The invention discloses a compound plant-caused transdermal patch for treating prostatic hyperplasia and a preparation method thereof. The transdermal patch comprises the main components of, by weight, 20 parts of African pygeum extract, 20 parts of serenoa serrulata extract, 12 parts of pumpkin seed oil, 11 parts of tribulus terrestris extract, 12 parts of eurycoma longifolia extract, 12 parts of boschniakia rossica extract, 12 parts of cherokee rose fruit extract and 1 part of polyvinylpyrrolidone. A preparation method includes the concrete steps of dosing, coating, covering and punching. In combination with the effects that the kidneys are invigorated, Yang is strengthened, qi is benefited, blood circulation is promoted, essence is secured, urination is reduced, and sterilization, inflammation prevention, swelling elimination, hormone regulation and tissue proliferation restraining are carried out, the transdermal patch comprehensively improves internal and external physiological states of the prostate at the physiological level of molecules, eliminates inflammation and proliferation, and recovers the prostate body; direct transdermal patching on the focus is adopted, the internal illness is treated by external treatment, in this way, medicine penetration and medicine absorption are effectively achieved for the prostate, and the pathological conditions of the prostate are directly improved for a patient.