Application of injectable magnetic nanoparticles in preparation of drugs for treating endocrine diseases

Abstract

The invention discloses an application of injectable magnetic nanoparticles in preparation of drugs for treating endocrine diseases. Belongs to the field of endocrine prevention and treatment. Endocrine is regulated based on hormone, and nerve magnetic stimulation is enhanced by using a magnetic nano material, so that the effect of regulating endocrine is realized; the invention discloses a fixed-point drug delivery method and a magnetic stimulation treatment device at the same time. Besides, the magnetic nano material is a nano material which is formed by taking gamma-Fe2O3 as a core and PSC as a shell, and the material is superparamagnetic, high in stability and good in biocompatibility; the magnetic stimulation treatment device is a dynamic magnetic field which is composed of a permanent magnet and a rotary motor and is used for magnetic stimulation treatment. The method can be applied to magnetic stimulation of other brain regions or nerve nuclei at the same time, and the method is simple and easy to implement and has certain medical research prospects.

Description

technical field [0001] The invention belongs to the field of magnetic nanomaterials, and relates to a new method for regulating endocrine diseases by nerve magnetic stimulation, in particular, it relates to a method for administering the above-mentioned injectable magnetic nanomaterials for treating endocrine diseases and the above-mentioned magnetic nanomaterials. Methods of application of magnetic field action. Background technique [0002] Repetitive transcranial magnetic stimulation (rTMS) has been widely used in the treatment of nervous system diseases. It can generate induced currents in the brain through dynamic magnetic fields, change the potential difference of cell membranes, remove polarized cell membranes, activate excitable nerve cells and regulate neurons. Function; according to Faraday's law, the magnetic field pulse will induce an electric field in the brain, and induce an induced current in the brain tissue; when the induced current exceeds the threshold val...

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Problems solved by technology

[0002] Repetitive transcranial magnetic stimulation (rTMS) has been widely used in the treatment of nervous system diseases. It can generate induced currents in the brain through dynamic magnetic fields, change the potential difference of cell membranes, remove polarized cell membranes, activate excitable nerve cells and regulate neurons. Function; according to Faraday's law, the magnetic field pulse will induce an electric field in the brain, and induce an induced current in the brain tissue; when the induced current exceeds the threshold value of nerve block excitation, the magnetic stimulation can stimulate the corresponding brain tissue like electrical stimulation, And cause neural activity; however, rTMS has the disadvantages of poor penetration depth, low focusing accuracy, difficult positioning and high energy consumption, so that it can only act on the human cortical brain area and cannot reach the deep nuclei; based on this, Using electromagnetic stimulation technology based on magnetic nanoparticles - Magnetic Nanoparticle Combined Magnetic Stimulation (c-MSS) to achieve precise magnetic stimulation of deep nuclei; Superparamagnetic Iron Oxide Nanoparticles (SPIO) are physically and chemically stable and biocompatible The characteristics of safety and environmental safety; through stereotaxic injection of iron oxide nanoparticles to deep nuclei, such as paraventricular nucleus, hippocampus, etc., plus a neutral magnetic field, to achieve precise stimulation of specific parts, so as to regulate the neuroendocrine system

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