distribution width W / μm 140 95 67 36 Average particle size shrinkage rate R / % 14.2 37.3 51.9 64.3

[0081] NIPAM dosage: the mass percentage of NIPAM in the total amount of monomers.

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Abstract

The embodiment of the invention provides a temperature-sensitive embolism microsphere and a preparation method thereof, and relates to the field of medical instruments. The thermo-sensitive embolism microsphere is mainly of a three-dimensional network structure formed by mutual crossing and winding of a cross-linked structure formed by cross-linking polymerization of a water-soluble high-molecular polymer and a first cross-linking agent and a cross-linked structure formed by cross-linking polymerization of a water-soluble monomer, a thermo-sensitive molecule and a second cross-linking agent. The preparation method of the thermo-sensitive embolism microspheres comprises the following steps: adding a water-phase system which is mainly prepared from a water-soluble high-molecular polymer, a water-soluble monomer, thermo-sensitive molecules and a cross-linking agent into an oil-phase system to form a water-in-oil reversed-phase suspension polymerization system; and carrying out a cross-linking polymerization reaction on the reversed-phase suspension polymerization system. The embolism microsphere disclosed by the embodiment of the invention is easy to produce and prepare and has temperature sensitivity; the particle size of the embolism microspheres in a certain specification range shrinks when the temperature rises, and the particle size distribution is narrowed, so that the embolism microspheres can be accurately matched with the blood vessel size of a patient.

Description

technical field [0001] The present application relates to the field of medical devices, in particular to a temperature-sensitive embolic microsphere and a preparation method thereof. Background technique [0002] Most of the existing embolic microspheres are obtained by suspension polymerization, and the particle size distribution of the prepared microspheres ranges from tens of microns to thousands of microns, and then products of different specifications are obtained through subsequent screening. However, limited by the screening device and screening process, the particle size distribution of microspheres of various specifications usually obtained is still relatively wide, such as 100-300 μm, 300-500 μm, etc. From the perspective of clinical application, the higher the matching between the particle size of the selected microspheres and the size of the embolized blood vessel, the better the embolization effect will be obtained. Therefore, the width of the particle size dist...

Claims

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Application Information

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IPC IPC(8): A61L24/06A61L24/00C08F220/54C08F220/58C08F222/38C08F220/56C08F2/32
Inventor 姚丽娟孙蓬孙宏涛车海波
Owner 科睿驰(深圳)医疗科技发展有限公司
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