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Multifunctional hemostatic material and preparation method thereof

A hemostatic material and multifunctional technology, applied in the field of medical materials, can solve problems such as bleeding wounds that cannot be used

Active Publication Date: 2022-04-15
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostasis of chitosan has certain limitations in application, and it can only be used for small areas of hemostasis, and cannot be used for large areas of bleeding wounds

Method used

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  • Multifunctional hemostatic material and preparation method thereof
  • Multifunctional hemostatic material and preparation method thereof
  • Multifunctional hemostatic material and preparation method thereof

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preparation example Construction

[0025] A method for preparing a multifunctional hemostatic material provided by an embodiment of the present invention comprises the following steps:

[0026] S1. Preparation of Modified Pluronic F127

[0027] Please refer to figure 1 In (a), the modification of Pluronic F127 is to carry out the aldylation reaction of Pluronic F127. The general reaction steps include: after mixing and reacting F127, organic solvent, p-formylbenzoic acid, 4-dimethylaminopyridine and dicyclohexylcarbodiimide, extract with saturated salt solution, and then precipitate activated F127 with organic solvent ; After the activated F127 is mixed with cysteamine and an organic solvent, it is separated and dried.

[0028] The specific reaction steps can be as follows: Weigh 20g of PEO-PPO-PE0 molecules, 1g of p-formylbenzoic acid and 50mg of 4-dimethylaminopyridine in a three-necked flask, and then add 150mL of dichloromethane to the above reaction flask, Then 5.48 g of dicyclohexylcarbodiimide were ad...

Embodiment 1

[0054] This embodiment provides a method for preparing a multifunctional hemostatic material. The multifunctional hemostatic material is composed of chitosan solution, formylated F127, drug-loaded short fibers coated with polydopamine, and polydopamine particles, which includes the following steps :

[0055] 1. Preparation of Components in the Gel Precursor Solution

[0056] (1) Prepare chitosan solution: get 0.33g chitosan (Mn=100-200kDa, degree of deacetylation>95%) and dissolve it in 10mL acetic acid aqueous solution (concentration is 0.1M) to obtain 0.033g / mL Chitosan solution.

[0057] (2) Preparation of aldylated F127 solution: First, prepare aldylated F127, the specific operation steps are to weigh 20g of PEO-PPO-PE0 molecules, 1g of p-formylbenzoic acid and 50mg of 4-dimethylaminopyridine in three necks flask, and then add 150 mL of dichloromethane to the reaction flask, and then add 5.48 g of dicyclohexylcarbodiimide. Under nitrogen conditions, stir and react at ro...

Embodiment 2

[0067] This embodiment provides a method for preparing a multifunctional hemostatic material. The multifunctional hemostatic material is composed of quaternized chitosan solution, formylated F127, drug-loaded short fibers coated with polydopamine, and tranexamic acid drug. It includes the following steps:

[0068] 1. Preparation of Components in the Gel Precursor Solution

[0069] (1) Preparation of quaternized chitosan solution: 1g chitosan (Mn=100-200kDa, degree of deacetylation>95%) is dissolved in 10mL acetic acid aqueous solution (concentration is 0.1M) to obtain 0.1g / mL chitosan solution.

[0070] (2) Preparation of aldylated F127 solution: First, prepare aldylated F127, the specific operation steps are to weigh 20g of PEO-PPO-PE0 molecules, 1g of p-formylbenzoic acid and 50mg of 4-dimethylaminopyridine in three necks flask, and then add 150 mL of dichloromethane to the reaction flask, and then add 5.48 g of dicyclohexylcarbodiimide. Under nitrogen conditions, stir an...

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Abstract

The invention discloses a multifunctional hemostatic material and a preparation method thereof, and relates to the technical field of medical materials. The preparation method of the multifunctional hemostatic material comprises the following steps: (1) preparing modified pluronic F127: carrying out hydroformylation reaction on F127; (2) preparation of modified drug-loaded nanofibers: mixing a degradable polymer, an anti-inflammatory drug and an organic solvent to form a to-be-spun solution, and spinning to obtain the drug-loaded nanofibers; depositing polydopamine on the medicine carrying nano fiber; and (3) preparation of a procoagulant material: dissolving and dispersing chitosan or a chitosan derivative, the modified pluronic F127, the modified drug-loaded nanofiber and a hemostatic or healing-promoting drug in water, mixing, and reacting. The prepared hemostatic material has moisture retention, injectability and biocompatibility, and has the functions of resisting bacteria, diminishing inflammation and promoting wound healing.

Description

technical field [0001] The invention relates to the technical field of medical materials, and in particular to a multifunctional hemostatic material and a preparation method thereof. Background technique [0002] At present, there are various kinds of medical hemostatic materials. The hemostatic materials that have been approved for clinical use can be roughly divided into: (1) Coagulation factor concentrates, which mainly use the physical and chemical properties of the materials themselves to absorb the water in the blood and promote the healing of the wound site. (2) Mucoadhesives, the hemostatic material exhibits strong tissue adhesion and can physically seal bleeding wounds without participating in the coagulation cascade reaction. (3) Coagulation-promoting supplements, which work by providing high concentrations of coagulation factors in the bleeding wound and directly activating the coagulation cascade. They are mainly pro-coagulant materials that can be injected or co...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/04A61L24/00A61K41/00A61P31/04
CPCA61L24/08A61L24/046A61L24/001A61L24/0015A61L24/0031A61K41/0052A61P31/04A61L2400/04A61L2300/404A61L2300/41A61L2300/412A61L2400/06A61L2400/12A61L2300/418A61L2300/602A61L2300/402A61L2300/216A61L2300/214C08L71/02C08L79/02C08L5/08C08L67/04
Inventor 杨光曹敏林莉敏许豪良杨婷何洋蒋正鑫
Owner SOUTHWEST JIAOTONG UNIV
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