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Preparation method and application of artificial melanin nano material

A nanomaterial, artificial technology, applied in the field of artificial melanin, can solve the problems of large product difference, long production cycle, unstable process, etc., and achieve the effects of low cytotoxicity, good biocompatibility and good repeatability

Active Publication Date: 2022-04-12
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, such biological methods generally have problems such as long production cycle, unstable process, large product diversity, and low yield.

Method used

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  • Preparation method and application of artificial melanin nano material
  • Preparation method and application of artificial melanin nano material
  • Preparation method and application of artificial melanin nano material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The concrete steps of present embodiment preparation artificial pyomelanoin nanometer material are as follows:

[0053] (1) With ethanol-containing deionized water as a solvent (wherein ethanol weight accounts for 25%), a homogentisic acid solution with a concentration of 3 mg / mL is prepared, and the homogentisic acid solution is subjected to ultrasonic treatment for 5 minutes, so that the high Gentisic acid is evenly dispersed. After that, it was stirred at room temperature for 5 minutes to obtain a transparent and colorless homogentisic acid solution, which was kept stirring at room temperature and set aside.

[0054] (2) Using deionized water as a solvent, prepare a sodium periodate solution with a concentration of 214mg / mL, keep stirring in a water bath at 50°C, and set aside.

[0055] (3) in the pergentisic acid solution, sodium periodate solution is added dropwise. During the dropping process, it can be observed that the transparent and colorless solution gradual...

Embodiment 2

[0061] In this embodiment, a desktop scanning electron microscope was used to observe the microscopic morphology of the sample PHA.

[0062] The sample PHA was prepared as a sample PHA solution with a concentration of 1 mg / mL, which was spin-coated on the surface of a smooth mica sheet, followed by drying and gold-spraying treatment for observation. The obtained scanning electron microscope pictures are shown in figure 1 . From figure 1 It can be seen that the sample PHA is a nanoparticle with good shape and uniform particle size, and the statistical particle size range is 147nm-165nm.

Embodiment 3

[0064] In this example, statistics on the particle size and yield of the samples in Table 1 were carried out, and the particle size of the sample was measured from the scanning electron microscope photos of the sample using Image J software, and the average value was calculated.

[0065] The mass ratios of homogentisic acid and sodium periodate in samples PHA and 4-7 were both 6:7, and the reaction times were 24h, 8h, 12h, 16h, and 48h, respectively. Test and count the particle size and yield of samples PHA, 4-7, see figure 2 . From figure 2 It can be seen that with the prolongation of the reaction time, the particle size and yield of the sample both increased first and then tended to be stable, and the particle size and yield of the sample reached a stable state at 24 h.

[0066] The reaction time of sample PHA and samples 2-3 were both 24 hours, and the mass ratios of homogentisic acid to sodium periodate were 6:7, 6:11.5, and 6:15.5, respectively. Test and count the pa...

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Abstract

The invention discloses a preparation method and application of an artificial melanin nano-material. The method comprises the following steps: preparing a sodium periodate solution and a homogentisic acid solution, dropwise adding the sodium periodate solution into the homogentisic acid solution, reacting for 8-24 hours, and sequentially carrying out centrifugal treatment and deionized water washing on the reaction solution to obtain the artificial melanin nano-material. Wherein the dosage of the sodium periodate is 6 parts by weight, and the dosage of the homogentisic acid is 2-20 parts by weight. According to the method, the artificial melanin nano material is synthesized by adopting a chemical method for the first time, and compared with a biosynthesis method, the method disclosed by the invention is more efficient, adjustable and controllable, good in repeatability and suitable for industrial production. The prepared artificial melanin nano material has physical and chemical properties similar to those of natural melanin, including regular particle morphology, good antioxidant ability, good ultraviolet light absorption ability, good free radical scavenging ability and the like, and can be used as an antioxidant material, a light absorption material, a photo-thermal conversion material and a photo-thermal sterilization material.

Description

technical field [0001] The invention belongs to the technical field of artificial melanin, and in particular relates to a preparation method and application of an artificial pyomelanin nanomaterial. Background technique [0002] Melanin widely exists in plants, animals, even bacteria and fungi in nature, mainly including eumelanin, pheomelanin, neuromelanin, isomelanin and pyomelanin. The lack of melanin will have a great negative impact on human daily life and health. However, there are many difficulties in obtaining melanin from nature and further applying it. [0003] Starting from the small molecular precursors of biomass, artificial biomacromolecules that are similar in structure, properties, and functions to natural biomacromolecules can be constructed through rational design of macromolecular physics and chemical methods. For example, starting from small molecules of dopamine precursors, artificial eumelanin materials can be constructed through automatic oxidation u...

Claims

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Application Information

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IPC IPC(8): C08G63/06C08G63/78A61K41/00A61P31/04B82Y5/00B82Y40/00
Inventor 李乙文王天佑李昊天顾志鹏
Owner SICHUAN UNIV
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