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Dressing containing hirudin and preparation method thereof

A technology containing hirudin and hirudin, which is applied to medical preparations containing active ingredients, medical preparations with non-active ingredients, medical raw materials derived from leeches/worms, etc., which can solve poor therapeutic effects and inconvenient use, etc. problem, achieve the effect of improving adhesion, avoiding shedding, and accelerating repair

Pending Publication Date: 2022-04-22
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides a hirudin-containing dressing and a preparation method thereof, which can effectively solve the problems of poor therapeutic effect and inconvenient use of existing drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A dressing containing hirudin, comprising the following components in parts by weight: 1 part of hirudin, 1 part of astragalus extract, 1 part of angelica extract, 1 part of Chuanxiong extract, 1 part of asarum extract, and earthworm extract 1 part, 1 part of Clematis extract, 1 part of borneol, 3 parts of natural polysaccharide and 3 parts of polyvinyl alcohol.

[0023] The preparation method of above-mentioned dressing containing hirudin, comprises the following steps:

[0024] (1) dissolving polyvinyl alcohol to make a mass concentration of 8% polyvinyl alcohol aqueous solution, then adopting electrospinning to make spinning with a diameter of 10 μm, and then making the spinning into a porous base material with a thickness of 1 mm, Then dry it at 60°C;

[0025] (2) Add water to chitosan, stir and heat up to 70°C to dissolve completely, and make a gel with a mass ratio of 5% of chitosan, then add hirudin, astragalus extract, angelica extract, chuanxiong extract, Asa...

Embodiment 2

[0028] A hirudin-containing dressing, comprising the following components in parts by weight: 1 part of hirudin, 5 parts of astragalus extract, 5 parts of angelica extract, 1 part of Chuanxiong extract, 4 parts of asarum extract, and earthworm extract 3 parts, 5 parts of Clematis extract, 3 parts of borneol, 8 parts of natural polysaccharide and 10 parts of polyvinyl alcohol.

[0029] The preparation method of above-mentioned dressing containing hirudin, comprises the following steps:

[0030] (1) dissolving polyvinyl alcohol to make a mass concentration of 8% polyvinyl alcohol aqueous solution, then adopting electrospinning to make a spinning with a diameter of 5 μm, and then making the spinning into a porous base material with a thickness of 3 mm, Then dry it at 60°C;

[0031] (2) Add water to the starch, stir and heat up to 90°C until it dissolves completely, and make a gel with a mass ratio of 10% of the starch, and then add hirudin, astragalus extract, angelica extract, ...

Embodiment 3

[0034] A hirudin-containing dressing, comprising the following components in parts by weight: 2 parts of hirudin, 3 parts of astragalus extract, 2 parts of angelica extract, 2 parts of Chuanxiong extract, 3 parts of asarum extract, and earthworm extract 3 parts, 2 parts of Clematis extract, 1 part of borneol, 4 parts of natural polysaccharide and 8 parts of polyvinyl alcohol.

[0035] The preparation method of above-mentioned dressing containing hirudin, comprises the following steps:

[0036] (1) dissolving polyvinyl alcohol to make a mass concentration of 10% polyvinyl alcohol aqueous solution, then adopting electrospinning to make a spinning with a diameter of 8 μm, and then making the spinning into a porous base material with a thickness of 2 mm, Then dry it at 60°C;

[0037] (2) Add water to the cellulose, stir and heat up to 90°C to dissolve completely, and make a gel with a mass ratio of 8% of the cellulose, then add hirudin, astragalus extract, angelica extract, and c...

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Abstract

The invention discloses a dressing containing hirudin and a preparation method thereof. The dressing comprises the following components in parts by weight: 1-5 parts of hirudin, 1-5 parts of an astragalus extract, 1-5 parts of an angelica sinensis extract, 1-5 parts of a ligusticum wallichii extract, 1-5 parts of an asarum extract and 1-5 parts of an earthworm extract. 1-5 parts of radix clematidis extract, 1-3 parts of borneol, 3-8 parts of natural polysaccharide and 3-10 parts of polyvinyl alcohol. The dressing can effectively solve the problems that an existing medicine is poor in treatment effect and inconvenient to use.

Description

technical field [0001] The invention relates to the technical field of dressings, in particular to a hirudin-containing dressing and a preparation method thereof. Background technique [0002] Trauma injuries in daily life often cause swelling, bruising, dislocation and even fractures in the affected area, causing unbearable pain in the affected area and greatly affecting the life of the patient. The medicine for treating bruises on the market is of a great variety at present, and oral Chinese medicine, external spray, plaster, gel etc. are arranged, but, the curative effect of existing medicine for bruises is uneven. Moreover, the time for the existing external spray to act on the affected area is relatively short, and the active ingredients have limited effects; the existing plasters are generally made of drug powder plus auxiliary materials, and the active ingredients therein have limited exudation, resulting in a general therapeutic effect; After some gel medicines are ...

Claims

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Application Information

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IPC IPC(8): A61K38/58A61K9/70A61K47/36A61K47/32A61L15/24A61L15/28A61L15/32A61L15/42A61L15/44A61L15/46A61P17/02A61P29/00A61K31/045A61K35/62
CPCA61K38/58A61K36/481A61K36/232A61K36/236A61K36/268A61K35/62A61K36/716A61K31/045A61K9/7023A61K47/36A61K47/32A61P17/02A61P29/00A61L15/28A61L15/42A61L15/44A61L15/46A61L15/24A61L15/32A61L2300/252A61L2300/30A61L2300/412A61L2300/418A61L2300/402A61K2300/00
Inventor 石萍鲁增辉游华建邢康康张德利卫秋阳邓小书王嘉陈仕江谭发银
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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