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Multi-mode FePt-coated Fe3O4 nano contrast agent as well as preparation method and application thereof

A nano-contrast agent, multi-modal technology, applied in the field of biological and medical nanomaterials, can solve problems such as low sensitivity

Active Publication Date: 2022-04-15
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitation of low inherent sensitivity, it is usually necessary to work under a strong magnetic field higher than 1T

Method used

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  • Multi-mode FePt-coated Fe3O4 nano contrast agent as well as preparation method and application thereof
  • Multi-mode FePt-coated Fe3O4 nano contrast agent as well as preparation method and application thereof
  • Multi-mode FePt-coated Fe3O4 nano contrast agent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1. Synthesis of FePt@Fe 3 O 4 Multimodal Nanocontrast Agent (c4.5s12.5)

[0049] In a 50ml three-necked flask, add 0.5mmol of platinum acetylacetonate, 3mmol of iron acetylacetonate, 5mmol of oleic acid, 5mmol of oleylamine, 1.8mmol of 1,2-hexadecanediol and 10ml (35mmol) of hexadecene, at 80°C Stir and evacuate for 60 minutes, followed by high temperature reflux at 300°C for 30 minutes under nitrogen. After the reaction was completed, it was cooled to room temperature, and ethanol was added at 6000 r / min for centrifugation for 10 minutes. After precipitation, cyclohexane was added for centrifugation to collect the supernatant, and the centrifugation operation was repeated twice. The product was dispersed in cyclohexane and placed in a 4°C refrigerator. in standby. Add 40ml of acetone to the above 2ml oil phase sample (mass concentration of about 18mg / ml) and centrifuge at 6000r / min for 10 minutes to get the precipitate (about 36mg), then add 4ml of tetrahydr...

Embodiment 2

[0051] Example 2. Synthesis of FePt@Fe 3 O 4 Multimodal Nanocontrast Agent (c3.3s8.5)

[0052] In a 50ml three-necked flask, add 0.5mmol of platinum acetylacetonate, 2mmol of iron acetylacetonate, 5mmol of oleic acid, 5mmol of oleylamine, 1.5mmol of 1,2-hexadecanediol and 20ml (62.5mmol) of octadecene, at 80°C Vacuum with stirring for 30 minutes, followed by high temperature reflux at 300°C for 30 minutes under nitrogen. After the reaction was completed, it was cooled to room temperature, and ethanol was added at 6000 r / min for centrifugation for 10 minutes. After precipitation, cyclohexane was added for centrifugation to collect the supernatant, and the centrifugation operation was repeated twice. The product was dispersed in cyclohexane and placed in a 4°C refrigerator. in standby. Add 40ml of acetone to the above-mentioned 2ml oil phase sample (mass concentration of about 12mg / ml) and centrifuge at 6000r / min for 10 minutes to get the precipitate, then add 4ml of tetrahyd...

Embodiment 3

[0054] Example 3. Synthesis of FePt@Fe 3 O 4 Multimodal Nanocontrast Agent (c3.3s12.5)

[0055]In a 50ml three-necked flask, add 0.3mmol of platinum acetylacetonate, 2mmol of iron acetylacetonate, 5mmol of oleic acid, 5mmol of oleylamine, 0.9mmol of 1,2-hexadecanediol and 20ml (62.5mmol) of octadecene, at 80°C Vacuum with stirring for 30 minutes, followed by high temperature reflux at 300°C for 45 minutes under nitrogen. After the reaction was completed, it was cooled to room temperature, and ethanol was added at 6000 r / min for centrifugation for 10 minutes. After precipitation, cyclohexane was added for centrifugation to collect the supernatant, and the centrifugation operation was repeated twice. The product was dispersed in cyclohexane and placed in a 4°C refrigerator. in standby. Add 40ml of acetone to the above-mentioned 2ml oil phase sample (mass concentration of about 10mg / ml) and centrifuge at 6000r / min for 10 minutes to get the precipitate, then add 4ml of tetrahyd...

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Abstract

The invention discloses a multi-mode FePt-coated Fe3O4 nano contrast agent as well as a preparation method and an application of the multi-mode FePt-coated Fe3O4 nano contrast agent. The multi-mode FePt-coated Fe3O4 nano contrast agent disclosed by the invention is a FePt-coated Fe3O4 inorganic nano particle of which the surface is modified with polyethylene glycol; the FePt-coated Fe3O4 inorganic nanoparticles are nanocrystals with FePt alloy as a core and Fe3O4 as a shell, the overall size of the FePt-coated Fe3O4 inorganic nanoparticles is 5-20 nm but not 20 nm, and the size of a core region is 1-10 nm. The FePt-coated Fe3O4 nano contrast agent provided by the invention can provide a positive T1-T2 contrast ratio in an MRI (Magnetic Resonance Imaging) strong magnetic field, provides an obvious residual magnetism signal in ultra-low field magnetic imaging, realizes brand new T1-T2-ULF (Ultra-low Frequency) multi-modal imaging, can be applied to the fields of medical imaging, targeted therapy, visual tracking and the like, and has remarkable practical significance and practical value.

Description

technical field [0001] The present invention relates to a kind of FePt@Fe 3 O 4 The invention discloses a manufacturing method and application of a multimodal nano-contrast agent based on magnetic resonance imaging / ultra-low-field magnetic imaging, and belongs to the technical field of biological and medical nanomaterials. Background technique [0002] Magnetic resonance imaging (MRI) has the advantages of high soft tissue contrast, high spatial resolution, no ionizing radiation, and wide clinical applicability. It is a valuable non-invasive imaging method. However, due to the limitation of low intrinsic sensitivity, it usually needs to work under a strong magnetic field higher than 1T. The nanocontrast agent shortens the longitudinal (T1) or transverse (T2) relaxation time of nearby water molecules due to the interaction with surrounding water protons, which can further improve the sensitivity of MRI and obtain information-rich images. Among them, T1-weighted imaging can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K49/18B82Y5/00B82Y30/00B82Y40/00
CPCY02A90/30
Inventor 姚立肖含章赵丹柴亚红
Owner INST OF CHEM CHINESE ACAD OF SCI
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